메뉴 건너뛰기




Volumn 220, Issue 2, 2012, Pages 122-130

Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: Promise or reality?

Author keywords

Amyotrophic lateral sclerosis; In vitro model; Neuromuscular junction; Spinal muscular atrophy; Stem cells

Indexed keywords

COCULTURE; DISEASE MODEL; HUMAN; MOTOR NEURON DISEASE; MUSCLE FIBER CULTURE; NERVE CELL CULTURE; NEUROMUSCULAR SYNAPSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW;

EID: 84855447114     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/j.1469-7580.2011.01459.x     Document Type: Review
Times cited : (35)

References (73)
  • 1
    • 60649084367 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: current progress and potential for regenerative medicine
    • Amabile G, Meissner A (2009) Induced pluripotent stem cells: current progress and potential for regenerative medicine. Trends Mol Med 15, 59-68.
    • (2009) Trends Mol Med , vol.15 , pp. 59-68
    • Amabile, G.1    Meissner, A.2
  • 2
    • 0038724202 scopus 로고    scopus 로고
    • Human feeder layers for human embryonic stem cells
    • Amit M, Margulets V, Segev H, etal. (2003) Human feeder layers for human embryonic stem cells. Biol Reprod 68, 2150-2156.
    • (2003) Biol Reprod , vol.68 , pp. 2150-2156
    • Amit, M.1    Margulets, V.2    Segev, H.3
  • 3
    • 1242276404 scopus 로고    scopus 로고
    • Feeder layer- and serum-free culture of human embryonic stem cells
    • Amit M, Shariki C, Margulets V, etal. (2004) Feeder layer- and serum-free culture of human embryonic stem cells. Biol Reprod 70, 837-845.
    • (2004) Biol Reprod , vol.70 , pp. 837-845
    • Amit, M.1    Shariki, C.2    Margulets, V.3
  • 4
    • 34249658366 scopus 로고    scopus 로고
    • Derivation of engraftable skeletal myoblasts from human embryonic stem cells
    • Barberi T, Bradbury M, Dincer Z, etal. (2007) Derivation of engraftable skeletal myoblasts from human embryonic stem cells. Nat Med 13, 642-648.
    • (2007) Nat Med , vol.13 , pp. 642-648
    • Barberi, T.1    Bradbury, M.2    Dincer, Z.3
  • 5
    • 84998275870 scopus 로고
    • Anatomical studies of mouse embryo spinal cord-skeletal muscle in long-term tissue culture
    • Bornstein MB, Breitbart LM (1964) Anatomical studies of mouse embryo spinal cord-skeletal muscle in long-term tissue culture. Anat Rec 148, 362.
    • (1964) Anat Rec , vol.148 , pp. 362
    • Bornstein, M.B.1    Breitbart, L.M.2
  • 6
    • 0028947081 scopus 로고
    • Constitutive muscular abnormalities in culture in spinal muscular atrophy
    • Braun S, Croizat B, Lagrange MC, etal. (1995) Constitutive muscular abnormalities in culture in spinal muscular atrophy. Lancet 345, 694-695.
    • (1995) Lancet , vol.345 , pp. 694-695
    • Braun, S.1    Croizat, B.2    Lagrange, M.C.3
  • 7
    • 71749091926 scopus 로고    scopus 로고
    • Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model
    • Cifuentes-Diaz C, Nicole S, Velasco ME, etal. (2002) Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model. Hum Mol Genet 11, 1439-1447.
    • (2002) Hum Mol Genet , vol.11 , pp. 1439-1447
    • Cifuentes-Diaz, C.1    Nicole, S.2    Velasco, M.E.3
  • 8
    • 59349090981 scopus 로고    scopus 로고
    • Identity, developmental restriction and reactivity of extralaminar cells capping mammalian neuromuscular junctions
    • Court FA, Gillingwater TH, Melrose S, etal. (2008) Identity, developmental restriction and reactivity of extralaminar cells capping mammalian neuromuscular junctions. J Cell Sci 121, 3901-3911.
    • (2008) J Cell Sci , vol.121 , pp. 3901-3911
    • Court, F.A.1    Gillingwater, T.H.2    Melrose, S.3
  • 9
    • 84855460298 scopus 로고
    • Electrophysiological studies of cord-innervated skeletal muscle in long-term tissue cultures of mouse embryo myotomes
    • Crain SM (1964) Electrophysiological studies of cord-innervated skeletal muscle in long-term tissue cultures of mouse embryo myotomes. Anat Rec 148, 273-274.
    • (1964) Anat Rec , vol.148 , pp. 273-274
    • Crain, S.M.1
  • 10
    • 84855455544 scopus 로고
    • Development of functional neuromuscular connections between separate explants of fetal mammalian tissues after maturation in culture
    • Crain SM (1968) Development of functional neuromuscular connections between separate explants of fetal mammalian tissues after maturation in culture. Anat Rec 160, 466.
    • (1968) Anat Rec , vol.160 , pp. 466
    • Crain, S.M.1
  • 11
    • 0014885729 scopus 로고
    • Neuromuscular transmission in cultures of adult human and rodent skeletal muscle after innervation in vitro by fetal rodent spinal cord
    • Crain SM, Alfei L, Peterson ER (1970) Neuromuscular transmission in cultures of adult human and rodent skeletal muscle after innervation in vitro by fetal rodent spinal cord. J Neurobiol 1, 471-489.
    • (1970) J Neurobiol , vol.1 , pp. 471-489
    • Crain, S.M.1    Alfei, L.2    Peterson, E.R.3
  • 12
    • 50149098605 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
    • Dimos JT, Rodolfa KT, Niakan KK, etal. (2008) Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Nature 321, 1218-1221.
    • (2008) Nature , vol.321 , pp. 1218-1221
    • Dimos, J.T.1    Rodolfa, K.T.2    Niakan, K.K.3
  • 13
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient
    • Ebert AD, Yu J, Rose FF, etal. (2009) Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 457, 277-281.
    • (2009) Nature , vol.457 , pp. 277-281
    • Ebert, A.D.1    Yu, J.2    Rose, F.F.3
  • 14
    • 67349271683 scopus 로고    scopus 로고
    • Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behaviour
    • Feiguin F, Godena VK, Romano G, etal. (2009) Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behaviour. FEBS Lett 583, 1586-1592.
    • (2009) FEBS Lett , vol.583 , pp. 1586-1592
    • Feiguin, F.1    Godena, V.K.2    Romano, G.3
  • 15
    • 55749098985 scopus 로고    scopus 로고
    • Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-β1
    • Feng Z, Ko C-P (2008) Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-β1. J Neurosci 28, 9599-9609.
    • (2008) J Neurosci , vol.28 , pp. 9599-9609
    • Feng, Z.1    Ko, C.-P.2
  • 16
    • 0344950387 scopus 로고    scopus 로고
    • Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease
    • Ferri A, Sanes JR, Coleman MP, etal. (2003) Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease. Curr Biol 13, 669-673.
    • (2003) Curr Biol , vol.13 , pp. 669-673
    • Ferri, A.1    Sanes, J.R.2    Coleman, M.P.3
  • 17
    • 0014962734 scopus 로고
    • Synaptic potentials recorded in cell cultures of nerve and muscle
    • Fischbach GD (1970) Synaptic potentials recorded in cell cultures of nerve and muscle. Science 169, 1331-1333.
    • (1970) Science , vol.169 , pp. 1331-1333
    • Fischbach, G.D.1
  • 18
    • 0345742771 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man
    • Fischer LR, Culver DG, Tennant P, etal. (2004) Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp Neurol 185, 232-240.
    • (2004) Exp Neurol , vol.185 , pp. 232-240
    • Fischer, L.R.1    Culver, D.G.2    Tennant, P.3
  • 19
    • 0034175513 scopus 로고    scopus 로고
    • Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases
    • Frey D, Scheider C, Xu L, etal. (2000) Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases. J Neurosci 20, 2534-2542.
    • (2000) J Neurosci , vol.20 , pp. 2534-2542
    • Frey, D.1    Scheider, C.2    Xu, L.3
  • 20
    • 41849090089 scopus 로고    scopus 로고
    • Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect
    • Gavrilina TO, McGovern VL, Workman E, etal. (2008) Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect. Hum Mol Genet 17, 1063-1075.
    • (2008) Hum Mol Genet , vol.17 , pp. 1063-1075
    • Gavrilina, T.O.1    McGovern, V.L.2    Workman, E.3
  • 21
    • 33748261830 scopus 로고    scopus 로고
    • Complete dissociation of motor neuron death from motor dysfunction by bax deletion in a mouse model of ALS
    • Gould TW, Buss RR, Vinsant S, etal. (2006) Complete dissociation of motor neuron death from motor dysfunction by bax deletion in a mouse model of ALS. J Neurosci 26, 8774-8786.
    • (2006) J Neurosci , vol.26 , pp. 8774-8786
    • Gould, T.W.1    Buss, R.R.2    Vinsant, S.3
  • 22
    • 78649679450 scopus 로고    scopus 로고
    • Neuromuscular junction formation between human stem-cell-derived motoneurons and rat skeletal muscle in a defined system
    • Guo X, Das M, Rumsey J, etal. (2010) Neuromuscular junction formation between human stem-cell-derived motoneurons and rat skeletal muscle in a defined system. Tissue Eng Part C Methods 16, 1347-1355.
    • (2010) Tissue Eng Part C Methods , vol.16 , pp. 1347-1355
    • Guo, X.1    Das, M.2    Rumsey, J.3
  • 23
    • 84979135771 scopus 로고
    • Observations on the living developing nerve fibre
    • Harrison RG (1907) Observations on the living developing nerve fibre. Anat Rec 1, 116-128.
    • (1907) Anat Rec , vol.1 , pp. 116-128
    • Harrison, R.G.1
  • 24
    • 0023387512 scopus 로고
    • Extracts of muscle biopsies from patients with spinal muscular atrophies inhibit neurite outgrowth from spinal cords
    • Henderson CE, Hauser SL, Huchet M, etal. (1987) Extracts of muscle biopsies from patients with spinal muscular atrophies inhibit neurite outgrowth from spinal cords. Neurology 37, 1361-1364.
    • (1987) Neurology , vol.37 , pp. 1361-1364
    • Henderson, C.E.1    Hauser, S.L.2    Huchet, M.3
  • 25
    • 70249133666 scopus 로고    scopus 로고
    • Differentiation of spinal motor neurons from pluripotent human stem cells
    • Hu B, Zhang S (2009) Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc 4, 1295.
    • (2009) Nat Protoc , vol.4 , pp. 1295
    • Hu, B.1    Zhang, S.2
  • 26
    • 77955843524 scopus 로고    scopus 로고
    • Neurodegenerative disease-specific induced pluripotent stem cell research
    • Inoue H (2010) Neurodegenerative disease-specific induced pluripotent stem cell research. Exp Cell Res 316, 2560-2564.
    • (2010) Exp Cell Res , vol.316 , pp. 2560-2564
    • Inoue, H.1
  • 27
    • 0014431330 scopus 로고
    • De novo formation of neuro-muscular junctions in tissue culture
    • James DW, Tresman RL (1968) De novo formation of neuro-muscular junctions in tissue culture. Nature 220, 384-385.
    • (1968) Nature , vol.220 , pp. 384-385
    • James, D.W.1    Tresman, R.L.2
  • 28
    • 0034303585 scopus 로고    scopus 로고
    • Neuronal specification in the spinal cord: inductive signals and transcriptional codes
    • Jessell TM (2000) Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Gen 1, 20-29.
    • (2000) Nat Rev Gen , vol.1 , pp. 20-29
    • Jessell, T.M.1
  • 30
    • 48249145306 scopus 로고    scopus 로고
    • Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy
    • Kariya S, Park GH, Maeno-Hikichi Y, etal. (2008) Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. Hum Mol Genet 17, 2552-2569.
    • (2008) Hum Mol Genet , vol.17 , pp. 2552-2569
    • Kariya, S.1    Park, G.H.2    Maeno-Hikichi, Y.3
  • 31
    • 12144277093 scopus 로고    scopus 로고
    • Musculoskeletal differentiation of cells derived from human embryonic germ cells
    • Kim MS, Hwang NS, Lee J, etal. (2005) Musculoskeletal differentiation of cells derived from human embryonic germ cells. Stem Cells 23, 113-123.
    • (2005) Stem Cells , vol.23 , pp. 113-123
    • Kim, M.S.1    Hwang, N.S.2    Lee, J.3
  • 32
    • 3042668901 scopus 로고    scopus 로고
    • Roles of glial cells in the formation, function, and maintenance of the neuromuscular junction
    • Koirala S, Reddy LV, Ko C-P (2003) Roles of glial cells in the formation, function, and maintenance of the neuromuscular junction. J Neurocytol 32, 987-1002.
    • (2003) J Neurocytol , vol.32 , pp. 987-1002
    • Koirala, S.1    Reddy, L.V.2    Ko, C.-P.3
  • 33
    • 58849103600 scopus 로고    scopus 로고
    • Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice
    • Kong L, Wang X, Choe DW, etal. (2009) Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice. J Neurosci 29, 842-851.
    • (2009) J Neurosci , vol.29 , pp. 842-851
    • Kong, L.1    Wang, X.2    Choe, D.W.3
  • 34
    • 70349301819 scopus 로고    scopus 로고
    • Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
    • Lee G, Papapetrou EP, Kim H, etal. (2009) Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature 461, 402-406.
    • (2009) Nature , vol.461 , pp. 402-406
    • Lee, G.1    Papapetrou, E.P.2    Kim, H.3
  • 35
    • 13844271605 scopus 로고    scopus 로고
    • Specification of motoneurons from human embryonic stem cells
    • Li X-J, Du Z-W, Zarnowska ED, etal. (2005) Specification of motoneurons from human embryonic stem cells. Nat Biotechnol 23, 215-221.
    • (2005) Nat Biotechnol , vol.23 , pp. 215-221
    • Li, X.-J.1    Du, Z.-W.2    Zarnowska, E.D.3
  • 36
    • 0016707166 scopus 로고
    • The effect of serum for ALS patients on organotypic nerve and muscle tissue cultures
    • Liveson J, Frey H, Bornstein MB (1975) The effect of serum for ALS patients on organotypic nerve and muscle tissue cultures. Acta Neuropathol 32, 127-131.
    • (1975) Acta Neuropathol , vol.32 , pp. 127-131
    • Liveson, J.1    Frey, H.2    Bornstein, M.B.3
  • 38
    • 45249106162 scopus 로고    scopus 로고
    • Spinal muscular atrophy
    • Lunn MR, Wang CH (2008) Spinal muscular atrophy. Lancet 371, 2120-2133.
    • (2008) Lancet , vol.371 , pp. 2120-2133
    • Lunn, M.R.1    Wang, C.H.2
  • 39
    • 80155144126 scopus 로고    scopus 로고
    • Induced pluripotent stem cells (iPSC) and neurologic disease modeling: progress and promises
    • Marchetto MC, Brennand KJ, Boyer L, etal. (2011) Induced pluripotent stem cells (iPSC) and neurologic disease modeling: progress and promises. Hum Mol Genet 20, R109-R115.
    • (2011) Hum Mol Genet , vol.20
    • Marchetto, M.C.1    Brennand, K.J.2    Boyer, L.3
  • 40
    • 79954418381 scopus 로고    scopus 로고
    • Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy
    • Marteyn A, Maury Y, Gauthier MM, etal. (2011) Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy. Cell Stem Cell 8, 434-444.
    • (2011) Cell Stem Cell , vol.8 , pp. 434-444
    • Marteyn, A.1    Maury, Y.2    Gauthier, M.M.3
  • 41
    • 33845876647 scopus 로고    scopus 로고
    • Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis
    • Miller TM, Kim SH, Yamanaka K, etal. (2006) Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 103, 19546-19551.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 19546-19551
    • Miller, T.M.1    Kim, S.H.2    Yamanaka, K.3
  • 42
    • 41149113045 scopus 로고    scopus 로고
    • Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy
    • Murray LM, Comley LH, Thomson D, etal. (2008) Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy. Hum Mol Genet 17, 949-962.
    • (2008) Hum Mol Genet , vol.17 , pp. 949-962
    • Murray, L.M.1    Comley, L.H.2    Thomson, D.3
  • 43
    • 77949909934 scopus 로고    scopus 로고
    • Review: neuromuscular synaptic vulnerability in motor neuron disease: amyotrophic lateral sclerosis and spinal muscular atrophy
    • Murray LM, Talbot K, Gillingwater TH (2010a) Review: neuromuscular synaptic vulnerability in motor neuron disease: amyotrophic lateral sclerosis and spinal muscular atrophy. Neuropathol Appl Neurobiol 36, 133-156.
    • (2010) Neuropathol Appl Neurobiol , vol.36 , pp. 133-156
    • Murray, L.M.1    Talbot, K.2    Gillingwater, T.H.3
  • 44
    • 77949889554 scopus 로고    scopus 로고
    • Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy
    • Murray LM, Lee S, Baumer D, etal. (2010b) Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy. Hum Mol Genet 19, 420-433.
    • (2010) Hum Mol Genet , vol.19 , pp. 420-433
    • Murray, L.M.1    Lee, S.2    Baumer, D.3
  • 45
    • 80054880080 scopus 로고    scopus 로고
    • Reversible molecular pathology of skeletal muscle in spinal muscular atrophy
    • Mutsaers CA, Wishart TM, Lamont DJ, etal. (2011) Reversible molecular pathology of skeletal muscle in spinal muscular atrophy. Hum Mol Genet 20, 4334-4344.
    • (2011) Hum Mol Genet , vol.20 , pp. 4334-4344
    • Mutsaers, C.A.1    Wishart, T.M.2    Lamont, D.J.3
  • 46
    • 0015226959 scopus 로고
    • Electron microscopy of the in vitro development of mammalian motor endplates
    • Pappas GD, Peterson ER, Masurovsky EB, etal. (1971) Electron microscopy of the in vitro development of mammalian motor endplates. Ann N Y Acad Sci 183, 33-45.
    • (1971) Ann N Y Acad Sci , vol.183 , pp. 33-45
    • Pappas, G.D.1    Peterson, E.R.2    Masurovsky, E.B.3
  • 47
    • 70350191753 scopus 로고    scopus 로고
    • Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity
    • Patani R, Compston A, Puddifoot CA, etal. (2009) Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. PLoS ONE 4, e7327.
    • (2009) PLoS ONE , vol.4
    • Patani, R.1    Compston, A.2    Puddifoot, C.A.3
  • 48
    • 79952345580 scopus 로고    scopus 로고
    • Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state
    • Patani R, Hollins AJ, Wishart TM, etal. (2011) Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state. Nat Comm 2, 1-10.
    • (2011) Nat Comm , vol.2 , pp. 1-10
    • Patani, R.1    Hollins, A.J.2    Wishart, T.M.3
  • 49
    • 77956205121 scopus 로고    scopus 로고
    • Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation
    • Peljto M, Dasen JS, Mazzoni EO, etal. (2010) Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation. Cell Stem Cell 7, 355-366.
    • (2010) Cell Stem Cell , vol.7 , pp. 355-366
    • Peljto, M.1    Dasen, J.S.2    Mazzoni, E.O.3
  • 50
    • 0038452670 scopus 로고    scopus 로고
    • Differential effects of neurotrophins and Schwann cell-derived signals on neuronal survival/growth and synaptogenesis
    • Peng HB, Yang J-F, Dai Z, etal. (2003) Differential effects of neurotrophins and Schwann cell-derived signals on neuronal survival/growth and synaptogenesis. J Neurosci 23, 5050-5060.
    • (2003) J Neurosci , vol.23 , pp. 5050-5060
    • Peng, H.B.1    Yang, J.-F.2    Dai, Z.3
  • 51
    • 0014723531 scopus 로고
    • Innervation in cultures of fetal rodent skeletal muscle by organotypic explants of spinal cord from different animals
    • Peterson ER, Crain SM (1970) Innervation in cultures of fetal rodent skeletal muscle by organotypic explants of spinal cord from different animals. Cell Tissue Res 106, 1-21.
    • (1970) Cell Tissue Res , vol.106 , pp. 1-21
    • Peterson, E.R.1    Crain, S.M.2
  • 52
    • 0015370796 scopus 로고
    • Regeneration and innervations in cultures of adult mammalian skeletal muscle coupled with fetal rodent spinal cord
    • Peterson ER, Crain SM (1972) Regeneration and innervations in cultures of adult mammalian skeletal muscle coupled with fetal rodent spinal cord. Exp Neurol 36, 136-159.
    • (1972) Exp Neurol , vol.36 , pp. 136-159
    • Peterson, E.R.1    Crain, S.M.2
  • 53
    • 0022502734 scopus 로고
    • Duchenne dystrophic muscle develops lesions in long-term coculture with mouse spinal cord
    • Peterson ER, Masurovsky EB, Spiro AJ, etal. (1986) Duchenne dystrophic muscle develops lesions in long-term coculture with mouse spinal cord. Muscle Nerve 9, 787-808.
    • (1986) Muscle Nerve , vol.9 , pp. 787-808
    • Peterson, E.R.1    Masurovsky, E.B.2    Spiro, A.J.3
  • 54
    • 77956496676 scopus 로고    scopus 로고
    • A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease
    • Ramesh T, Lyon AN, Pineda RH, etal. (2010) A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease. Dis Model Mech 3, 652-662.
    • (2010) Dis Model Mech , vol.3 , pp. 652-662
    • Ramesh, T.1    Lyon, A.N.2    Pineda, R.H.3
  • 55
    • 0036900980 scopus 로고    scopus 로고
    • Reduced neuromuscular quantal content with normal synaptic release time course and depression in canine motor neuron disease
    • Rich MM, Wang X, Cope TC, etal. (2002) Reduced neuromuscular quantal content with normal synaptic release time course and depression in canine motor neuron disease. J Neurophysiol 88, 3305-3314.
    • (2002) J Neurophysiol , vol.88 , pp. 3305-3314
    • Rich, M.M.1    Wang, X.2    Cope, T.C.3
  • 56
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen DR, Siddique T, Patterson D, etal. (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59-62.
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3
  • 57
    • 60849093466 scopus 로고    scopus 로고
    • Current hypotheses for the underlying biology of amyotrophic lateral sclerosis
    • Rothstein JD (2009) Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol 65, S3-S9.
    • (2009) Ann Neurol , vol.65
    • Rothstein, J.D.1
  • 58
    • 34548190615 scopus 로고    scopus 로고
    • Spinal muscular atrophy: clinical classification and disease heterogeneity
    • Russman BS (2007) Spinal muscular atrophy: clinical classification and disease heterogeneity. J Child Neurol 22, 946-951.
    • (2007) J Child Neurol , vol.22 , pp. 946-951
    • Russman, B.S.1
  • 59
    • 0032936983 scopus 로고    scopus 로고
    • Development of the vertebrate neuromuscular junction
    • Sanes JR, Lichtman JW (1999) Development of the vertebrate neuromuscular junction. Annu Rev Neurosci 22, 389-442.
    • (1999) Annu Rev Neurosci , vol.22 , pp. 389-442
    • Sanes, J.R.1    Lichtman, J.W.2
  • 60
    • 38449113556 scopus 로고    scopus 로고
    • Genetics of sporadic amyotrophic lateral sclerosis
    • Schymick JC, Talbot K, Traynor BJ (2007) Genetics of sporadic amyotrophic lateral sclerosis. Hum Mol Genet 16, 233-242.
    • (2007) Hum Mol Genet , vol.16 , pp. 233-242
    • Schymick, J.C.1    Talbot, K.2    Traynor, B.J.3
  • 61
    • 0014607015 scopus 로고
    • The development of nerve-muscle junctions in monolayer cultures of embryonic spinal cord and skeletal muscle cells
    • Shimada Y, Fischman DA, Moscona AA (1969) The development of nerve-muscle junctions in monolayer cultures of embryonic spinal cord and skeletal muscle cells. J Cell Biol 43, 382-387.
    • (1969) J Cell Biol , vol.43 , pp. 382-387
    • Shimada, Y.1    Fischman, D.A.2    Moscona, A.A.3
  • 62
    • 27744438009 scopus 로고    scopus 로고
    • Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells
    • Singh Roy N, Nakano T, Xuing L, etal. (2005) Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells. Exp Neurol 196, 224-234.
    • (2005) Exp Neurol , vol.196 , pp. 224-234
    • Singh Roy, N.1    Nakano, T.2    Xuing, L.3
  • 63
    • 0343930751 scopus 로고    scopus 로고
    • Schwann cells induce and guide sprouting and reinnervation of neuromuscular junctions
    • Son Y-J, Trachtenburg JT, Thompson WJ (1996) Schwann cells induce and guide sprouting and reinnervation of neuromuscular junctions. Trends Neurosci 19, 280-285.
    • (1996) Trends Neurosci , vol.19 , pp. 280-285
    • Son, Y.-J.1    Trachtenburg, J.T.2    Thompson, W.J.3
  • 64
    • 41149180753 scopus 로고    scopus 로고
    • TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
    • Sreedharan J, Blair IP, Tripathi VB, etal. (2008) TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science 319, 1668-1672.
    • (2008) Science , vol.319 , pp. 1668-1672
    • Sreedharan, J.1    Blair, I.P.2    Tripathi, V.B.3
  • 65
    • 84872635371 scopus 로고
    • A comparison of growth, differentiation, activity and action currents of heart and skeletal muscle in tissue culture
    • Szepsenwol J (1941) A comparison of growth, differentiation, activity and action currents of heart and skeletal muscle in tissue culture. Anat Rec 95, 125-146.
    • (1941) Anat Rec , vol.95 , pp. 125-146
    • Szepsenwol, J.1
  • 66
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, etal. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 67
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Thomson JA, Itskovitz-Eldor J, Shapiro SS, etal. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147.
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1    Itskovitz-Eldor, J.2    Shapiro, S.S.3
  • 68
    • 61349162349 scopus 로고    scopus 로고
    • Mutations in FUS, and RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
    • Vance C, Rogelj B, Hortobagyi T, etal. (2009) Mutations in FUS, and RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 323, 1208-1211.
    • (2009) Science , vol.323 , pp. 1208-1211
    • Vance, C.1    Rogelj, B.2    Hortobagyi, T.3
  • 69
    • 59249098430 scopus 로고    scopus 로고
    • An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction with expressed in neurons of Caenorhabditis elegans
    • Wang J, Farr GW, Hall DH, etal. (2009) An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction with expressed in neurons of Caenorhabditis elegans. PLoS Genet 5, 1-14.
    • (2009) PLoS Genet , vol.5 , pp. 1-14
    • Wang, J.1    Farr, G.W.2    Hall, D.H.3
  • 70
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • Wichterle H, Lieberam I, Porter JA, etal. (2002) Directed differentiation of embryonic stem cells into motor neurons. Cell 110, 385-397.
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3
  • 71
    • 0016810922 scopus 로고
    • Growth of diseased human muscle in combined cultures with normal embryonic mouse spinal cord
    • Witkowski JA, Dubowitz V (1975) Growth of diseased human muscle in combined cultures with normal embryonic mouse spinal cord. J Neurol Sci 26, 20-220.
    • (1975) J Neurol Sci , vol.26 , pp. 20-220
    • Witkowski, J.A.1    Dubowitz, V.2
  • 72
    • 77953530958 scopus 로고    scopus 로고
    • Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice
    • Wong M, Martin LJ (2010) Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice. Hum Mol Genet 19, 2284-2302.
    • (2010) Hum Mol Genet , vol.19 , pp. 2284-2302
    • Wong, M.1    Martin, L.J.2
  • 73
    • 0034794417 scopus 로고    scopus 로고
    • Feeder-free growth of undifferentiated human embryonic stem cells
    • Xu C, Inokuma MS, Denham J, etal. (2001) Feeder-free growth of undifferentiated human embryonic stem cells. Nat Biotechnol 19, 971-974.
    • (2001) Nat Biotechnol , vol.19 , pp. 971-974
    • Xu, C.1    Inokuma, M.S.2    Denham, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.