Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster

FASEB Journal

Volumn 26, Issue 1, 2012, Pages 192-202

  Kumita, Janet R ^a   Helmfors, Linda ^b   Williams, Jocy ^a   Luheshi, Leila M ^a   Menzer, Linda ^c   Dumoulin, Mireille ^c   Lomas, David A ^d   Crowther, Damian C ^a,d   Dobson, Christopher M ^a   Brorsson, Ann Christin ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b LINKÖPING UNIVERSITY   (Sweden)

^c UNIVERSITY OF LIÈGE   (Belgium)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

ER stress; Quality control system; xbp1 EGFP

Indexed keywords

LYSOZYME; TRANSCRIPTION FACTOR GAL4;

ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE DEVELOPMENT; FAMILIAL AMYLOIDOSIS; HEMOLYMPH; HUMAN; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN VARIANT; SCANNING ELECTRON MICROSCOPY; UBIQUITINATION; UNFOLDED PROTEIN RESPONSE; WILD TYPE;

AMYLOIDOSIS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOPLASMIC RETICULUM STRESS; EYE ABNORMALITIES; FEMALE; GREEN FLUORESCENT PROTEINS; HEMOLYMPH; HUMANS; MALE; METAMORPHOSIS, BIOLOGICAL; MICROSCOPY, ELECTRON, SCANNING; MURAMIDASE; PHOTORECEPTOR CELLS, INVERTEBRATE; SOLUBILITY; UNFOLDED PROTEIN RESPONSE;

DROSOPHILA MELANOGASTER;

EID: 84855393385     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-185983     Document Type: Article

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