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Volumn 151, Issue 4, 2010, Pages 1822-1828

Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: Role of phosphatidylinositol 3-kinase/Akt pathway

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDRALLOSTANE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B BETA; SMALL INTERFERING RNA; TESTOSTERONE;

EID: 77950286070     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-1048     Document Type: Article
Times cited : (108)

References (36)
  • 1
    • 0032190474 scopus 로고    scopus 로고
    • Cardiovascular steroid actions: Swift swallows or sluggish snails?
    • Christ M, Wehling M 1998 Cardiovascular steroid actions: swift swallows or sluggish snails? Cardiovasc Res 40:34-44
    • (1998) Cardiovasc Res , vol.40 , pp. 34-44
    • Christ, M.1    Wehling, M.2
  • 2
    • 70349859846 scopus 로고    scopus 로고
    • Gender differences in the cardiovascular effect of sex hormones
    • Vitale C, Mendelsohn ME, Rosano GM 2009 Gender differences in the cardiovascular effect of sex hormones. Nat Rev Cardiol 6:532-542
    • (2009) Nat Rev Cardiol , vol.6 , pp. 532-542
    • Vitale, C.1    Mendelsohn, M.E.2    Rosano, G.M.3
  • 3
    • 37349118353 scopus 로고    scopus 로고
    • Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study
    • Khaw KT, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, Welch A, Day N 2007 Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation 116:2694-2701
    • (2007) Circulation , vol.116 , pp. 2694-2701
    • Khaw, K.T.1    Dowsett, M.2    Folkerd, E.3    Bingham, S.4    Wareham, N.5    Luben, R.6    Welch, A.7    Day, N.8
  • 5
  • 6
    • 0033081492 scopus 로고    scopus 로고
    • Effect of acute testosterone on myocardial ischemia in men with coronary artery disease
    • A9
    • Webb CM, Adamson DL, de Zeigler D, Collins P 1999 Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. Am J Cardiol 83:437-439, A9
    • (1999) Am J Cardiol , vol.83 , pp. 437-439
    • Webb, C.M.1    Adamson, D.L.2    De Zeigler, D.3    Collins, P.4
  • 8
    • 0034680343 scopus 로고    scopus 로고
    • Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study
    • English KM, Steeds RP, Jones TH, Diver MJ, Channer KS 2000 Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation 102:1906-1911
    • (2000) Circulation , vol.102 , pp. 1906-1911
    • English, K.M.1    Steeds, R.P.2    Jones, T.H.3    Diver, M.J.4    Channer, K.S.5
  • 9
    • 0033979926 scopus 로고    scopus 로고
    • Testosterone enhances flow-mediated brachial artery reactivity in men with coronary artery disease
    • Ong PJ, Patrizi G, Chong WC, Webb CM, Hayward CS, Collins P 2000 Testosterone enhances flow-mediated brachial artery reactivity in men with coronary artery disease. Am J Cardiol 85:269-272
    • (2000) Am J Cardiol , vol.85 , pp. 269-272
    • Ong, P.J.1    Patrizi, G.2    Chong, W.C.3    Webb, C.M.4    Hayward, C.S.5    Collins, P.6
  • 10
    • 0036532488 scopus 로고    scopus 로고
    • Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease
    • Kang SM, Jang Y, Kim JY, Chung N, Cho SY, Chae JS, Lee JH 2002 Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease. Am J Cardiol 89:862-864
    • (2002) Am J Cardiol , vol.89 , pp. 862-864
    • Kang, S.M.1    Jang, Y.2    Kim, J.Y.3    Chung, N.4    Cho, S.Y.5    Chae, J.S.6    Lee, J.H.7
  • 13
    • 0033584717 scopus 로고    scopus 로고
    • Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease
    • Webb CM, McNeill JG, Hayward CS, de Zeigler D, Collins P 1999 Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 100:1690-1696
    • (1999) Circulation , vol.100 , pp. 1690-1696
    • Webb, C.M.1    McNeill, J.G.2    Hayward, C.S.3    De Zeigler, D.4    Collins, P.5
  • 16
    • 0033432774 scopus 로고    scopus 로고
    • Different mechanisms for testosterone-induced relaxation of aorta between normotensive and spontaneously hypertensive rats
    • Honda H, Unemoto T, Kogo H 1999 Different mechanisms for testosterone-induced relaxation of aorta between normotensive and spontaneously hypertensive rats. Hypertension 34:1232-1236
    • (1999) Hypertension , vol.34 , pp. 1232-1236
    • Honda, H.1    Unemoto, T.2    Kogo, H.3
  • 17
    • 0036177557 scopus 로고    scopus 로고
    • Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels
    • Tep-areenan P, Kendall DA, Randall MD 2002 Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels. Br J Pharmacol 135:735-740
    • (2002) Br J Pharmacol , vol.135 , pp. 735-740
    • Tep-areenan, P.1    Kendall, D.A.2    Randall, M.D.3
  • 19
    • 33845982523 scopus 로고    scopus 로고
    • Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: A possible involvement of androgen receptor
    • Yu J, Eto M, Akishita M, Kaneko A, Ouchi Y, Okabe T 2007 Signaling pathway of nitric oxide production induced by ginsenoside Rb1 in human aortic endothelial cells: a possible involvement of androgen receptor. Biochem Biophys Res Commun 353:764-769
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 764-769
    • Yu, J.1    Eto, M.2    Akishita, M.3    Kaneko, A.4    Ouchi, Y.5    Okabe, T.6
  • 20
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM 1999 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 22
    • 0028095620 scopus 로고
    • Structure, regulation and function of phosphoinositide 3-kinases
    • Fry MJ 1994 Structure, regulation and function of phosphoinositide 3-kinases. Biochim Biophys Acta 1226:237-268
    • (1994) Biochim Biophys Acta , vol.1226 , pp. 237-268
    • Fry, M.J.1
  • 24
    • 0034727094 scopus 로고    scopus 로고
    • Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
    • Simoncini T, Hafezi-Moghadam A, Brazil DP, Ley K, Chin WW, Liao JK 2000 Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 407:538-541
    • (2000) Nature , vol.407 , pp. 538-541
    • Simoncini, T.1    Hafezi-Moghadam, A.2    Brazil, D.P.3    Ley, K.4    Chin, W.W.5    Liao, J.K.6
  • 26
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • Moncada S, Higgs A 1993 The L-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 27
    • 0033569924 scopus 로고    scopus 로고
    • Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
    • Gallis B, Corthals GL, Goodlett DR, Ueba H, Kim F, Presnell SR, Figeys D, Harrison DG, Berk BC, Aebersold R, Corson MA 1999 Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002. J Biol Chem 274:30101-30108
    • (1999) J Biol Chem , vol.274 , pp. 30101-30108
    • Gallis, B.1    Corthals, G.L.2    Goodlett, D.R.3    Ueba, H.4    Kim, F.5    Presnell, S.R.6    Figeys, D.7    Harrison, D.G.8    Berk, B.C.9    Aebersold, R.10    Corson, M.A.11
  • 28
    • 33745080255 scopus 로고    scopus 로고
    • Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization
    • Boo YC, Kim HJ, Song H, Fulton D, Sessa W, Jo H 2006 Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization. Free Radic Biol Med 41:144-153
    • (2006) Free Radic Biol Med , vol.41 , pp. 144-153
    • Boo, Y.C.1    Kim, H.J.2    Song, H.3    Fulton, D.4    Sessa, W.5    Jo, H.6
  • 29
    • 33846392950 scopus 로고    scopus 로고
    • Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
    • Mount PF,Kemp BE, Power DA 2007 Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol 42:271-279
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 271-279
    • Mount, P.F.1    Kemp, B.E.2    Power, D.A.3
  • 34
    • 0242290354 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85α, androgen receptor, and Src
    • Sun M, Yang L, Feldman RI, Sun XM, Bhalla KN, Jove R, Nicosia SV, Cheng JQ 2003 Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85α, androgen receptor, and Src. J Biol Chem 278:42992-43000
    • (2003) J Biol Chem , vol.278 , pp. 42992-43000
    • Sun, M.1    Yang, L.2    Feldman, R.I.3    Sun, X.M.4    Bhalla, K.N.5    Jove, R.6    Nicosia, S.V.7    Cheng, J.Q.8
  • 35
    • 0342723183 scopus 로고    scopus 로고
    • Role of endothelium in the vasodilating effect of progestins and androgens on the rat thoracic aorta
    • Perusquía M, Hernández R, Morales MA, Campos MG, Villalón CM 1996 Role of endothelium in the vasodilating effect of progestins and androgens on the rat thoracic aorta. Gen Pharmacol 27:181-185
    • (1996) Gen Pharmacol , vol.27 , pp. 181-185
    • Perusquía, M.1    Hernández, R.2    Morales, M.A.3    Campos, M.G.4    Villalón, C.M.5
  • 36
    • 0001297516 scopus 로고
    • Treatment of angina pectoris by testosterone propionate
    • Sigler LH, Tulgan J 1943 Treatment of angina pectoris by testosterone propionate. NY State J Med 43:1424-1428
    • (1943) NY State J Med , vol.43 , pp. 1424-1428
    • Sigler, L.H.1    Tulgan, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.