Mutational analysis of phenylalanine ammonia lyase to improve reactions rates for various substrates

Protein Engineering, Design and Selection

Volumn 23, Issue 12, 2010, Pages 929-933

  Bartsch, Sebastian ^a   Bornscheuer, Uwe T ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

amino acids; enzyme catalysis; molecular modeling; protein design; substrate specificity

Indexed keywords

AMINATION REACTION; AMMONIA CONCENTRATIONS; ASYMMETRIC SYNTHESIS; CINNAMIC ACIDS; CO-FACTOR RECYCLING; DIRECTED EVOLUTION; ELECTRONIC EFFECTS; ENZYME CATALYSIS; H-BOND NETWORK; INDUSTRIAL PROCESSS; L-PHENYLALANINE; MUTATIONAL ANALYSIS; PHENYLALANINE AMMONIA-LYASE; PROTEIN DESIGN; REACTIONS RATES; REDUCTIVE AMINATION; SUBSTRATE INHIBITION; SUBSTRATE SPECIFICITY; THEORETICAL YIELD; TRANS-CINNAMIC ACID; VARIOUS SUBSTRATES;

AMINATION; AMINES; AMINO ACIDS; AMMONIA; BINDING ENERGY; CARBOXYLIC ACIDS; CATALYSIS; ENZYMES; MOLECULAR MODELING; SUBSTRATES; SYNTHESIS (CHEMICAL);

REACTION RATES;

4 NITRO CINNAMIC ACID; CINNAMIC ACID DERIVATIVE; PHENYLALANINE AMMONIA LYASE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; BINDING SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; HYDROGEN BOND; MUTATIONAL ANALYSIS; NONHUMAN; PARSLEY; PRIORITY JOURNAL; PROTEIN FOLDING; SUBSTITUTION REACTION;

AMINES; BINDING SITES; BIOCATALYSIS; CARBOXYLIC ACIDS; CINNAMATES; DIRECTED MOLECULAR EVOLUTION; DNA MUTATIONAL ANALYSIS; KINETICS; MODELS, MOLECULAR; MUTATION; PETROSELINUM; PHENYLALANINE AMMONIA-LYASE; SUBSTRATE SPECIFICITY;

PETROSELINUM CRISPUM;

EID: 78649240495     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq089     Document Type: Article

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