Keratinocyte-targeted overexpression of the glucocorticoid receptor delays cutaneous wound healing

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Sanchis, Ana ^a   Alba, Lorena ^a   Latorre, Víctor ^a   Sevilla, Lisa M ^a   Pérez, Paloma ^a  

^a CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; COLLAGEN; CYCLIN D1; CYTOKERATIN 10; CYTOKERATIN 6; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 1BETA; KERATINOCYTE GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN C FOS; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CELL CULTURE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EPITHELIZATION; FEMALE; GENE; GENE OVEREXPRESSION; GENE REPRESSION; GENE TARGETING; GRANULATION TISSUE; GRANULOCYTE; IN VITRO STUDY; IN VIVO STUDY; INTERLEUKIN 1BETA GENE; KERATINOCYTE; KERATINOCYTE GROWTH FACTOR GENE; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REEPITHELIZATION; TRANSFORMING GROWTH FACTOR BETA1 GENE; TRANSFORMING GROWTH FACTOR BETA3 GENE; TRANSGENIC MOUSE; TRANSREPRESSION; TUMOR NECROSIS FACTOR ALPHA GENE; UPREGULATION; WOUND HEALING IMPAIRMENT; WOUND SCRATCH ASSAY; ANIMAL; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; INJURY; METABOLISM; MUTATION; PATHOPHYSIOLOGY; SKIN; TRANSCRIPTION INITIATION; WOUND HEALING;

MUS; MUS MUSCULUS;

ANIMALS; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; RECEPTORS, GLUCOCORTICOID; SKIN; TRANSCRIPTIONAL ACTIVATION; WOUND HEALING;

EID: 84855374132     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029701     Document Type: Article

References (36)

1. De Bosscher K, Haegeman G, (2009) Minireview: Latest Perspectives on Antiinflammatory Actions of glucocorticoids. Mol Endocrinol 23: 281-291.
2. Schäcke H, Döcke WD, Asadullah K, (2002) Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 96: 23-43.
3. Barnes PJ, Adcock IM, (2009) Glucocorticoid resistance in inflammatory diseases. Lancet 373: 1905-1917.
4. Revollo JR, Cidlowski JA, (2009) Mechanisms Generating Diversity in glucocorticoid Receptor Signaling. Ann NY Acad Sci 1179: 167-178.
5. Stanisić V, Lonard DM, O'Malley BW, (2010) Modulation of steroid hormone receptor activity. Prog Brain Res 181: 153-176.
6. So A, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR, (2008) Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes. Proc Natl Acad Sci USA 105: 5745-5749.
7. Kassel O, Herrlich P, (2007) Cross-talk between the glucocorticoid receptor and other transcription factors:molecular aspects. Mol Cell Endocrinol 275: 13-29.
8. Davies L, Karthikeyan N, Lynch JT, Sial E, Gkourtsa A, Demonacos C, Krstic-Demonacos M, (2009) Cross Talk of Signaling Pathways in the Regulation of the glucocorticoid Receptor Function. Mol Endocrinol 22: 1331-1344.
9. Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, et al. (1998) DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93: 531-541.
10. Cole TJ, Blendy AP, Monaghan K, Schmid W, Aguzzi A, et al. (1995) Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev 9: 1608-1621.
11. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, et al. (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23: 99-103.
12. Helmberg A, Auphan N, Caelles C, Karin M, (1995) Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J 14 (3): 452-460.
13. Clark A, (2007) Anti-inflammatory functions of glucocorticoid-induced genes. Mol Cell Endocrinol 275: 79-97.
14. Tuckermann JP, Kleiman A, Moriggl R, Spanbroek R, Neumann A, et al. (2007) Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest 117: 1381-1390.
15. Werner S, Grose R, (2003) Regulation of Wound Healing by Growth Factors and Cytokines. Physiol Rev 83: 835-870.
16. Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M, (2008) Growth factors and cytokines in wound healing. Wound Rep Reg 16: 585-601.
17. Beer HD, Fassler R, Werner S, (2000) Glucocorticoid-regulated gene expression during cutaneous wound repair. Vitamins and hormones 59: 217-239.
18. Pérez P, Page A, Bravo A, Del Río M, Gimenez-Conti I, et al. (2001) Altered skin development and impaired proliferative and inflammatory responses in transgenic mice overexpressing the glucocorticoid receptor. FASEB J 15: 2030-2032.
19. Donet E, Bosch P, Sanchis A, Bayo P, Ramírez A, et al. (2008) Transrepression function of the glucocorticoid receptor regulates eyelid development and keratinocyte proliferation but is not sufficient to prevent skin chronic inflammation. Mol Endocrinol 22: 799-812.
20. Lai JJ, Lai KP, Chuang KH, Chang P, (2009) Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-α expression. J Clin Invest 119 (12): 3739-3751.
21. Bayo P, Sanchis A, Bravo A, Cascallana JL, Buder K, et al. (2008) Glucocorticoid receptor is required for skin barrier competence. Endocrinology 149: 1377-1388.
22. Sanchis A, Bayo P, Sevilla L, Pérez P, (2010) Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development. International J Dev Biol 54 (10): 1473-1480.
23. Stojadinovic O, Brem H, Vouthounis C, Lee B, Fallon J, et al. (2005) The role of β-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol 167: 59-69.
24. Choi EH, Demerjian M, Crumrine D, Brown BE, Mauro T, et al. (2005) Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function. FASEB J 19: 1332-1334.
25. Cascallana JL, Bravo A, Donet E, Leis H, Lara MF, et al. (2005) Ectoderm-Targeted Overexpression of the glucocorticoid Receptor Induces Hypohidrotic Ectodermal Dysplasia. Endocrinology 146: 2629-2638.
26. Slominski A, Wortsman J, Paus R, Elias PM, Tobin DJ, et al. (2008) Skin as an endocrine organ:implications for its function. Drug Discov Today Dis Mech 5: 137-144.
27. Vukelic S, Stojadinovic O, Pastar I, Rabach M, Krzyzanowska A, et al. (2011) Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem.
28. Grose R, Werner S, Kessler D, Tuckermann J, Huggel K, et al. (2002) A role for endogenous glucocorticoids in wound repair. EMB rep 3 (6): 575-582.
29. Lee B, Vouthounis C, Stojadinovic O, Brem H, Im M, et al. (2005) From an enhanceosome to a repressosome: molecular antagonism between glucocorticoids and EGF leads to inhibition of wound healing. J Mol Biol 345: 1083-1097.
30. Ramot Y, Paus R, Tiede S, Zlotogorski A, (2009) Endocrine controls of keratin expression Bio Essays 31: 389-399.
31. Radoja N, Komine M, Jho SH, Blumenberg M, Tomic-Canic M, (2000) Novel mechanism of steroid action in skin through glucocorticoid receptor monomers. Mol Cell Biol 2000 20: 4328-433.
32. Takayama S, Rogatsky I, Schwarcz LE, Darimont BD, (2006) The glucocorticoid receptor represses cyclin D1 by targeting the Tcf-beta-catenin complex. J Biol Chem 281 (26): 17856-17863.
33. Turchi L, Chassot AA, Rezzonico R, Yeow K, Loubat A, et al. (2002) Dynamic Characterization of the Molecular Events During In Vitro Epidermal Wound Healing. J Invest Dermatol 119: 56-63.
34. Yemelyanov A, Czwornog J, Chebotaev D, Karseladze A, Kulevitch E, et al. (2007) Tumor suppressor activity of glucocorticoid receptor in the prostate. Oncogene 26 (13): 1885-1896.
35. De Bosscher K, (2010) Selective glucocorticoid receptor modulators. J Steroid Biochem Mol Biology 120: 96-104.
36. Komi-Kuramochi A, Kawano M, Oda Y, Asada M, Suzuki M, et al. (2005) Expression of fibroblast growth factors and their receptors during full-thickness skin wound healing in young and aged mice. J Endocrinol 186 (2): 273-289.