Vaccination of goats with DNA vaccines encoding H11 and IL-2 induces partial protection against Haemonchus contortus infection

Veterinary Journal

Volumn 191, Issue 1, 2012, Pages 94-100

  Zhao, GuangWei ^a,b   Yan, RuoFeng ^a   Muleke, Charles I ^a   Sun, YanMing ^a   Xu, LiXin ^a   Li, XiangRui ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

^b SOUTHWEST UNIVERSITY   (China)

Author keywords

DNA vaccine; Goats; H11; Haemonchus contortus; Interleukin 2

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; HAEMONCHUS CONTORTUS H11 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 2; PARASITE ANTIGEN; RECOMBINANT DNA VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BLOOD CELL COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DNA IMMUNIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES ANALYSIS; FEMALE; GENETIC TRANSCRIPTION; GENOME SIZE; GOAT; HAEMONCHOSIS; HAEMONCHUS CONTORTUS; IMMUNOGLOBULIN PRODUCTION; MALE; MICROFILARIA (NEMATODE LARVA); MUSCLE; NONHUMAN; PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; RUMINANT STOMACH; WESTERN BLOTTING; WORM EGG;

ANIMALS; ANTIBODIES, HELMINTH; FEMALE; GOAT DISEASES; GOATS; HAEMONCHIASIS; HAEMONCHUS; INTERLEUKIN-2; MALE; TREATMENT OUTCOME; VACCINATION; VACCINES, DNA;

ANIMALIA; CAPRA HIRCUS; HAEMONCHUS CONTORTUS;

EID: 84855521541     PISSN: 10900233     EISSN: 15322971     Source Type: Journal    
DOI: 10.1016/j.tvjl.2010.12.023     Document Type: Article

References (35)

1. Alarcon J.B., Waine G.W., Manus D.P. DNA vaccines, technology and application as anti-parasite and anti-microbial agents. Advances in Parasitology 1999, 42:343-410.
2. Babai I., Barenholz Y., Zakay-Rones Z. A novel liposomal influenza vaccine (INFLUSOME-VAC) containing hemagglutinin-neuraminidase and IL-2 or GM-CSF induces protective anti-neuraminidase antibodies cross-reacting with a wide spectrum of influenza A viral strains. Vaccine 2001, 20:505-515.
3. Balic A., Bowles V.M., Meeusen E.N.T. Cellular profiles in the abomasal mucosa and lymph node during primary infection with Haemonchus contortus in sheep. Veterinary Immunology and Immunopathology 2000, 75:109-120.
4. Belosevic M., Finbloom D.S., Meltzer M.S., Nacy C.A. IL-2 - a cofactor for induction of activated macrophage resistance to infection. Journal of Immunology 1990, 145:831-839.
5. Chow Y.H., Huang W.L., Chi W.K., Chu Y.D., Tao M.H. Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. Journal of Virology 1997, 71:169-178.
6. Egan Michael A., Israel Zimra R. The use of cytokines and chemokines as genetic adjuvants for plasmid DNA vaccines. Clinical and Applied Immunology Reviews 2002, 2:255-287.
7. Karina Garcia-Martinez, Kalet Leon Modeling the role of IL-2 in the interplay between CD4+ helper and regulatory T cells: assessing general dynamical properties. Journal of Theoretical Biology 2010, 262:720-732.
8. Geldhof P., Claerebout E., Knox D., Vercauteren I., Looszova A., Vercruysse J. Vaccination of calves against O. ostertagi with cysteine proteinase enriched protein fractions. Parasite Immunology 2002, 24:263-270.
9. Harriet L., Robinson H.L. Nucleic acid vaccines: an overview. Vaccine 1997, 15:785-787.
10. Jackson F. Antihelmintic resistance - the state of play. British Veterinary Journal 1993, 149:123-138.
11. + T lymphocytes contribute to protective immunity induced in sheep and goats by Haemonchus contortus gut antigens. Parasite Immunology 1997, 19:435-445.
12. Kim J.J., Yang J.S., Manson K.H., Weiner D.B. Modulation of antigen-specific cellular immune responses to DNA vaccination in rhesus macaques through the use of IL-2, IFN-gamma, or IL-4 gene adjuvants. Vaccine 2001, 19:2496-2505.
13. Knox D.P., Smith W.D. Vaccination against gastrointestinal nematode parasites of ruminants using gut-expressed antigens. Veterinary Parasitology 2001, 12:21-32.
14. Lofthouse S.A., Andrews A.E., Elhay M.J., Bowles V.M., Meeusen E.N.T., Nash A.D. Cytokines as adjuvants for ruminant vaccines. International Journal for Parasitology 1996, 26:835-842.
15. Min W., Lillehoj H.S., Burnside J., Weining K.C., Staeheli P., Zhu J.J. Adjuvant effects of IL-1-β, IL-2, IL-8, IL-15, IFN-α, IFN-γ, TGF-β and lymphotactin on DNA vaccination against Eimeria acervulina. Vaccine 2001, 20:267-274.
16. Moore A.C., Kong W.P., Chakrabarti B.K., Nabel G.J. Effects of antigen and genetic adjuvants on immune responses to human immuno-deficiency virus DNA vaccines in mice. Journal of Virology 2002, 76:243-250.
17. Muleke C.I., Yan R.F., Sun Y.M., Zhao G.W., Xu L.X., Li X.R. Vaccination of goats against Haemonchus contortus with a recombinant cysteine protease. Small Ruminant Research 2007, 73:95-102.
18. Munn E.A., Smith T.S., Smith H., James F.M., Smith F.C., Andrews S.J. Vaccination against Haemonchus contortus with denatured forms of the protective antigen H11. Parasite Immunology 1997, 19:243-248.
19. Newlands G.F.J., Skuce P.J., Knox D.P., Smith W.D. Cloning and expression of cystatin: a potent protease inhibitor from the gut of Haemonchus contortus. Parasitology 2001, 122:371-378.
20. Newton S.E., Munn E.A. The development of vaccines against gastro-intestinal nematode parasites particularly Haemonchus contortus. Parasitology Today 1999, 15:116-122.
21. Nobiron I., Thompson I., Brownlie J., Collins M.E. Cytokine adjuvancy of BVDV DNA vaccine enhances both humoral and cellular immune responses in mice. Vaccine 2001, 20:4226-4235.
22. Pfeffer A., Douch P.G.C., Shaw R.J., Gatehouse T.K., Rabel B., Green R.S., Shirer C.L., Jonas W.E., Bisset S. Sequential cellular and humoral responses in the abomasal mucosa and blood of Romney sheep dosed with Trichostrongylus axei. International Journal for Parasitology 1996, 26:765-773.
23. Prichard R. Genetic variability following selection of Haemonchus contortus with anthelmintics. Trends in Parasitology 2001, 17:445-453.
24. Sin J.I., Kim J., Chattergoon M., Ayyavoo V., McCallus D., Ugen K.E. Engineering of DNA vaccines using molecular adjuvant plasmids. Developmental Biology 2000, 104:187-198.
25. Smith S.K., Pettit D., Newlands G.F.J., Redmond D.L., Skuce P.J., Knox D.P., Smith W.D. Further immunisation and biochemical studies with a protective antigen complex from the microvillar membrane of the intestine of Haemonchus contortus. Parasite Immunology 1999, 21:187-199.
26. Smooker P.M., Rainczuk A., Kennedy N., Spithill T.W. DNA vaccines and their application against parasites-promise, limitations and potential solutions. Biotechnological Annual Review 2004, 10:189-236.
27. Song H.Y., Yan R.F., Xu L.X., Song X.K., Ali M.A.S., Zhu H.L., Li X.R. Efficacy of DNA vaccines carrying Eimeria acervulina lactate hydrogenase antigen gene against coccidiosis. Experimental Parasitology 2010, 126:224-231.
28. Stear M.J., Bishop S.C., Doligalska M., Duncan J.L., Holmes P.H., Irvine J., McCririe L., McKellar Q.A., Sinski E., Murray M. Regulation of egg production, worm burden, worm length and worm fecundity by host responses in sheep infected with Ostertagia circumcincta. Parasite Immunology 1995, 17:643-652.
29. Sun Y.M., Yan R.F., Muleke C.I., Zhao G.W., Xu L.X., Li X.R. Vaccination of goats with recombinant galectin antigen induces partial protection against Haemonchus contortus infection. Parasite Immunology 2007, 29:319-326.
30. Tang D.L., DeVit M., Johnston S.A. Genetic immunization is a simple method for eliciting an immune response. Nature 1992, 356:152-154.
31. Ulmer J.B., Dewitt C.M., Chastain M., Friedman A., Donnelly J.J., McClements W.L., Cauleld M.J., Bohannon K.E., Volkin D.B., Evans R.K. Enhancement of DNA vaccine potency using conventional aluminum adjuvants. Vaccine 2000, 18:18-28.
32. Watanabe A., Raz E., Kohsaka H., Tighe H., Baird S.M., Kipps T.J. Induction of antibodies to a κ V region by gene immunization. Journal of Immunology 1993, 151:2871-2876.
33. Yacob H.T., Dorchies P.H., Jacquiet P.H., Bleuart C., Prevot F., Grisez C., Bergeaud J.P., Hoste H. Concurrent parasitic infections of sheep: depression of Trichostrongylus colubriformis populations by a subsequent infection with Oestrus ovis. Veterinary Parasitology 2004, 121:297-306.
34. Yan R.F., Xu L.X., Li X.R. Immunity of recombinant Haemonchus contortus H11 in goats, China. Journal of Veterinary Science 2007, 27:842-844.
35. Ying Q.H., Li X.R., Lu C.P. Cloning, Identification and sequencing analysis of the caprine interleukin-2(IL-2) gene. Journal of Agricultural Biotechnology 2002, 10:250-254.