Novel therapeutic targets for erectile dysfunction

Maturitas

Volumn 71, Issue 1, 2012, Pages 20-27

  Williams, Steve K ^a   Melman, Arnold ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Erectile dysfunction; Novel therapies; Penile erection; Smooth muscle

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; APOCYNIN; APOMORPHINE; AVANAFIL; BMS 193884; BREMELANOTIDE; BROMOCRIPTINE; CYCLIC AMP; CYCLIC GMP; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; LEVODOPA; MELANOCORTIN RECEPTOR; MIRODENAFIL; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; POTASSIUM CHANNEL; PROSTAGLANDIN E1; SILDENAFIL; SILDENAFIL NITRATE; SUPEROXIDE; TADALAFIL; UDENAFIL; UNINDEXED DRUG; VARDENAFIL;

BOTHERSOMENESS; DIABETES MELLITUS; DIZZINESS; DRUG BINDING; DRUG DOSE ESCALATION; DRUG HALF LIFE; DRUG TARGETING; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION; FLUSHING; GENE THERAPY; GENITAL PAIN; HEADACHE; HUMAN; HYPOTHALAMUS; LIBIDO; MALE; METABOLIC CLEARANCE RATE; NAUSEA; PARKINSON DISEASE; PENILE ERYTHEMA; PENIS ERECTION; PHASE 3 CLINICAL TRIAL (TOPIC); REVIEW; SEXUAL DYSFUNCTION; SIDE EFFECT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; VAGINA BLEEDING;

ANIMALS; ERECTILE DYSFUNCTION; GENE THERAPY; HUMANS; IMPOTENCE, VASCULOGENIC; MALE; MELANOCORTINS; PENILE ERECTION; RHO-ASSOCIATED KINASES; TISSUE ENGINEERING;

ANIMALIA;

EID: 84855433033     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2011.11.004     Document Type: Review

References (55)

1. Impotence NIH Consens Statement 10 4 1992 December 7-9 1 33
2. J.B. McKinlay The worldwide prevalence and epidemiology of erectile dysfunction Int J Impot Res 12 Suppl. 4 2000 October S6 S11
3. H.A. Feldman, I. Goldstein, D.G. Hatzichristou, R.J. Krane, and J.B. McKinlay Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study J Urol 151 January (1) 1994 54 61 (Pubitemid 24046934)
4. A. Morelli, S. Filippi, L. Vignozzi, R. Mancina, and M. Maggi Physiology of erectile function: an update on intracellular molecular processes EAU-EBU update series 4 2006 96-97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108
5. K.E. Andersson, and G. Wagner Physiology of penile erection Physiol Rev 75 January (1) 1995 191 236
6. K.E. Andersson Pharmacology of penile erection Pharmacol Rev 53 September (3) 2001 417 450
7. F. Giuliano, and O. Rampin Neural control of erection Physiol Behav 83 2 2004 November 15 189 201 (Pubitemid 39361565)
8. S.H. Francis, I.V. Turko, and J.D. Corbin Cyclic nucleotide phosphodiesterases: relating structure and function Prog Nucleic Acid Res Mol Biol 65 2001 1 52
9. J.D. Corbin, S.H. Francis, and Cyclic GMP phosphodiesterase-5: target of sildenafil J Biol Chem 274 20 1999 May 14 13729 13732
10. R. Mancina, S. Filippi, M. Marini, A. Morelli, L. Vignozzi, and A. Salonia Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens Mol Hum Reprod 11 February (2) 2005 107 115 (Pubitemid 40331291)
11. J.D. Corbin, S.H. Francis, and D.J. Webb Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction Urology 60 2 Suppl. (2) 2002 September 4 11 (Pubitemid 35300142)
12. P. Imming, C. Sinning, and A. Meyer Drugs, their targets and the nature and number of drug targets Nat Rev Drug Discov 5 October (10) 2006 821 834 (Pubitemid 44480536)
13. A.S. Verkman Drug discovery in academia Am J Physiol Cell Physiol 286 March (3) 2004 C465 C474
14. D.K. Montague, J.P. Jarow, G.A. Broderick, R.R. Dmochowski, J.P. Heaton, and T.F. Lue Chapter 1: The management of erectile dysfunction: an AUA update J Urol 174 July (1) 2005 230 239
15. R.C. Rosen, and J.B. Kostis Overview of phosphodiesterase 5 inhibition in erectile dysfunction Am J Cardiol 92 9A 2003 November 6 9M 18M (Pubitemid 37386271)
16. D. Vitezic, and J.M. Pelcic Erectile dysfunction: oral pharmacotherapy options Int J Clin Pharmacol Ther 40 September (9) 2002 393 403 (Pubitemid 34982368)
17. S. Gur, S.C. Sikka, and W.J. Hellstrom Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress Expert Opin Investig Drugs 17 June (6) 2008 855 864 (Pubitemid 351864323)
18. K. Hatzimouratidis, and D.G. Hatzichristou Looking to the future for erectile dysfunction therapies Drugs 68 2 2008 231 250
19. G.J. Christ, D.C. Kim, H.C. Taub, C.M. Gondre, and A. Melman Characterization of nitroglycerine-induced relaxation in human corpus cavernosum smooth muscle: implications to erectile physiology and dysfunction Can J Physiol Pharmacol 73 December (12) 1995 1714 1726 (Pubitemid 26078043)
20. L. De Young, D. Yu, D. Freeman, and G.B. Brock Effect of PDE5 inhibition combined with free oxygen radical scavenger therapy on erectile function in a diabetic animal model Int J Impot Res 15 October (5) 2003 347 354 (Pubitemid 37376940)
21. T. Hayashi, P.A. Juliet, H. Kano-Hayashi, T. Tsunekawa, D. Dingqunfang, and D. Sumi NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction Diabetes Obes Metab 7 July (4) 2005 334 343 (Pubitemid 40916575)
22. J.S. Kalsi, P.D. Kell, S. Cellek, and D.J. Ralph NCX-911, a novel nitric oxide-releasing PDE5 inhibitor relaxes rabbit corpus cavernosum in the absence of endogenous nitric oxide Int J Impot Res 16 April (2) 2004 195 200 (Pubitemid 38579468)
23. N. Shukla, R. Jones, R. Persad, G.D. Angelini, and J.Y. Jeremy Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits Eur J Pharmacol 517 3 2005 July 11 224 231 (Pubitemid 40977899)
24. A. Argiolas, M.R. Melis, S. Murgia, and H.B. Schioth ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptors Brain Res Bull 51 5 2000 March 15 425 431 (Pubitemid 30133216)
25. J. Lindblom, H.B. Schioth, A. Larsson, J.E. Wikberg, and L. Bergstrom Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain Brain Res 810 1-2 1998 November 9 161 171 (Pubitemid 29003402)
26. L.E. Diamond, D.C. Earle, R.C. Rosen, M.S. Willett, and P.B. Molinoff Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction Int J Impot Res 16 February (1) 2004 51 59 (Pubitemid 38401559)
27. F. Holmquist, H.J. Kirkeby, B. Larsson, A. Forman, P. Alm, and K.E. Andersson Functional effects, binding sites and immunolocalization of endothelin-1 in isolated penile tissues from man and rabbit J Pharmacol Exp Ther 261 May (2) 1992 795 802
28. G.J. Christ, S.E. Lerner, D.C. Kim, and A. Melman Endothelin-1 as a putative modulator of erectile dysfunction: I. Characteristics of contraction of isolated corporal tissue strips J Urol 153 June (6) 1995 1998 2003
29. R. Ritchie, and M. Sullivan Endothelins & erectile dysfunction Pharmacol Res 63 June (6) 2011 496 501
30. S.L. Merlin, G.B. Brock, L.R. Begin, F.F. Hiou Tim, A.N. Macramalla, and R.M. Seyam New insights into the role of endothelin-1 in radiation-associated impotence Int J Impot Res 13 April (2) 2001 104 109 (Pubitemid 32506080)
31. N.N. Kim, V. Dhir, K.M. Azadzoi, A.M. Traish, E. Flaherty, and I. Goldstein Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction J Androl 23 January-February (1) 2002 76 83 (Pubitemid 34001132)
32. J.H. Meador-Woodruff Update on dopamine receptors Ann Clin Psychiatry 6 June (2) 1994 79 90 (Pubitemid 24312171)
33. E. Dula, S. Bukofzer, R. Perdok, M. George Apomorphine SL Study Group Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction Eur Urol 39 May (5) 2001 558 563 discussion 564
34. H. Padma-Nathan, C. Steidle, S. Salem, N. Tayse, J. Yeager, and R. Harning The efficacy and safety of a topical alprostadil cream, Alprox-TD, for the treatment of erectile dysfunction: two phase 2 studies in mild-to-moderate and severe ED Int J Impot Res 15 February (1) 2003 10 17 (Pubitemid 36356353)
35. I.A. Abdel-Hamid, K.E. Andersson, and A. Salonia Exploration of therapeutic targets for sexual dysfunctions: lessons learned from the failed stories Expert Opin Ther Targets 15 March (3) 2011 325 340
36. M. Cowart, S.P. Latshaw, P. Bhatia, J.F. Daanen, J. Rohde, and S.L. Nelson Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction J Med Chem 47 15 2004 July 15 3853 3864 (Pubitemid 38900350)
37. M.R. Melis, S. Succu, F. Sanna, T. Melis, M.S. Mascia, and C. Enguehard-Gueiffier PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain Eur J Neurosci 24 October (7) 2006 2021 2030 (Pubitemid 44583486)
38. I. Goldstein, T.R. Payton, and P.J. Schechter A double-blind, placebo-controlled, efficacy and safety study of topical gel formulation of 1% alprostadil (Topiglan) for the in-office treatment of erectile dysfunction Urology 57 February (2) 2001 301 305 (Pubitemid 32140808)
39. N.F. Gonzalez-Cadavid, and J. Rajfer Therapy of erectile dysfunction: potential future treatments Endocrine 23 March-April (2-3) 2004 167 176 (Pubitemid 39140230)
40. D. Schultheiss Regenerative medicine in andrology: tissue engineering and gene therapy as potential treatment options for penile deformations and erectile dysfunction Eur Urol 46 August (2) 2004 162 169 (Pubitemid 38902730)
41. G. Schenk, A. Melman, and G. Christ Gene therapy: future therapy for erectile dysfunction Curr Urol Rep 2 December (6) 2001 480 487
42. M. Kendirci, P.E. Teloken, H.C. Champion, W.J. Hellstrom, and T.J. Bivalacqua Gene therapy for erectile dysfunction: fact or fiction? Eur Urol 50 December (6) 2006 1208 1222 (Pubitemid 44692938)
43. S. Tirney, C.E. Mattes, N. Yoshimura, T. Yokayama, H. Ozawa, and E. Tzeng Nitric oxide synthase gene therapy for erectile dysfunction: comparison of plasmid, adenovirus, and adenovirus-transduced myoblast vectors Mol Urol 5 Spring (1) 2001 37 43 (Pubitemid 32242556)
44. T.R. Magee, M. Ferrini, H.J. Garban, D. Vernet, K. Mitani, and J. Rajfer Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase Biol Reprod 67 July (1) 2002 20 28 (Pubitemid 34680631)
45. G.J. Christ Frontiers in gene therapy for erectile dysfunction Int J Impot Res 15 Suppl. (5) 2003 October S33 S40
46. R.S. Rogers, T.M. Graziottin, C.S. Lin, Y.W. Kan, and T.F. Lue Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats Int J Impot Res 15 February (1) 2003 26 37 (Pubitemid 36356356)
47. N.F. Gonzalez-Cadavid, and J. Rajfer Molecular pathophysiology and gene therapy of aging-related erectile dysfunction Exp Gerontol 39 November-December (11-12) 2004 1705 1712 (Pubitemid 39576140)
48. A.A. Shokeir, A.M. Harraz, and A.B. El-Din Tissue engineering and stem cells: basic principles and applications in urology Int J Urol 17 December (12) 2010 964 973
49. P.S. Hsieh, D.J. Bochinski, G.T. Lin, L. Nunes, C.S. Lin, and T.F. Lue The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model BJU Int 92 September (4) 2003 470 475 (Pubitemid 37100532)
50. F. May, N. Weidner, K. Matiasek, C. Caspers, T. Mrva, and M. Vroemen Schwann cell seeded guidance tubes restore erectile function after ablation of cavernous nerves in rats J Urol 172 July (1) 2004 374 377
51. R.T. Kershen, J.J. Yoo, R.B. Moreland, R.J. Krane, and A. Atala Reconstitution of human corpus cavernosum smooth muscle in vitro and in vivo Tissue Eng 8 July (3) 2002 515 524 (Pubitemid 34747806)
52. H.J. Park, J.J. Yoo, R.T. Kershen, R. Moreland, and A. Atala Reconstitution of human corporal smooth muscle and endothelial cells in vivo J Urol 162 3 Pt (2) 1999 September 1106 1109 (Pubitemid 29434681)
53. H. Wessells, and S.K. Williams Endothelial cell transplantation into the corpus cavernosum: moving towards cell-based gene therapy J Urol 162 December (6) 1999 2162 2164
54. J.J. Yoo, I. Lee, and A. Atala Cartilage rods as a potential material for penile reconstruction J Urol 160 3 Pt (2) 1998 September 1164 1168 discussion 1178 (Pubitemid 29477771)
55. B.S. Kim, J.J. Yoo, and A. Atala Engineering of human cartilage rods: potential application for penile prostheses J Urol 168 4 Pt (2) 2002 October 1794 1797 (Pubitemid 35034088)