메뉴 건너뛰기




Volumn 14, Issue 2, 2012, Pages 121-129

Using albumin to improve the therapeutic properties of diabetes treatments

Author keywords

Albiglutide; Albulin; Albumin; Exenatide; Glucagon like peptide 1; Insulin detemir; Liraglutide; Review

Indexed keywords

ALBIGLUTIDE; ALBUMIN; DRUG CARRIER; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; INSULIN DERIVATIVE; LIRAGLUTIDE; PLASMA PROTEIN; TASPOGLUTIDE;

EID: 84855356092     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2011.01482.x     Document Type: Review
Times cited : (14)

References (89)
  • 1
    • 84855359928 scopus 로고    scopus 로고
    • International Diabetes Federation. The global burden: epidemiology and morbidity. Available from URL: Accessed 16 December 2010
    • International Diabetes Federation. The global burden: epidemiology and morbidity. 2010. Available from URL: Accessed 16 December 2010.
    • (2010)
  • 2
    • 0038418746 scopus 로고    scopus 로고
    • Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart.
    • Vague P, Selam JL, Skeie S et al. Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart. Diabetes Care 2003; 26: 590-596.
    • (2003) Diabetes Care , vol.26 , pp. 590-596
    • Vague, P.1    Selam, J.L.2    Skeie, S.3
  • 3
    • 79952291919 scopus 로고    scopus 로고
    • GLP-1 for type 2 diabetes.
    • Ahren B. GLP-1 for type 2 diabetes. Exp Cell Res 2011; 317: 1239-1245.
    • (2011) Exp Cell Res , vol.317 , pp. 1239-1245
    • Ahren, B.1
  • 4
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1.
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007; 87: 1409-1439.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 5
    • 30344446232 scopus 로고    scopus 로고
    • The extraordinary ligand binding properties of human serum albumin.
    • Fasano M, Curry S, Terreno E et al. The extraordinary ligand binding properties of human serum albumin. IUBMB Life 2005; 57: 787-796.
    • (2005) IUBMB Life , vol.57 , pp. 787-796
    • Fasano, M.1    Curry, S.2    Terreno, E.3
  • 6
  • 7
    • 0016801988 scopus 로고
    • The characterization of two specific drug binding sites on human serum albumin.
    • Sudlow G, Birkett DJ, Wade DN. The characterization of two specific drug binding sites on human serum albumin. Mol Pharmacol 1975; 11: 824-832.
    • (1975) Mol Pharmacol , vol.11 , pp. 824-832
    • Sudlow, G.1    Birkett, D.J.2    Wade, D.N.3
  • 8
    • 0034634370 scopus 로고    scopus 로고
    • Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin.
    • Bhattacharya AA, Grune T, Curry S. Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin. J Mol Biol 2000; 303: 721-732.
    • (2000) J Mol Biol , vol.303 , pp. 721-732
    • Bhattacharya, A.A.1    Grune, T.2    Curry, S.3
  • 9
    • 19944387932 scopus 로고    scopus 로고
    • Insulin therapy: current alternatives.
    • Gomez-Perez FJ, Rull JA. Insulin therapy: current alternatives. Arch Med Res 2005; 36: 258-272.
    • (2005) Arch Med Res , vol.36 , pp. 258-272
    • Gomez-Perez, F.J.1    Rull, J.A.2
  • 10
    • 56949084877 scopus 로고    scopus 로고
    • Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles.
    • Kratz F. Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. J Control Release 2008; 132: 171-183.
    • (2008) J Control Release , vol.132 , pp. 171-183
    • Kratz, F.1
  • 11
    • 0029619489 scopus 로고
    • Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo.
    • Kurtzhals P, Havelund S, Jonassen I et al. Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo. Biochem J 1995; 312(Pt 3): 725-731.
    • (1995) Biochem J , vol.312 , Issue.PART 3 , pp. 725-731
    • Kurtzhals, P.1    Havelund, S.2    Jonassen, I.3
  • 13
    • 1042269718 scopus 로고    scopus 로고
    • Review article: albumin as a drug-biological effects of albumin unrelated to oncotic pressure.
    • Evans TW. Review article: albumin as a drug-biological effects of albumin unrelated to oncotic pressure. Aliment Pharmacol Ther 2002; 16(Suppl. 5): 6-11.
    • (2002) Aliment Pharmacol Ther , vol.16 , Issue.SUPPL. 5 , pp. 6-11
    • Evans, T.W.1
  • 14
    • 0038044655 scopus 로고    scopus 로고
    • Liver failure: basis of benefit of therapy with the molecular adsorbents recirculating system.
    • Sen S, Jalan R, Williams R. Liver failure: basis of benefit of therapy with the molecular adsorbents recirculating system. Int J Biochem Cell Biol 2003; 35: 1306-1311.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 1306-1311
    • Sen, S.1    Jalan, R.2    Williams, R.3
  • 15
    • 0028094666 scopus 로고
    • A new structural transition of serum albumin dependent on the state of Cys34. Detection by 1H-NMR spectroscopy.
    • Christodoulou J, Sadler PJ, Tucker A. A new structural transition of serum albumin dependent on the state of Cys34. Detection by 1H-NMR spectroscopy. Eur J Biochem 1994; 225: 363-368.
    • (1994) Eur J Biochem , vol.225 , pp. 363-368
    • Christodoulou, J.1    Sadler, P.J.2    Tucker, A.3
  • 16
    • 0036783536 scopus 로고    scopus 로고
    • Interactions of antitumoral platinum-group metallodrugs with albumin.
    • Espósito BP, Najjar R. Interactions of antitumoral platinum-group metallodrugs with albumin. Coord Chem Rev 2002; 232: 137-149.
    • (2002) Coord Chem Rev , vol.232 , pp. 137-149
    • Espósito, B.P.1    Najjar, R.2
  • 17
    • 0027286545 scopus 로고
    • NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.
    • Keaney JF Jr, Simon DI, Stamler JS et al. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. J Clin Invest 1993; 91: 1582-1589.
    • (1993) J Clin Invest , vol.91 , pp. 1582-1589
    • Keaney, J.F.1    Simon, D.I.2    Stamler, J.S.3
  • 18
    • 0036599564 scopus 로고    scopus 로고
    • Practical aspects of the ligand-binding and enzymatic properties of human serum albumin.
    • Kragh-Hansen U, Chuang VT, Otagiri M. Practical aspects of the ligand-binding and enzymatic properties of human serum albumin. Biol Pharm Bull 2002; 25: 695-704.
    • (2002) Biol Pharm Bull , vol.25 , pp. 695-704
    • Kragh-Hansen, U.1    Chuang, V.T.2    Otagiri, M.3
  • 19
  • 20
    • 0015881583 scopus 로고
    • Macromolecular ligands of exchangeable copper, zinc and cadmium in human serum.
    • Giroux EL, Henkin RI. Macromolecular ligands of exchangeable copper, zinc and cadmium in human serum. Bioinorg Chem 1973; 2: 125-133.
    • (1973) Bioinorg Chem , vol.2 , pp. 125-133
    • Giroux, E.L.1    Henkin, R.I.2
  • 21
    • 0021236274 scopus 로고
    • Albumin bound and alpha 2-macroglobulin bound zinc concentrations in the sera of healthy adults.
    • Foote JW, Delves HT. Albumin bound and alpha 2-macroglobulin bound zinc concentrations in the sera of healthy adults. J Clin Pathol 1984; 37: 1050-1054.
    • (1984) J Clin Pathol , vol.37 , pp. 1050-1054
    • Foote, J.W.1    Delves, H.T.2
  • 22
    • 59149099932 scopus 로고    scopus 로고
    • Albumin as a zinc carrier: properties of its high-affinity zinc-binding site.
    • Lu J, Stewart AJ, Sadler PJ, Pinheiro TJ, Blindauer CA. Albumin as a zinc carrier: properties of its high-affinity zinc-binding site. Biochem Soc Trans 2008; 36(Pt 6): 1317-1321.
    • (2008) Biochem Soc Trans , vol.36 , Issue.PART 6 , pp. 1317-1321
    • Lu, J.1    Stewart, A.J.2    Sadler, P.J.3    Pinheiro, T.J.4    Blindauer, C.A.5
  • 23
    • 77950301323 scopus 로고    scopus 로고
    • Zinc(II) complexes of the second-generation quinolone antibacterial drug enrofloxacin: structure and DNA or albumin interaction.
    • Tarushi A, Raptopoulou CP, Psycharis V, Terzis A, Psomas G, Kessissoglou DP. Zinc(II) complexes of the second-generation quinolone antibacterial drug enrofloxacin: structure and DNA or albumin interaction. Bioorg Med Chem 2010; 18: 2678-2685.
    • (2010) Bioorg Med Chem , vol.18 , pp. 2678-2685
    • Tarushi, A.1    Raptopoulou, C.P.2    Psycharis, V.3    Terzis, A.4    Psomas, G.5    Kessissoglou, D.P.6
  • 25
    • 0034815784 scopus 로고    scopus 로고
    • An analog of the human albumin N-terminus (Asp-Ala-His-Lys) prevents formation of copper-induced reactive oxygen species.
    • Bar-Or D, Rael LT, Lau EP et al. An analog of the human albumin N-terminus (Asp-Ala-His-Lys) prevents formation of copper-induced reactive oxygen species. Biochem Biophys Res Commun 2001; 284: 856-862.
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 856-862
    • Bar-Or, D.1    Rael, L.T.2    Lau, E.P.3
  • 26
    • 0024286990 scopus 로고
    • Albumin-an important extracellular antioxidant?
    • Halliwell B. Albumin-an important extracellular antioxidant? Biochem Pharmacol 1988; 37: 569-571.
    • (1988) Biochem Pharmacol , vol.37 , pp. 569-571
    • Halliwell, B.1
  • 27
    • 0034959203 scopus 로고    scopus 로고
    • Effect of oxidative stress on the structure and function of human serum albumin.
    • Anraku M, Yamasaki K, Maruyama T, Kragh-Hansen U, Otagiri M. Effect of oxidative stress on the structure and function of human serum albumin. Pharm Res 2001; 18: 632-639.
    • (2001) Pharm Res , vol.18 , pp. 632-639
    • Anraku, M.1    Yamasaki, K.2    Maruyama, T.3    Kragh-Hansen, U.4    Otagiri, M.5
  • 28
    • 1242337279 scopus 로고    scopus 로고
    • Esterase-like activity of serum albumin: characterization of its structural chemistry using p-nitrophenyl esters as substrates.
    • Sakurai Y, Ma SF, Watanabe H et al. Esterase-like activity of serum albumin: characterization of its structural chemistry using p-nitrophenyl esters as substrates. Pharm Res 2004; 21: 285-292.
    • (2004) Pharm Res , vol.21 , pp. 285-292
    • Sakurai, Y.1    Ma, S.F.2    Watanabe, H.3
  • 29
    • 0015027072 scopus 로고
    • Heme binding and transport-a spectrophotometric study of plasma glycoglobulin hemochromogens.
    • Drabkin DL. Heme binding and transport-a spectrophotometric study of plasma glycoglobulin hemochromogens. Proc Natl Acad Sci U S A 1971; 68: 609-613.
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 609-613
    • Drabkin, D.L.1
  • 30
    • 68949181542 scopus 로고    scopus 로고
    • Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality.
    • Jalan R, Schnurr K, Mookerjee RP et al. Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality. Hepatology 2009; 50: 555-564.
    • (2009) Hepatology , vol.50 , pp. 555-564
    • Jalan, R.1    Schnurr, K.2    Mookerjee, R.P.3
  • 31
    • 0032710711 scopus 로고    scopus 로고
    • Albumin dialysis: effective removal of copper in a patient with fulminant Wilson disease and successful bridging to liver transplantation: a new possibility for the elimination of protein-bound toxins.
    • Kreymann B, Seige M, Schweigart U, Kopp KF, Classen M. Albumin dialysis: effective removal of copper in a patient with fulminant Wilson disease and successful bridging to liver transplantation: a new possibility for the elimination of protein-bound toxins. J Hepatol 1999; 31: 1080-1085.
    • (1999) J Hepatol , vol.31 , pp. 1080-1085
    • Kreymann, B.1    Seige, M.2    Schweigart, U.3    Kopp, K.F.4    Classen, M.5
  • 32
    • 0028239795 scopus 로고
    • Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation.
    • Neuzil J, Stocker R. Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J Biol Chem 1994; 269: 16712-16719.
    • (1994) J Biol Chem , vol.269 , pp. 16712-16719
    • Neuzil, J.1    Stocker, R.2
  • 33
    • 37749045276 scopus 로고    scopus 로고
    • Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis.
    • Hassanein TI, Tofteng F, Brown RS Jr et al. Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis. Hepatology 2007; 46: 1853-1862.
    • (2007) Hepatology , vol.46 , pp. 1853-1862
    • Hassanein, T.I.1    Tofteng, F.2    Brown, R.S.3
  • 34
    • 0036001387 scopus 로고    scopus 로고
    • Pharmaceutical strategies utilizing recombinant human serum albumin.
    • Chuang VT, Kragh-Hansen U, Otagiri M. Pharmaceutical strategies utilizing recombinant human serum albumin. Pharm Res 2002; 19: 569-577.
    • (2002) Pharm Res , vol.19 , pp. 569-577
    • Chuang, V.T.1    Kragh-Hansen, U.2    Otagiri, M.3
  • 35
    • 33644500755 scopus 로고    scopus 로고
    • Summary of recombinant human serum albumin development.
    • Kobayashi K. Summary of recombinant human serum albumin development. Biologicals 2006; 34: 55-59.
    • (2006) Biologicals , vol.34 , pp. 55-59
    • Kobayashi, K.1
  • 36
    • 53349171633 scopus 로고    scopus 로고
    • Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology.
    • Tijink BM, Laeremans T, Budde M et al. Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology. Mol Cancer Ther 2008; 7: 2288-2297.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2288-2297
    • Tijink, B.M.1    Laeremans, T.2    Budde, M.3
  • 37
    • 0242416983 scopus 로고    scopus 로고
    • Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis.
    • Wunder A, Muller-Ladner U, Stelzer EH et al. Albumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis. J Immunol 2003; 170: 4793-4801.
    • (2003) J Immunol , vol.170 , pp. 4793-4801
    • Wunder, A.1    Muller-Ladner, U.2    Stelzer, E.H.3
  • 38
    • 53449102958 scopus 로고    scopus 로고
    • Use of albumin fusion technology to prolong the half-life of recombinant factor VIIa.
    • Schulte S. Use of albumin fusion technology to prolong the half-life of recombinant factor VIIa. Thromb Res 2008; 122(Suppl. 4): S14-19.
    • (2008) Thromb Res , vol.122 , Issue.SUPPL. 4
    • Schulte, S.1
  • 39
    • 49649089488 scopus 로고    scopus 로고
    • Albinterferon alfa-2b dosed every two or four weeks in interferon-naive patients with genotype 1 chronic hepatitis C.
    • Zeuzem S, Yoshida EM, Benhamou Y et al. Albinterferon alfa-2b dosed every two or four weeks in interferon-naive patients with genotype 1 chronic hepatitis C. Hepatology 2008; 48: 407-417.
    • (2008) Hepatology , vol.48 , pp. 407-417
    • Zeuzem, S.1    Yoshida, E.M.2    Benhamou, Y.3
  • 41
    • 33644551889 scopus 로고    scopus 로고
    • A phase I/II study evaluating escalating doses of recombinant human albumin-interferon-alpha fusion protein in chronic hepatitis C patients who have failed previous interferon-alpha-based therapy.
    • Balan V, Nelson DR, Sulkowski MS et al. A phase I/II study evaluating escalating doses of recombinant human albumin-interferon-alpha fusion protein in chronic hepatitis C patients who have failed previous interferon-alpha-based therapy. Antivir Ther 2006; 11: 35-45.
    • (2006) Antivir Ther , vol.11 , pp. 35-45
    • Balan, V.1    Nelson, D.R.2    Sulkowski, M.S.3
  • 42
    • 0036827834 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys.
    • Osborn BL, Olsen HS, Nardelli B et al. Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys. J Pharmacol Exp Ther 2002; 303: 540-548.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 540-548
    • Osborn, B.L.1    Olsen, H.S.2    Nardelli, B.3
  • 43
    • 0342314489 scopus 로고    scopus 로고
    • A novel macromolecular prodrug concept exploiting endogenous serum albumin as a drug carrier for cancer chemotherapy.
    • Kratz F, Muller-Driver R, Hofmann I, Drevs J, Unger C. A novel macromolecular prodrug concept exploiting endogenous serum albumin as a drug carrier for cancer chemotherapy. J Med Chem 2000; 43: 1253-1256.
    • (2000) J Med Chem , vol.43 , pp. 1253-1256
    • Kratz, F.1    Muller-Driver, R.2    Hofmann, I.3    Drevs, J.4    Unger, C.5
  • 44
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer.
    • Gradishar WJ, Tjulandin S, Davidson N et al. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol 2005; 23: 7794-7803.
    • (2005) J Clin Oncol , vol.23 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3
  • 45
    • 8944245005 scopus 로고    scopus 로고
    • Multicenter, randomized comparative study of two doses of paclitaxel in patients with metastatic breast cancer.
    • Nabholtz JM, Gelmon K, Bontenbal M et al. Multicenter, randomized comparative study of two doses of paclitaxel in patients with metastatic breast cancer. J Clin Oncol 1996; 14: 1858-1867.
    • (1996) J Clin Oncol , vol.14 , pp. 1858-1867
    • Nabholtz, J.M.1    Gelmon, K.2    Bontenbal, M.3
  • 46
    • 0036096946 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel.
    • Ibrahim NK, Desai N, Legha S et al. Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel. Clin Cancer Res 2002; 8: 1038-1044.
    • (2002) Clin Cancer Res , vol.8 , pp. 1038-1044
    • Ibrahim, N.K.1    Desai, N.2    Legha, S.3
  • 47
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes.
    • Nathan DM, Buse JB, Davidson MB et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009; 32: 193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 48
    • 69249208672 scopus 로고    scopus 로고
    • Nocturnal hypoglycaemia in type 1 diabetes-frequency and predictive factors.
    • Woodward A, Weston P, Casson IF, Gill GV. Nocturnal hypoglycaemia in type 1 diabetes-frequency and predictive factors. QJM 2009; 102: 603-607.
    • (2009) QJM , vol.102 , pp. 603-607
    • Woodward, A.1    Weston, P.2    Casson, I.F.3    Gill, G.V.4
  • 49
    • 20444408424 scopus 로고    scopus 로고
    • Frequency and predictors of hypoglycaemia in type 1 and insulin-treated type 2 diabetes: a population-based study.
    • Donnelly LA, Morris AD, Frier BM et al. Frequency and predictors of hypoglycaemia in type 1 and insulin-treated type 2 diabetes: a population-based study. Diabet Med 2005; 22: 749-755.
    • (2005) Diabet Med , vol.22 , pp. 749-755
    • Donnelly, L.A.1    Morris, A.D.2    Frier, B.M.3
  • 50
    • 33947302393 scopus 로고    scopus 로고
    • Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index.
    • Raslova K, Tamer SC, Clauson P, Karl D. Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index. Clin Drug Investig 2007; 27: 279-285.
    • (2007) Clin Drug Investig , vol.27 , pp. 279-285
    • Raslova, K.1    Tamer, S.C.2    Clauson, P.3    Karl, D.4
  • 51
    • 47349095951 scopus 로고    scopus 로고
    • Prospective randomized study for optimal insulin therapy in type 2 diabetic patients with secondary failure.
    • Miyashita Y, Nishimura R, Nemoto M et al. Prospective randomized study for optimal insulin therapy in type 2 diabetic patients with secondary failure. Cardiovasc Diabetol 2008; 7: 16.
    • (2008) Cardiovasc Diabetol , vol.7 , pp. 16
    • Miyashita, Y.1    Nishimura, R.2    Nemoto, M.3
  • 53
    • 0031690490 scopus 로고    scopus 로고
    • Insulin degradation: progress and potential.
    • Duckworth WC, Bennett RG, Hamel FG. Insulin degradation: progress and potential. Endocr Rev 1998; 19: 608-624.
    • (1998) Endocr Rev , vol.19 , pp. 608-624
    • Duckworth, W.C.1    Bennett, R.G.2    Hamel, F.G.3
  • 54
    • 2342621441 scopus 로고    scopus 로고
    • Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes: a randomized clinical trial.
    • Home P, Bartley P, Russell-Jones D et al. Insulin detemir offers improved glycemic control compared with NPH insulin in people with type 1 diabetes: a randomized clinical trial. Diabetes Care 2004; 27: 1081-1087.
    • (2004) Diabetes Care , vol.27 , pp. 1081-1087
    • Home, P.1    Bartley, P.2    Russell-Jones, D.3
  • 55
    • 0035146436 scopus 로고    scopus 로고
    • Comparison of the soluble basal insulin analog insulin detemir with NPH insulin: a randomized open crossover trial in type 1 diabetic subjects on basal-bolus therapy.
    • Hermansen K, Madsbad S, Perrild H, Kristensen A, Axelsen M. Comparison of the soluble basal insulin analog insulin detemir with NPH insulin: a randomized open crossover trial in type 1 diabetic subjects on basal-bolus therapy. Diabetes Care 2001; 24: 296-301.
    • (2001) Diabetes Care , vol.24 , pp. 296-301
    • Hermansen, K.1    Madsbad, S.2    Perrild, H.3    Kristensen, A.4    Axelsen, M.5
  • 56
    • 33746391488 scopus 로고    scopus 로고
    • A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes.
    • Hermansen K, Davies M, Derezinski T, Martinez Ravn G, Clauson P, Home P. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care 2006; 29: 1269-1274.
    • (2006) Diabetes Care , vol.29 , pp. 1269-1274
    • Hermansen, K.1    Davies, M.2    Derezinski, T.3    Martinez Ravn, G.4    Clauson, P.5    Home, P.6
  • 57
    • 77951150702 scopus 로고    scopus 로고
    • Euglycemic infusion of insulin detemir compared with human insulin appears to increase direct current brain potential response and reduces food intake while inducing similar systemic effects.
    • Hallschmid M, Jauch-Chara K, Korn O et al. Euglycemic infusion of insulin detemir compared with human insulin appears to increase direct current brain potential response and reduces food intake while inducing similar systemic effects. Diabetes 2010; 59: 1101-1107.
    • (2010) Diabetes , vol.59 , pp. 1101-1107
    • Hallschmid, M.1    Jauch-Chara, K.2    Korn, O.3
  • 58
    • 82955198015 scopus 로고    scopus 로고
    • Insulin degludec is a new-generation ultra-long-acting basal insulin designed to maintain full metabolic effect while minimizing mitogenic potential (Abstract 1406-p).
    • Nishimura E, Sorensen AR, Hansen BF et al. Insulin degludec is a new-generation ultra-long-acting basal insulin designed to maintain full metabolic effect while minimizing mitogenic potential (Abstract 1406-p). Diabetes 2010; 59(Suppl. 1): A375.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Nishimura, E.1    Sorensen, A.R.2    Hansen, B.F.3
  • 59
    • 79956110739 scopus 로고    scopus 로고
    • Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine.
    • Birkeland KI, Home PD, Wendisch U et al. Insulin degludec in type 1 diabetes: a randomized controlled trial of a new-generation ultra-long-acting insulin compared with insulin glargine. Diabetes Care 2011; 34: 661-665.
    • (2011) Diabetes Care , vol.34 , pp. 661-665
    • Birkeland, K.I.1    Home, P.D.2    Wendisch, U.3
  • 60
    • 84873073926 scopus 로고    scopus 로고
    • Note
    • ConjuChem Biotechnologies. About DAC™. Available from URL: Accessed 15 December 2010.
  • 61
    • 19944428668 scopus 로고    scopus 로고
    • Development of a long-acting insulin analog using albumin fusion technology.
    • Duttaroy A, Kanakaraj P, Osborn BL et al. Development of a long-acting insulin analog using albumin fusion technology. Diabetes 2005; 54: 251-258.
    • (2005) Diabetes , vol.54 , pp. 251-258
    • Duttaroy, A.1    Kanakaraj, P.2    Osborn, B.L.3
  • 62
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes.
    • Nauck M, Stockmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986; 29: 46-52.
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 63
    • 24944577486 scopus 로고    scopus 로고
    • Alpha cell function in health and disease: influence of glucagon-like peptide-1.
    • Dunning BE, Foley JE, Ahren B. Alpha cell function in health and disease: influence of glucagon-like peptide-1. Diabetologia 2005; 48: 1700-1713.
    • (2005) Diabetologia , vol.48 , pp. 1700-1713
    • Dunning, B.E.1    Foley, J.E.2    Ahren, B.3
  • 64
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans.
    • Nauck MA, Niedereichholz U, Ettler R et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997; 273(5 Pt 1): E981-E988.
    • (1997) Am J Physiol , vol.273 , Issue.5 PART 1
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3
  • 65
    • 0032966882 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2.
    • Gutzwiller JP, Drewe J, Goke B et al. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol 1999; 276(5 Pt 2): R1541-R1544.
    • (1999) Am J Physiol , vol.276 , Issue.5 PART 2
    • Gutzwiller, J.P.1    Drewe, J.2    Goke, B.3
  • 66
    • 12244264206 scopus 로고    scopus 로고
    • The role of GLP-1 in the life and death of pancreatic beta cells.
    • Perfetti R, Hui H. The role of GLP-1 in the life and death of pancreatic beta cells. Horm Metab Res 2004; 36: 804-810.
    • (2004) Horm Metab Res , vol.36 , pp. 804-810
    • Perfetti, R.1    Hui, H.2
  • 67
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects.
    • Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ. Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 1995; 44: 1126-1131.
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3    Pridal, L.4    Willms, B.5    Holst, J.J.6
  • 68
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes.
    • Buse JB, Henry RR, Han J et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004; 27: 2628-2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3
  • 69
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes.
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005; 28: 1092-1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 70
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea.
    • Kendall DM, Riddle MC, Rosenstock J et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005; 28: 1083-1091.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3
  • 71
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years.
    • Klonoff DC, Buse JB, Nielsen LL et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin 2008; 24: 275-286.
    • (2008) Curr Med Res Opin , vol.24 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3
  • 72
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study.
    • Moretto TJ, Milton DR, Ridge TD et al. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2008; 30: 1448-1460.
    • (2008) Clin Ther , vol.30 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3
  • 73
    • 16244385334 scopus 로고    scopus 로고
    • Exenatide: a nover treatment of type 2 diabetes.
    • Ahren B. Exenatide: a nover treatment of type 2 diabetes. Therapy 2005; 2: 207-222.
    • (2005) Therapy , vol.2 , pp. 207-222
    • Ahren, B.1
  • 74
    • 84873061207 scopus 로고    scopus 로고
    • Exenatide (Byetta) Prescribing Information. Available from URL: Accessed 25 February 2011.
    • Exenatide (Byetta) Prescribing Information. Available from URL: Accessed 25 February 2011.
  • 75
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study.
    • Drucker DJ, Buse JB, Taylor K et al. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008; 372: 1240-1250.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 76
    • 77953828230 scopus 로고    scopus 로고
    • DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks.
    • Buse JB, Drucker DJ, Taylor KL et al. DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks. Diabetes Care 2010; 33: 1255-1261.
    • (2010) Diabetes Care , vol.33 , pp. 1255-1261
    • Buse, J.B.1    Drucker, D.J.2    Taylor, K.L.3
  • 77
    • 77956894291 scopus 로고    scopus 로고
    • Glycaemic control with liraglutide: the phase 3 trial programme.
    • Raskin P, Mora PF. Glycaemic control with liraglutide: the phase 3 trial programme. Int J Clin Pract Suppl 2010; 64: 21-27.
    • (2010) Int J Clin Pract Suppl , vol.64 , pp. 21-27
    • Raskin, P.1    Mora, P.F.2
  • 78
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6).
    • Buse JB, Rosenstock J, Sesti G et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009; 374: 39-47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 79
    • 3342984674 scopus 로고    scopus 로고
    • The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes.
    • Harder H, Nielsen L, Tu DT, Astrup A. The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes. Diabetes Care 2004; 27: 1915-1921.
    • (2004) Diabetes Care , vol.27 , pp. 1915-1921
    • Harder, H.1    Nielsen, L.2    Tu, D.T.3    Astrup, A.4
  • 80
    • 73249118222 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of liraglutide, a long-acting, potent glucagon-like peptide-1 analog.
    • Meece J. Pharmacokinetics and pharmacodynamics of liraglutide, a long-acting, potent glucagon-like peptide-1 analog. Pharmacotherapy 2009; 29(12 Pt 2): 33S-42S.
    • (2009) Pharmacotherapy , vol.29 , Issue.12 PART 2
    • Meece, J.1
  • 81
    • 77951293658 scopus 로고    scopus 로고
    • Taspoglutide, an analog of human glucagon-like peptide-1 with enhanced stability and in vivo potency.
    • Sebokova E, Christ AD, Wang H et al. Taspoglutide, an analog of human glucagon-like peptide-1 with enhanced stability and in vivo potency. Endocrinology 2010; 151: 2474-2482.
    • (2010) Endocrinology , vol.151 , pp. 2474-2482
    • Sebokova, E.1    Christ, A.D.2    Wang, H.3
  • 82
    • 78649707525 scopus 로고    scopus 로고
    • Discovery and characterization of taspoglutide, a novel analogue of human glucagon-like peptide-1, engineered for sustained therapeutic activity in type 2 diabetes.
    • Dong JZ, Shen Y, Zhang J, Tsomaia N, Mierke DF, Taylor JE. Discovery and characterization of taspoglutide, a novel analogue of human glucagon-like peptide-1, engineered for sustained therapeutic activity in type 2 diabetes. Diabetes Obes Metab 2011; 13: 19-25.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 19-25
    • Dong, J.Z.1    Shen, Y.2    Zhang, J.3    Tsomaia, N.4    Mierke, D.F.5    Taylor, J.E.6
  • 83
    • 67649523294 scopus 로고    scopus 로고
    • Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study.
    • Nauck MA, Ratner RE, Kapitza C, Berria R, Boldrin M, Balena R. Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study. Diabetes Care 2009; 32: 1237-1243.
    • (2009) Diabetes Care , vol.32 , pp. 1237-1243
    • Nauck, M.A.1    Ratner, R.E.2    Kapitza, C.3    Berria, R.4    Boldrin, M.5    Balena, R.6
  • 84
    • 70349664297 scopus 로고    scopus 로고
    • Albiglutide Study Group. Potential of albiglutide, a long-acting GLP-1 receptor agonist, in type 2 diabetes: a randomized controlled trial exploring weekly, biweekly, and monthly dosing.
    • Rosenstock J, Reusch J, Bush M, Yang F, Stewart M. Albiglutide Study Group. Potential of albiglutide, a long-acting GLP-1 receptor agonist, in type 2 diabetes: a randomized controlled trial exploring weekly, biweekly, and monthly dosing. Diabetes Care 2009; 32: 1880-1886.
    • (2009) Diabetes Care , vol.32 , pp. 1880-1886
    • Rosenstock, J.1    Reusch, J.2    Bush, M.3    Yang, F.4    Stewart, M.5
  • 85
    • 57349168543 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes.
    • Matthews JE, Stewart MW, De Boever EH et al. Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes. J Clin Endocrinol Metab 2008; 93: 4810-4817.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4810-4817
    • Matthews, J.E.1    Stewart, M.W.2    De Boever, E.H.3
  • 86
    • 41349098117 scopus 로고    scopus 로고
    • An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis.
    • Baggio LL, Huang Q, Cao X, Drucker DJ. An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis. Gastroenterology 2008; 134: 1137-1147.
    • (2008) Gastroenterology , vol.134 , pp. 1137-1147
    • Baggio, L.L.1    Huang, Q.2    Cao, X.3    Drucker, D.J.4
  • 87
    • 79953040963 scopus 로고    scopus 로고
    • An overview of once-weekly GLP-1 receptor agonists-available efficacy and safety data and perspectives for the future.
    • Madsbad S, Kielgast U, Asmar M, Deacon C, Torekov SS, Holst JJ. An overview of once-weekly GLP-1 receptor agonists-available efficacy and safety data and perspectives for the future. Diabetes Obes Metab 2011; 13: 394-407.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 394-407
    • Madsbad, S.1    Kielgast, U.2    Asmar, M.3    Deacon, C.4    Torekov, S.S.5    Holst, J.J.6
  • 88
    • 77955830619 scopus 로고    scopus 로고
    • Synthesis and evaluation of human serum albumin-modified exendin-4 conjugate via heterobifunctional polyethylene glycol linkage with protracted hypoglycemic efficacy.
    • Kim I, Kim TH, Ma K et al. Synthesis and evaluation of human serum albumin-modified exendin-4 conjugate via heterobifunctional polyethylene glycol linkage with protracted hypoglycemic efficacy. Bioconjug Chem 2010; 21: 1513-1519.
    • (2010) Bioconjug Chem , vol.21 , pp. 1513-1519
    • Kim, I.1    Kim, T.H.2    Ma, K.3
  • 89


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.