Spontaneously obese dogs exhibit greater postprandial glucose, triglyceride, and insulin concentrations than lean dogs

Domestic Animal Endocrinology

Volumn 42, Issue 2, 2012, Pages 103-112

  Verkest, K R ^a   Rand, J S ^a   Fleeman, L M ^a,b   Morton, J M ^a,c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Animal Diabetes Australia   (Australia)

^c Jemora Pty Ltd   (Australia)

Author keywords

Canine; Hyperlipidemia; Metabolic syndrome; Obesity; Type 2 diabetes

Indexed keywords

INSULIN; TRIACYLGLYCEROL;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; COHORT ANALYSIS; COMPARATIVE STUDY; DOG; DOG DISEASE; FEMALE; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; OBESITY; PANCREAS ISLET BETA CELL; POSTPRANDIAL STATE; PROSPECTIVE STUDY; STATISTICAL MODEL;

ANIMALS; BLOOD GLUCOSE; COHORT STUDIES; DOG DISEASES; DOGS; FEMALE; INSULIN; INSULIN-SECRETING CELLS; LINEAR MODELS; MALE; OBESITY; POSTPRANDIAL PERIOD; PROSPECTIVE STUDIES; TRIGLYCERIDES;

CANIS FAMILIARIS;

EID: 84855510147     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2011.10.002     Document Type: Article

References (34)

1. Polonsky K.S. Evolution of beta-cell dysfunction in impaired glucose tolerance and diabetes. Exp Clin Endocrinol Diabetes 1999, 107(suppl 4):s124-s127.
2. Del Prato S. Loss of early insulin secretion leads to postprandial hyperglycaemia. Diabetologia 2003, 46(suppl 1):M2-M8.
3. Monnier L., Lapinski H., Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c). Diabetes Care 2003, 26:881-885.
4. Toschi E., Camastra S., Sironi A.M., Masoni A., Gastaldelli A., Mari A., Ferrannini E., Natali A. Effect of acute hyperglycemia on insulin secretion in humans. Diabetes 2002, 51(suppl 1):S130-S133.
5. Poitout V. Glucolipotoxicity of the pancreatic beta-cell: myth or reality?. Biochem Soc Trans 2008, 36:901-904.
6. Leahy J.L., Bonner-Weir S., Weir G.C. Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest 1988, 81:1407-1414.
7. Bergman R.N., Kim S.P., Catalano K.J., Hsu I.R., Chiu J.D., Kabir M., Hucking K., Ader M. Why visceral fat is bad: mechanisms of the metabolic syndrome. Obesity 2006, 14:16S-19S.
8. Rand J.S., Fleeman L.M., Farrow H.A., Appleton D.J., Lederer R. Canine and feline diabetes mellitus: nature or nurture?. J Nutr 2004, 134(8 suppl):2072S-2080S.
9. Hoenig M. Comparative aspects of diabetes mellitus in dogs and cats. Mol Cell Endocrinol 2002, 197:221-229.
10. Imamura T., Koffler M., Helderman J.H., Prince D., Thirlby R., Inman L., Unger R.H. Severe diabetes induced in subtotally depancreatized dogs by sustained hyperglycemia. Diabetes 1988, 37:600-609.
11. Poitout V., Robertson R.P. Glucolipotoxicity: fuel excess and {beta}-cell dysfunction. Endocr Rev 2008, 29:351-366.
12. Chikamune T., Katamoto H., Ohashi F., Shimada Y. Serum lipid and lipoprotein concentrations in obese dogs. J Vet Med Sci 1995, 57:595-598.
13. Verkest K.R., Fleeman L.M., Rand J.S., Morton J.M. Evaluation of beta-cell sensitivity to glucose and first-phase insulin secretion in obese dogs. Am J Vet Res 2011, 72:357-366.
14. Lawler D.F., Ballam J.M., Meadows R., Larson B.T., Li Q., Stowe H.D., Kealy R.D. Influence of lifetime food restriction on physiological variables in Labrador Retriever dogs. Exp Gerontol 2007, 42:204-214.
15. Verkest K.R., Fleeman L., Morton J., Rand J.S. Compensation for obesity-induced insulin resistance in dogs: assessment of the effects of leptin, adiponectin, and glucagon-like peptide-1 using path analysis. Domest Anim Endocrinol 2011, 41:24-34.
16. German A.J., Hervera M., Hunter L., Holden S.L., Morris P.J., Biourge V., Trayhurn P. Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs. Domest Anim Endocrinol 2009, 37:214-226.
17. Laflamme D. Development and validation of a body condition score system for dogs. Canine Practice 1997, 22:10-15.
18. Hand M.S. Small animal clinical nutrition-an iterative process. Small Animal Clinical Nutrition 2010, 3-21. Mark Morris Institute, Topeka, KS. M.S. Hand, C.D. Thatcher, R.L. Remillard, P. Roudebush, B.J. Novotny (Eds.).
19. Fleeman L., Rand J. Efficacy of intermittent low-dose heparinised saline flushes for maintaining indwelling peripheral and central intravenous catheters in diabetic dogs. Aust Vet Pract 2001, 31(3):126-134.
20. Verkest K.R., Fleeman L.M., Rand J.S., Morton J.M. Basal measures of insulin sensitivity and insulin secretion and simplified glucose tolerance tests in dogs. Domest Anim Endocrinol 2010, 39:194-204.
21. Wilcox R.R., Charlin V.L., Thompson K.L. New Monte Carlo results on the robustness of the ANOVA F, W and F statistics. Communications Statist-simul Comput 1986, 15:933-943.
22. Leahy J.L., Cooper H.E., Deal D.A., Weir G.C. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. J Clin Invest 1986, 77:908-915.
23. Unger R.H., Grundy S. Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes. Diabetologia 1985, 28(3):119-121.
24. Kashyap S., Belfort R., Gastaldelli A., Pratipanawatr T., Berria R., Pratipanawatr W., Bajaj M., Mandarino L., Defronzo R., Cusi K. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes 2003, 52:2461-2474.
25. Van Citters G.W., Kabir M., Kim S.P., Mittelman S.D., Dea M.K., Brubaker P.L., Bergman R.N. Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding. J Clin Endocrinol Metab 2002, 87:5191-5198.
26. Mittelman S.D., Van Citters G.W., Kim S.P., Davis D.A., Dea M.K., Hamilton-Wessler M., Bergman R.N. Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes 2000, 49:2116-2125.
27. Gredal C., Rosenfalck A.M., Dejgaard A., Hilsted J. Impaired first-phase insulin response predicts postprandial blood glucose increment in patients with recently diagnosed type 2 diabetes. Scand J Clin Lab Invest 2007, 67:327-336.
28. Fonseca V.A. Defining and characterizing the progression of type 2 diabetes. Diabetes Care 2009, 32(suppl 2):S151-S156.
29. Chapter 4, Model bill and regulations. 2010 Official Publication Association of American Feed Control Officials 2010, 95-189. AAFCO, AAFCO, Oxford, IN.
30. Diagnosis and classification of diabetes mellitus. Diabetes Care 2008, 31:S55-S60. The American Diabetes Association.
31. Committee I.E. International Expert Committee report on the role of the a1c assay in the diagnosis of diabetes. Diabetes Care 2009, 32:1327-1334.
32. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997, 20(7):1183-1197. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus.
33. Weir G.C., Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 2004, 53:s16-s21.
34. Catchpole B., Ristic J.M., Fleeman L.M., Davison L.J. Canine diabetes mellitus: can old dogs teach us new tricks?. Diabetologia 2005, 48:1948-1956.