Compensation for obesity-induced insulin resistance in dogs: Assessment of the effects of leptin, adiponectin, and glucagon-like peptide-1 using path analysis

Domestic Animal Endocrinology

Volumn 41, Issue 1, 2011, Pages 24-34

  Verkest, K R ^a   Fleeman, L M ^a   Morton, J M ^a   Ishioka, K ^b   Rand, J S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b NIPPON VETERINARY AND LIFE SCIENCE UNIVERSITY   (Japan)

Author keywords

Adipokine, Insulin sensitivity; Insulin secretion; Obesity; Type 2 diabetes mellitus

Indexed keywords

ADIPONECTIN; GLUCAGON LIKE PEPTIDE 1; INSULIN; LEPTIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; DIET RESTRICTION; DOG; DOG DISEASE; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; OBESITY; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADIPONECTIN; ADIPOSITY; ANIMALS; BLOOD GLUCOSE; DOG DISEASES; DOGS; FASTING; GLUCAGON-LIKE PEPTIDE 1; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LEPTIN; OBESITY;

CANIS FAMILIARIS;

EID: 79958007916     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.domaniend.2011.02.001     Document Type: Article

References (48)

1. Kil D., Swanson K. Endocrinology of obesity. Vet Clin North Am Small Anim Pract 2010, 40:205-219.
2. Bergman R.N., Van Citters G.W., et al. Central role of the adipocyte in the metabolic syndrome. J Investig Med 2001, 49:119-126.
3. Ishioka K., Soliman M.M., Sagawa M., et al. Experimental and clinical studies on plasma leptin in obese dogs. J Vet Med Sci 2002, 64:349-353.
4. Ishioka K., Omachi A., Sagawa M., et al. Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity. Res Vet Sci 2006, 80:127-132.
5. German A.J., Hervera M., Hunter L., et al. Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs. Domest Anim Endocrinol 2009, 37:214-226.
6. Mittelman S.D., Van Citters G.W., et al. Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes 2000, 49:2116-2125.
7. Havel P.J. Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med 2001, 226:963-977.
8. Havel P.J. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol 2002, 13:51-59.
9. Wang M.Y., Koyama K., Shimabukuro M., Mangelsdorf D., Newgard C.B., Unger R.H. Overexpression of leptin receptors in pancreatic islets of zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A 1998, 95:11921-11926.
10. Tartaglia L.A., Dembski M., Weng X., et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995, 83:1263-1271.
11. Pajvani U.B., Scherer P.E. Adiponectin: systemic contributor to insulin sensitivity. Curr Diab Rep 2003, 3:207-213.
12. Tschritter O., Fritsche A., Thamer C., et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003, 52:239-243.
13. Lusby A.L. Characterization of feline adiponectin and its association with metabolic indices in lean and obese cats (thesis) 2009, University of Tennessee, Knoxville.
14. Yamauchi T., Kamon J., Ito Y., et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423:762-769.
15. Van Citters G.W., Kabir M., Kim S.P., et al. Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding. J Clin Endocrinol Metab 2002, 87:5191-5198.
16. Diagnosis and classification of diabetes mellitus. Diabetes Care 2008, 31(suppl):S55-S60. The American Diabetes Association.
17. Rand J.S., Fleeman L.M., Farrow H.A., Appleton D.J., Lederer R. Canine and feline diabetes mellitus: nature or nurture?. J Nutr 2004, 134(8 Suppl):2072S-2080S.
18. Verkest K.R., Fleeman L.M., Rand J.S., Morton J.M. Evaluation of beta-cell sensitivity to glucose and first-phase insulin secretion in obese dogs. Am J Vet Res 2011, 72:357-366.
19. Kaiyala K.J., Prigeon R.L., Kahn S.E., Woods S.C., Porte D., Schwartz M.W. Reduced beta-cell function contributes to impaired glucose tolerance in dogs made obese by high-fat feeding. Am J Physiol 1999, 277(4 Pt 1):E659-E667.
20. Laflamme D. Development and validation of a body condition score system for dogs. Canine Practice 1997, 22:10-15.
21. Levy J.C., Matthews D.R., Hermans M.P. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998, 21:2191-2192.
22. Verkest K.R., Fleeman L., Rand J.S., Morton J. Basal measures of insulin sensitivity and insulin secretion and simplified glucose tolerance tests in dogs. Domest Anim Endocrinol 2010, 39:194-204.
23. Landis R.S. Standardized regression coefficients 2005, John Wiley & Sons, Ltd, New York.
24. Larson B.T., Lawler D.F., Spitznagel E.L., Kealy R.D. Improved glucose tolerance with lifetime diet restriction favorably affects disease and survival in dogs. J Nutr 2003, 133:2887-2892.
25. Mattheeuws D., Rottiers R., Kaneko J.J., Vermeulen A. Diabetes mellitus in dogs: relationship of obesity to glucose tolerance and insulin response. Am J Vet Res 1984, 45:98-103.
26. Eigenmann J.E., Eigenmann R.Y., Rijnberk A., Van Der Gaag I., Zapf J., Froesch E.R. Progesterone-controlled growth hormone overproduction and naturally occurring canine diabetes and acromegaly. Acta Endocrinol (Copenh) 1983, 104:167-176.
27. Fall T., Johansson Kreuger S., Juberget A., Bergstrom A., Hedhammar A. Gestational diabetes mellitus in 13 dogs. J Vet Intern Med 2008, 22:12961130.
28. Ceddia R.B., Koistinen H.A., Zierath J.R., Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J 2002, 16:1163-1176.
29. Islam M.S., Sjöholm , Emilsson V. Fetal pancreatic islets express functional leptin receptors and leptin stimulates proliferation of fetal islet cells. Int J Obes 2000, 24:1246-1253.
30. Gray S.L., Donald C., Jetha A., Covey S.D., Kieffer T.J. Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic {beta}-cell leptin signaling. Endocrinology 2010, 151:4178-4186.
31. Morioka T., Asilmaz E., Hu J., et al. Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice. J Clin Invest 2007, 117:2860-2868.
32. Koyama K., Chen G., Wang M.Y., et al. Beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Diabetes 1997, 46(8):1276-1280.
33. Emilsson V., Liu Y., Cawthorne M., Morton N., Davenport M. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 1997, 46(2):313-316.
34. Kieffer T.J., Heller R.S., Leech C.A., Holz G.G., Habener J.F. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes 1997, 46(6):1087-1093.
35. Shimabukuro M., Wang M.-Y., Zhou Y.-T., Newgard C.B., Unger R.H. Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of BCL-2 expression. Proc Natl Acad Sci U S A 1998, 95:9558-9561.
36. Pelleymounter M., Cullen M., Baker M., et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995, 269:540-543.
37. Burcelin R., Serino M., Cabou C. A role for the gut-to-brain GLP-1-dependent axis in the control of metabolism. Curr Opin Pharmacol 2009, 9:744-752.
38. Wang M.Y., Koyama K., Shimabukuro M., Newgard C.B., Unger R.H. OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. Proc Natl Acad Sci U S A 1998, 95:714-718.
39. Ishioka K., Hatai H., Komabayashi K., et al. Diurnal variation of serum leptin in dogs - effects of fasting and refeeding. Vet J 2005, 169:85-90.
40. Abdul-Ghani M.A., Tripathy D., Defronzo R.A. Contributions of {beta}-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care 2006, 29:1130-1139.
41. Levy J., Morris R., Hammersley M., Turner R. Discrimination, adjusted correlation, and equivalence of imprecise tests: application to glucose tolerance. Am J Physiol 1999, 276:E365-E375.
42. Wakshlag J., Struble A., Levine C., Bushey J., Laflamme D.P., Long G. Effects of weight loss on adipokines and markers of inflammation in dogs (abstract). The WALTHAM International Nutritional Sciences Symposium Pet Nutrition - Art or Science? September 16-18 2010, Waltham International Nutritional Sciences, Cambridge, UK.
43. Verkest K.R., Rose F.J., Fleeman L.M., et al. Adiposity and adiponectin in dogs: investigation of causes of discrepant results between two studies. Domest Anim Endocrinol 2011, 41:275-281.
44. Kielar D., Clark J.S.C., Ciechanowicz A., Kurzawski G., Sulikowski T., Naruszewicz M. Leptin receptor isoforms expressed in human adipose tissue. Metabolism 1998, 47:844-847.
45. Gavrila A., Chan J.L., Yiannakouris N., et al. Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: Cross-sectional and interventional studies. J Clin Endocrinol Metab 2003, 88:4823-4831.
46. Greenland S., Brumback B. An overview of relations among causal modelling methods. Int J Epidemiol 2002, 31:1030-1037.
47. Lund E.M., Armstrong P.J., Kirk C.A., Klausner J.S. Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. Intern J Appl Res Vet Med 2006, 4:177-186.
48. Martin W. Linking causal concepts, study design, analysis and inference in support of one epidemiology for population health. Prev Vet Med 2008, 86:270-288.