Endothelins & erectile dysfunction

Pharmacological Research

Volumn 63, Issue 6, 2011, Pages 496-501

  Ritchie, Robert ^a,b   Sullivan, Mark ^a,b  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Diabetes; Endothelin antagonist; Endothelins; Erectile Dysfunction; Erection

Indexed keywords

BMS 193884; CALCIUM ION; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; PLACEBO; TADALAFIL;

BINDING SITE; CALCIUM TRANSPORT; DRUG EFFICACY; DRUG MECHANISM; ERECTILE DYSFUNCTION; HUMAN; NERVE TRACT; NONHUMAN; PATHOGENESIS; PENIS ERECTION; PINEAL BODY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REVIEW; UPREGULATION;

ADULT; AGED; ENDOTHELINS; ERECTILE DYSFUNCTION; HUMANS; MALE; MIDDLE AGED; PENILE ERECTION; PENIS; RECEPTORS, ENDOTHELIN;

EID: 79958038502     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.12.006     Document Type: Review

References (53)

1. NIH consensus conference. Impotence. NIH consensus development panel on impotence. JAMA 1993;270:83-90.
2. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol 1994;151:54-61. (Pubitemid 24046934)
3. Corona G, Lee DM, Forti G, O'Connor DB, Maggi M, O'Neill TW, et al. Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS). J Sex Med 2010;7:1362-80.
4. Ayta IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999;84:50-6.
5. Gratzke C, Angulo J, Chitaley K, Dai YT, Kim NN, Paick JS, et al. Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med 2010;7:445-75.
6. Andersson KE, Wagner G. Physiology of penile erection. Physiol Rev 1995;75:191-236.
7. Benassi-Benelli A, Ferrari F, Quarantotti BP. Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats. Arch Int Pharmacodyn Ther 1979;242:241-7. (Pubitemid 10132594)
8. Melis MR, Spano MS, Succu S, Argiolas A. The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male rats. Neurosci Lett 1999;265:171-4. (Pubitemid 29207393)
9. Argiolas A, Melis MR, Murgia S, Schioth HB. ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptors. Brain Res Bull 2000;51:425-31. (Pubitemid 30133216)
10. Sato Y, Horita H, Kurohata T, Adachi H, Tsukamoto T. Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats. Am J Physiol 1998;274:R243-7.
11. Sato Y, Christ GJ, Horita H, Adachi H, Suzuki N, Tsukamoto T. The effects of alterations in nitric oxide levels in the paraventricular nucleus on copulatory behavior and reflexive erections in male rats. J Urol 1999;162:2182-5.
12. Yonezawa A, Watanabe C, Ando R, Furuta S, Sakurada S, Yoshimura H, et al. Characterization of P-chloroamphetamine-induced penile erection and ejaculation in anesthetized rats. Life Sci 2000;67:3031-9.
13. Rosaria Melis M, Spano MS, Succu S, Argiolas A. Activation of gamma-aminobutyric acid(A) receptors in the paraventricular nucleus of the hypothalamus reduces apomorphine-N-methyl-D-aspartic acid- and oxytocin-induced penile erection and yawning in male rats. Neurosci Lett 2000;281:127-30. (Pubitemid 30125881)
14. Ferrari F, Ottani A, Giuliani D. Inhibitory effects of the cannabinoid agonist HU 210 on rat sexual behaviour. Physiol Behav 2000;69:547-54. (Pubitemid 30460094)
15. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-5. (Pubitemid 18090241)
16. Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T, Goto K, et al. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A 1989;86:2863-7. (Pubitemid 19112640)
17. Auguet M, Delaflotte S, Guillon JM, Chabrier PE, Braquet P. Different regulation of vascular tone by angiotensin II and endothelin-1 in rat aorta. Eur J Pharmacol 1991;196:21-7.
18. Christ GJ, Lerner SE, Kim DC, Melman A. Endothelin-1 as a putative modulator of erectile dysfunction. I. Characteristics of contraction of isolated corporal tissue strips. J Urol 1995;153:1998-2003.
19. Zhao W, Christ GJ. Endothelin-1 as a putative modulator of erectile dysfunction. II. Calcium mobilization in cultured human corporal smooth muscle cells. J Urol 1995;154:1571-9.
20. de Tejada IS, Carson MP, de las Morenas A, Goldstein I, Traish AM. Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum. Am J Physiol 1991;261:H1078-85.
21. Holmquist F, Kirkeby HJ, Larsson B, Forman A, Alm P, Andersson KE. Functional effects, binding sites and immunolocalization of endothelin-1 in isolated penile tissues from man and rabbit. J Pharmacol Exp Ther 1992;261:795-802.
22. Nakamura S, Naruse M, Naruse K, Demura H, Uemura H. Immunocytochemical localization of endothelin in cultured bovine endothelial cells. Histochemistry 1990;94:475-7. (Pubitemid 20303240)
23. Holmquist F, Andersson KE, Hedlund H. Actions of endothelin on isolated corpus cavernosum from rabbit and man. Acta Physiol Scand 1990;139:113-22. (Pubitemid 20161198)
24. Somlyo AP, Somlyo AV. Signal transduction by g-proteins. Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000;522(Pt 2):177-85. (Pubitemid 30068498)
25. Somlyo AP, Somlyo AV. Signal transduction and regulation in smooth muscle. Nature 1994;372:231-6. (Pubitemid 24352442)
26. Fujihara H, Walker LA, Gong MC, Lemichez E, Boquet P, Somlyo AV, et al. Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin dc3b. Mol Biol Cell 1997;8:2437-47. (Pubitemid 27528212)
27. 2+ sensitization in erectile function. J Biol Chem 2002;277:30614-21.
28. Wingard CJ, Husain S, Williams J, James S. RhoA-Rho Kinase mediates synergistic ET-1 and phenylephrine contraction of rat corpus cavernosum. Am J Physiol Regul Integr Comp Physiol 2003;285:R1145-52.
29. Myung SC, Lee MY, Lee SY, Yum SH, Park SH, Kim SC. Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder. J Sex Med 2008;5:1088-96.
30. Allahdadi KJ, Hannan JL, Tostes RC, Webb RC. Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and rho-kinase activation. J Sex Med 2010;7:2096-103.
31. Takahashi K, Ghatei MA, Lam HC, O'Halloran DJ, Bloom SR. Elevated plasma endothelin in patients with diabetes mellitus. Diabetologia 1990;33:306-10. (Pubitemid 20161886)
32. Francavilla S, Properzi G, Bellini C, Marino G, Ferri C, Santucci A. Endothelin-1 in diabetic and nondiabetic men with erectile dysfunction. J Urol 1997;158:1770-4. (Pubitemid 27433149)
33. Bell CR, Sullivan ME, Dashwood MR, Muddle JR, Morgan RJ. The density and distribution of endothelin 1 and endothelin receptor subtypes in normal and diabetic rat corpus cavernosum. Br J Urol 1995;76:203-7.
34. Sullivan ME, Dashwood MR, Thompson CS, Muddle JR, Mikhailidis DP, Morgan RJ. Alterations in endothelin b receptor sites in cavernosal tissue of diabetic rabbits: potential relevance to the pathogenesis of erectile dysfunction. J Urol 1997;158:1966-72. (Pubitemid 27433196)
35. Sullivan ME. Investigations into the pathogenesis of diabetic erectile dysfunction. University of London; 1998.
36. Sullivan ME, Shukla N, Thompson CS, Dashwood MR, Mikhailidis DP, Morgan RJ. Endothelin receptor antagonists inhibit diabetic rabbit cavernosal smooth muscle cell proliferation. Br J Urol 1997;79(Suppl. 4):55. (Pubitemid 127748809)
37. Giraldi A, Serels S, Autieri M, Melman A, Christ GJ. Endothelin-1 as a putative modulator of gene expression and cellular physiology in cultured human corporal smooth muscle cells. J Urol 1998;160:1856-62. (Pubitemid 128746775)
38. Sullivan ME, Dashwood MR, Thompson CS, Mikhailidis DP, Morgan RJ. Down-regulation of endothelin-B receptor sites in cavernosal tissue of hypercholesterolaemic rabbits. Br J Urol 1998;81:128-34. (Pubitemid 28316510)
39. Arendt RM, Wilbert-Lampen U, Heucke L, Schmoeckel M, Suhler K, Richter WO. Increased endothelin plasma concentrations in patients with coronary artery disease or hyperlipoproteinemia without coronary events. Res Exp Med (Berl) 1993;193:225-30. (Pubitemid 23253258)
40. Becker AJ, Uckert S, Stief CG, Truss MC, Hartmann U, Jonas U. Systemic and cavernosal plasma levels of endothelin (1-21) during different penile conditions in healthy males and patients with erectile dysfunction. World J Urol 2001;19:371-6.
41. Chang S, Hypolite JA, Changolkar A, Wein AJ, Chacko S, DiSanto ME. Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via rho-kinase beta. Int J Impot Res 2003;15:53-62. (Pubitemid 36356359)
42. Dai Y, Pollock DM, Lewis RL, Wingard CJ, Stopper VS, Mills TM. Receptor-specific influence of endothelin-1 in the erectile response of the rat. Am J Physiol Regul Integr Comp Physiol 2000;279:R25-30.
43. Merlin SL, Brock GB, Begin LR, Tim FFH, Macramalla AN, Seyam RM, et al. New insights into the role of endothelin-1 in radiation-associated impotence. Int J Impot Res 2001;13:104-9. (Pubitemid 32506080)
44. Alici B, Gumustas MK, Ozkara H, Akkus E, Demirel G, Yencilek F, et al. Apoptosis in the erectile tissues of diabetic and healthy rats. BJU Int 2000;85:326-9. (Pubitemid 30088529)
45. Klein LT, Miller MI, Buttyan R, Raffo AJ, Burchard M, Devris G, et al. Apoptosis in the rat penis after penile denervation. J Urol 1997;158:626-30. (Pubitemid 27327736)
46. Jesmin S, Zaedi S, Yamaguchi N, Maeda S, Yamaguchi I, Goto K, et al. Effects of dual endothelin receptor antagonist on antiapoptotic marker bcl-2 expression in streptozotocin-induced diabetic rats. Exp Biol Med (Maywood) 2006;231:1034-9. (Pubitemid 43845573)
47. Kim NN, Dhir V, Azadzoi KM, Traish AM, Flaherty E, Goldstein I. Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction. J Androl 2002;23:76-83. (Pubitemid 34001132)
48. Kalani M, Pernow J, Bragd J, Jorneskog G. Improved peripheral perfusion during endothelin - a receptor blockade in patients with Type 2 diabetes and critical limb ischemia. Diabetes Care 2008;31:e56.
49. Mather KJ, Mirzamohammadi B, Lteif A, Steinberg HO, Baron AD. Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and Type 2 diabetes. Diabetes 2002;51:3517-23. (Pubitemid 35403459)
50. Settergren M, Pernow J, Brismar K, Jorneskog G, Kalani M. Endothelin-A receptor blockade increases nutritive skin capillary circulation in patients with type 2 diabetes and microangiopathy. J Vasc Res 2008;45:295-302. (Pubitemid 351793732)
51. Khan ZA, Chakrabarti S. Endothelins in chronic diabetic complications. Can J Physiol Pharmacol 2003;81:622-34. (Pubitemid 36836396)
52. Carneiro FS, Nunes KP, Giachini FRC, Lima VV, Carneiro ZN, Nogueira EF, et al. Activation of the ET-1/ETA pathway contributes to erectile dysfunction associated with mineralocorticoid hypertension. J Sex Med 2008;5:2793-807.
53. Proietti M, Aversa A, Letizia C, Rossi C, Menghi G, Bruzziches R, et al. Erectile dysfunction in systemic sclerosis: effects of longterm inhibition of phosphodiesterase type-5 on erectile function and plasma endothelin-1 levels. J Rheumatol 2007;34:1712-7. (Pubitemid 47267615)