Vaccination against Haemonchus contortus with denatured forms of the protective antigen H11

Parasite Immunology

Volumn 19, Issue 6, 1997, Pages 243-248

  Munn, Edward A ^a   Smith, Trevor S ^a   Smith, Howard ^a   James, Fiona M ^b,c   Smith, Fiona C ^b,d   Andrews, Stuart J ^b  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b Mallinckrodt Veterinary Ltd   (United Kingdom)

^c Arnolds Veterinary Products Ltd   (United Kingdom)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

H11; Haemonchus contortus; Immune response; Protective epitopes; Vaccination

Indexed keywords

AMINOPEPTIDASE; DITHIOTHREITOL; DODECYL SULFATE SODIUM; EPITOPE;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGEN DETECTION; ARTICLE; ENZYME ACTIVITY; HAEMONCHUS CONTORTUS; IMMUNOGENICITY; ISOELECTRIC FOCUSING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; VACCINATION;

ANIMALIA; HAEMONCHUS CONTORTUS; OVIS ARIES;

EID: 0030787590     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1997.d01-205.x     Document Type: Article

References (13)

1. Andrews S.J., Hole N.J.K., Munn E.A. & Rolph T.P. (1995) Vaccination of sheep against haemonchosis with H11, a gut membrane derived protective antigen from the adult parasite, prevention of the periparturient rise and colostral transfer of protective immunity. International Journal for Parasitology 25, 839-846
2. Feracci H., Benajiba A., Gorvel J.P., Doumeng C.H. & Maroux S. (1981) Enzymatic and immunological properties of the protease form of aminopeptidases N and A from pig and rabbit intestinal brush border. Biochimica et Biophysica Acta 658, 148-157
3. Ling I.T., Ogun S.A. & Holder A.A. (1994) Immunization against malaria with a recombinant protein. Parasite Immunology 16, 63-67
4. MAFF (1986) Manual of Veterinary Parasitological Laboratory Techniques, 3rd Edition. HMSO, London
5. Munn E.A. (1997) Rational design of nematode vaccines: hidden antigens. International Journal for Parasitology (in press)
6. Munn E.A., Smith T.S., Graham M., Tavernor A.S. & Greenwood C.A. (1993) The potential value of integral membrane proteins in the vaccination of lambs against Haemonchus contortus. International Journal for Parasitology 23, 261-269
7. Newton S.E. (1995) Progress on vaccination against Haemonchus contortus. International Journal for Parasitology 25, 1281-1289
8. Newton S.E., Morrish L.E., Martin P.J., Montague P.E & Rolph T.P. (1995) Protection against multple drug-resistant and geographically distant strains of Haemonchus contortus by vaccination with H11, a gut membrane-derived protection antigen. International Journal for Parasitology 25, 511-521
9. Smith S.K. & Smith W.D. (1996) Immunisation of sheep with an integral membrane glycoprotein complex of Haemonchus contortus and with its major polypeptide components. Research in Veterinary Science 60, 1-6
10. Smith T.S., Munn E.A., Graham M., Tavernor A.S. & Greenwood C.A. (1993) Purification and evaluation of the integral membrane protein H11 as a protective antigen against Haemonchus contortus. International Journal for Parasitology 23, 271-280
11. Smith T.S., Graham M., Munn E.A., Newton S.E., Knox D.P., Coadwell W.J., McMichael-Phillips D.F., Smith H., Smith W.D. & Oliver J.J. (1996) Cloning and characterization of a microsomal aminopeptidase from the intestine of the parasitic nematode Haemonchus. Biochimica et Biophysica Acta (in press)
12. Tavemor A.S., Smith T.S. Langford C.F., Munn E.A. & Graham M. (1992a) Vaccination of young Dorset lambs against haemonchosis. Parasite Immunology. 14, 645-655
13. Tavernor A.S., Smith T.S., Langford C.F., Graham M. & Munn E.A. (1992b) Immune response of Clun Forest sheep to vaccination with membrane glycoproteins from Haemonchus contortus. Parasite Immunology 14, 671-675