Vitis vinifera L. grape skin extract activates the insulin-signalling cascade and reduces hyperglycaemia in alloxan-induced diabetic mice

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 2, 2012, Pages 268-276

  Soares De Moura, R ^a   Da Costa, Giselle França ^a   Moreira, Annie Seixas Bello ^a   Queiroz, Emerson Ferreira ^b   Moreira, Daniele Dal Col ^b   Garcia Souza, Erica Patrícia ^a   Resende, Ângela Castro ^a   Moura, Aníbal Sanchez ^a   Teixeira, Michelle Teixeira ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Department of Research Development and Innovation   (Brazil)

Author keywords

diabetic mice; grape skin extract; hyperglycaemia; insulin cascade; insulin resistance

Indexed keywords

ACH 09; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; PROTEIN KINASE B; UNCLASSIFIED DRUG; VITIS VINIFERA EXTRACT;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; GASTROCNEMIUS MUSCLE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN LIKE ACTIVITY; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ALLOXAN; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICE; MUSCLE, SKELETAL; PLANT EXTRACTS; RECEPTOR, INSULIN; VITIS;

EID: 84855430483     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01395.x     Document Type: Article

References (38)

1. International Diabetes Federation. Diabetes Atlas, 2nd edn. Brussels: Delice Gan, 2003.
2. Zunino S,. Type 2 diabetes and glycemic response to grapes or grape products. J Nutr 2009; 139: 1794S-1800S.
3. Renaud S, de Lorgeril M,. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 20: 1523-1526.
4. St Leger AS, et al,. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1979; 12: 1017-1020.
5. Saleem TS, Basha SDJ,. Red wine: a drink to your heart. Cardiovasc Dis Res 2010; 1: 171-176.
6. Lippi G, et al,. Moderate red wine consumption and cardiovascular disease risk: beyond the 'French paradox'. Semin Thromb Hemost 2010; 36: 59-70.
7. Demrow HS, et al,. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 1995; 15: 1182-1188.
8. Soares de Moura R, et al,. Antihypertensive, vasodilator and antioxidant effects of a vinifera grape skin extract. J Pharm Pharmacol 2002; 54: 1515-1520. (Pubitemid 35331213)
9. Frankel EN, et al,. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 1993; 20: 454-457. (Pubitemid 23054518)
10. Fitzpatrick DF, et al,. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 1993; 265: 774-778.
11. Wallerath T, et al,. Red wine increases the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects. J Am Coll Cardiol 2003; 05: 471-478. (Pubitemid 36164505)
12. Hodge AM, et al,. Alcohol intake, consumption pattern and beverage type, and the risk of Type 2 diabetes. Diabet Med 2006; 23: 690-697. (Pubitemid 43830073)
13. Marfella R, et al,. Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus. Diabet Med 2006; 23: 974-981. (Pubitemid 44257941)
14. Ceriello A, et al,. Red wine protects diabetic patients from meal-induced oxidative stress and thrombosis activation: a pleasant approach to the prevention of cardiovascular disease in diabetes. Eur J Clin Invest 2001; 31: 322-328. (Pubitemid 32328533)
15. Napoli R, et al,. Red wine consumption improves insulin resistance but not endothelial function in type 2 diabetic patients. Metabolism 2005; 54: 306-313. (Pubitemid 40250090)
16. Wei M, et al,. Alcohol intake and incidence of type 2 diabetes in men. Diabetes Care 2000; 23: 18-22.
17. Cherniack EP,. Polyphenols: planting the seeds of treatment for the metabolic syndrome. Nutrition 2011; 27: 617-623.
18. Orhan N, et al,. In-vivo assessment of antidiabetic and antioxidant activities of grapevine leaves (Vitis vinifera) in diabetic rats. J Ethnopharmacol 2006; 108: 280-286. (Pubitemid 44635033)
19. de Moura RS, et al,. Protective action of a hydroalcoholic extract of a vinifera grape skin on experimental preeclampsia in rats. Hypertens Pregnancy 2007; 26: 89-100. (Pubitemid 46649349)
20. Singleton VL, et al,. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 1999; 299: 152-178. (Pubitemid 28483890)
21. Bruins AP, et al,. Ion spray interface for combined liquid chromatography/atmospheric pressure ionization mass-spectrometry. Anal Chem 1987; 59: 2642-2646.
22. Bayne K,. Revised guide for the care and use of laboratory animals available. American Physiological Society. Physiologist 1996; 39: 208-211.
23. Matthews DR, et al,. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419. (Pubitemid 15018832)
24. Beneytez EG, et al,. Analysis of grape and wine anthocyanins by HPLC-MS. J Agric Food Chem 2003; 51: 5622-5629.
25. Wang H, et al,. Characterisation of anthocyanins in grape juices by ion trap liquid chromatography-mass spectrometry. J Agric Food Chem 2003; 51: 1839-1844.
26. Dohadwala MM, Vita JA,. Grapes and cardiovascular disease. J Nutr 2009; 139: 1788S-1793S.
27. Szmitko PE, Verma S,. Cardiology patient pages. Red wine and your heart. Circulation 2005; 18: 10-11.
28. Al-Awwadi NA, et al,. Red wine polyphenols alone or in association with ethanol prevent hypertension, cardiac hypertrophy, and production of reactive oxygen species in the insulin-resistant fructose-fed rat. J Agric Food Chem 2004; 08: 5593-5597.
29. Pinent M, et al,. Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology 2004; 145: 4985-4990. (Pubitemid 39551116)
30. Boylan JM, et al,. Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats. J Clin Invest 1992; 90: 174-179.
31. Saltiel AR, Kahn CR,. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001; 13: 799-806. (Pubitemid 34000783)
32. Kar P, et al,. Effects of grape seed extract in type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med 2009; 26: 526-531.
33. Sivaprakasapillai B, et al,. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism 2009; 58: 1743-1746.
34. Roy D, et al,. Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is NO dependent. Am J Physiol 1998; 274: E692-E699.
35. Erlich Y, Rosenthal T,. Chronic hypertension leads to hyperinsulinemia in Sprague-Dawley rats treated with nitric oxide synthase inhibitor. Am J Hypertens 1998; 11: 1129-1133. (Pubitemid 28456085)
36. Balon TW, Nadler JL,. Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol 1997; 82: 359-363. (Pubitemid 27052084)
37. Lira VA, et al,. Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle. Am J Physiol Endocrinol Metab 2007; 293: E1062-E1068. (Pubitemid 47535838)
38. Cheng AY, Fantus IG,. Oral antihyperglycemic therapy for type 2 diabetes mellitus. CMAJ 2005; 18: 213-226.