Mechanism-inspired engineering of phenylalanine aminomutase for enhanced β-regioselective asymmetric amination of cinnamates

Angewandte Chemie - International Edition

Volumn 51, Issue 2, 2012, Pages 482-486

  Wu, Bian ^a   Szymański, Wiktor ^b   Wybenga, Gjalt G ^a   Heberling, Matthew M ^a   Bartsch, Sebastian ^a   Dewildeman, Stefaan ^c   Poelarends, Gerrit J ^d   Feringa, Ben L ^b   Dijkstra, Bauke W ^a   Janssen, Dick B ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c DSM Pharmaceutical Products   (Netherlands)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

aminomutase; directed evolution; enzyme catalysis; regioselectivity; amino acids

Indexed keywords

AMINES; AMINO ACIDS; BINDING ENERGY; CARBOXYLATION; REGIOSELECTIVITY;

AMINOMUTASE; BETA AMINO ACIDS; BINDING MODES; BOND ROTATIONS; DIRECTED EVOLUTION; ENZYME CATALYSIS; REGIO-SELECTIVE; X RAY CRYSTAL STRUCTURES;

AMINATION;

EID: 84855466060     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201106372     Document Type: Article

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