Tumor suppressor activity of glucocorticoid receptor in the prostate

Oncogene

Volumn 26, Issue 13, 2007, Pages 1885-1896

  Yemelyanov, A ^a   Czwornog, J ^a   Chebotaev, D ^a   Karseladze, A ^b   Kulevitch, E ^b   Yang, X ^a   Budunova, I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

Author keywords

Glucocorticoid receptor; MAPKs; PC marker; PIN; Prostate carcinoma; Transcription factor

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; ACTIVATING TRANSCRIPTION FACTOR 2; CCAAT ENHANCER BINDING PROTEIN ALPHA; CYCLIN D1; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HEPSIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTIVIRUS VECTOR; MASPIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; MYC PROTEIN; PROTEIN P21; PROTEIN P27; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR SRF; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOLECULAR MECHANICS; MONOLAYER CULTURE; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; UPREGULATION;

CELL LINE, TUMOR; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; PROSTATIC NEOPLASMS; RECEPTORS, GLUCOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33947500218     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209991     Document Type: Article

References (36)

1. Ananthanarayanan V, Deaton RJ, Yang XJ, Pins MR, Gann PH. (2005). Alpha-methylacyl-CoA Racemase (AMACR) expression in normal prostatic glands and high-grade prostatic intraepithelial neoplasia (HGPIN): association with diagnosis of prostate cancer. Prostate 63: 341-346.
2. Bourcier T, Forgez P, Borderie V, Scheer S, Rostene W, Laroche L. (2000). Regulation of human corneal epithelial cell proliferation and apoptosis by dexamethasone. Invest Ophthalmol Vis Sci 41: 4133-4141.
3. Bruna A, Nicolas M, Munoz A, Kyriakis JM, Caelles C. (2003). Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids. EMBO J 22: 6035-6044.
4. Budunova IV, Carbajal S, Kang H, Viaje A, Slaga TJ. (1997). Altered glucocorticoid receptor expression and function during mouse skin carcinogenesis. Mol Carcinogen 18: 177-185.
5. Chen Z, Fan Z, McNeal JE, Nolley R, Caldwell MC, Mahadevappa M et al. (2003). Hepsin and maspin are inversely expressed in laser capture microdissectioned prostate cancer. J Urol 169: 1316-1319.
6. De Bosscher K, Vanden Berghe W, Haegeman G. (2003). The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev 24: 488-522.
7. Dhanasekaran SM, Barrette TR, Ghosh D, Shah R, Varambally S, Kurachi K et al. (2001). Delineation of prognostic biomarkers in prostate cancer. Nature 412: 822-826.
8. Fakih M, Johnson CS, Trump DL. (2002). Glucocorticoids and treatment of prostate cancer: a preclinical and clinical review. Urology 60: 553-561.
9. Fixemer T, Remberger K, Bonkhoff H. (2003). Differential expression of the estrogen receptor beta (ERbeta) in human prostate tissue, premalignant changes, and in primary, metastatic, and recurrent prostatic adenocarcinoma. Prostate 54: 79-87.
10. Gioeli D, Black BE, Gordon V, Spencer A, Kesler CT, Eblen ST et al. (2006). Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization. Mol Endocrinol 20: 503-515.
11. Greenberg AK, Hu J, Basu S, Hay J, Reibman J, Yie TA et al. (2002). Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators. Am J Respir Cell Mol Biol 27: 320-328.
12. Greenstein S, Ghias K, Krett NL, Rosen ST. (2002). Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies. Clin Cancer Res 8: 1681-1694.
13. Grossmann ME, Huang H, Tindall DJ. (2001). Androgen receptor signaling in androgen-refractory prostate cancer. J Natl Cancer Inst 93: 1687-1697.
14. Jiang X, Norman M, Roth L, Li X. (2004). Protein-DNA array-based identification of transcription factor activities regulated by interaction with the glucocorticoid receptor. J Biol Chem 279: 38480-38485.
15. Jiang Z, Woda BA. (2004). Diagnostic utility of alpha-methylacyl CoA racemase (P504S) on prostate needle biopsy. Adv Anat Pathol 11: 316-321.
16. Kassel O, Sancono A, Kratzschmar J, Kreft B, Stassen M, Cato AC. (2001). Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1. EMBO J 20: 7108-7116.
17. Klezovitch O, Chevillet J, Mirosevich J, Roberts RL, Matusik RJ, Vasioukhin V. (2004). Hepsin promotes prostate cancer progression and metastasis. Cancer Cell 6: 185-195.
18. Koutsilieris M, Mitsiades C, Dimopoulos T, Vacalicos J, Lambou T, Tsintavis A et al. (2002). Combination of dexamethasone and a somatostatin analogue in the treatment of advanced prostate cancer. Expert Opin Invest Drugs 11: 283-293.
19. Li CL, Johnson GR. (1998). Clonal cultures in vitro for hematopoietic cells using semisolid agar medium. In: Celis JS (ed). Cell Biology: A Laboratory Handbook 2nd edn, vol. 1. Academic Press: San-Diego (CA), pp 172-177.
20. Maroni PD, Koul S, Meacham RB, Koul HK. (2004). Mitogen activated protein kinase signal transduction pathways in the prostate. Cell Commun Signal 2: 5-12.
21. Mimeault M, Pommery N, Henichart JP. (2003). New advances on prostate carcinogenesis and therapies: involvement of EGF-EGFR transduction system. Growth Factors 21: 1-14.
22. Mohler JL, Chen Y, Hamil K, Hall SH, Cidlowski JA, Wilson EM et al. (1996). Androgen and glucocorticoid receptors in the stroma and epithelium of prostatic hyperplasia and carcinoma. Clin Cancer Res 2: 889-895.
23. Necela BM, Cidlowski JA. (2004). Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells. Proc Am Thorac Soc 1: 239-246.
24. Nishimura K, Nonomura N, Satoh E, Harada Y, Nakayama M, Tokizane T et al. (2001). Potential mechanism for the effects of dexamethasone on growth of androgen-independent prostate cancer. J Natl Cancer Inst 93: 1739-1746.
25. Peterziel H, Mink S, Schonert A, Becker M, Klocker H, Cato AC. (1999). Rapid signalling by androgen receptor in prostate cancer cells. Oncogene 18: 6322-6329.
26. Quinn DI, Henshall SM, Sutherland RL. (2005). Molecular markers of prostate cancer outcome. Eur J Cancer 41: 858-887.
27. Ray DW. (1996). Molecular mechanisms of glucocorticoid resistance. J Endocrinol 149: 1-5.
28. Ricote M, Garcia-Tunon I, Bethencourt F, Fraile B, Onsurbe P, Paniagua R et al. (2006). The p38 transduction pathway in prostatic neoplasia. J Pathol 208: 401-407.
29. Rosenberg I. (1996). Protein Analysis and Purification: Benchtop Techniques. Birkhauser: Boston, MA, pp 103-109.
30. Schacke H, Docke WD, Asadullah K. (2002). Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 96: 23-43.
31. Schaefer JS, Zhang M. (2003). Role of maspin in tumor metastasis and angiogenesis. Curr Mol Med 3: 653-658.
32. Schug J, Overton CG. (2005). TESS: Transcription Element Search Software on the WWW. Eur J Cancer 41: 858-887 (http://www.cbil.upenn.edu/ cgi-bin/tess/tess).
33. Torlakovic E, Lilleby W, Berner A, Torlakovic G, Chibbar R, Furre T et al. (2005). Differential expression of steroid receptors in prostate tissues before and after radiation therapy for prostatic adenocarcinoma. Int J Cancer 117: 381-386.
34. Weaver I, Champagne F, Brown S, Dymov S, Sharma S, Meaney M et al. (2005). Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 25: 11045-11054.
35. Wu W, Chaudhuri S, Brickley DR, Pang D, Karrison T, Conzen SD. (2004). Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res 64: 1757-1764.
36. Zha S, Ferdinandusse S, Denis S, Wanders RJ, Ewing CM, Luo J et al. (2003). Alpha-methylacyl-CoA racemase as an androgen-independent growth modifier in prostate cancer. Cancer Res 63: 7365-7376.