Comparison of the soluble basal insulin analog insulin detemir with NPH insulin: A randomized open crossover trial in type 1 diabetic subjects on basal-bolus therapy

Diabetes Care

Volumn 24, Issue 2, 2001, Pages 296-301

  Hermansen, Kjeld ^a   Madsbad, Sten ^b   Perrild, Hans ^c   Kristensen, Allan ^d   Axelsen, Mads ^d  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b HVIDOVRE HOSPITAL   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

^d NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN DETEMIR; ISOPHANE INSULIN; NEUTRAL INSULIN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; DOSE RESPONSE; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MAJOR CLINICAL STUDY; RANDOMIZED CONTROLLED TRIAL;

EID: 0035146436     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.24.2.296     Document Type: Article

References (16)

1. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
2. The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus
3. Clinical factors influencing the absorption of 1251-NPH insulin in diabetic patients
4. Inadequate suspension of neutral protamine Hagedorn (NPH) insulin in pens
5. Insulin analogs with improved pharmacokinetic profiles
6. Crystal structure of a prolonged-acting insulin with albumin-binding properties
7. Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs
8. Albumin binding of insulins acylated with fatty acids: Characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo
9. Time-action profile of the soluble, fatty acid acylated, long-acting insulin analogue NN 304
10. Reduced pharmacokinetic (PK) variability of a novel, long-acting insulin analog
11. Pharmacokinetic and pharmacodynamic properties of long-acting insulin analog NN 304 in comparison to NPH insulin in humans
12. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor
13. Fructosamine: A new approach to the estimation of serum glycosylprotein: An index of diabetic control
14. Glycated hemoglobin: Methodologies and clinical applications
15. The action profiles of human NPH insulin preparations
16. Absorption of isophane (NPH) insulin and its clinical implications