메뉴 건너뛰기




Volumn 64, Issue SUPPL. 167, 2010, Pages 21-27

Glycaemic control with liraglutide: The phase 3 trial programme

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIMEPIRIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; HEMOGLOBIN A1C; INCRETIN; INSULIN GLARGINE; LIRAGLUTIDE; METFORMIN; ORAL ANTIDIABETIC AGENT; PLACEBO; ROSIGLITAZONE; SITAGLIPTIN; SULFONYLUREA;

EID: 77956894291     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2010.02496.x     Document Type: Review
Times cited : (9)

References (22)
  • 1
    • 0002294149 scopus 로고
    • New interpretation of oral glucose tolerance
    • McIntyre N, Holdsworth CD, Turner DS. New interpretation of oral glucose tolerance. Lancet 1964 2 : 20 1.
    • (1964) Lancet , vol.2 , pp. 20-1
    • McIntyre, N.1    Holdsworth, C.D.2    Turner, D.S.3
  • 2
    • 12244281855 scopus 로고    scopus 로고
    • Circulation and degradation of GIP and GLP-1
    • Deacon CF. Circulation and degradation of GIP and GLP-1. Horm Metab Res 2004 36 : 761 5.
    • (2004) Horm Metab Res , vol.36 , pp. 761-5
    • Deacon, C.F.1
  • 3
    • 0034108646 scopus 로고    scopus 로고
    • Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
    • Knudsen LB, Nielsen PF, Huusfeldt PO et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 2000 43 : 1664 9.
    • (2000) J Med Chem , vol.43 , pp. 1664-9
    • Knudsen, L.B.1    Nielsen, P.F.2    Huusfeldt, P.O.3
  • 4
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • Agersø H, Jensen LB, Elbrønd B, Rolan P, Zdravkovic M. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 2002 45 : 195 202.
    • (2002) Diabetologia , vol.45 , pp. 195-202
    • Agersø, H.1    Jensen, L.B.2    Elbrønd, B.3    Rolan, P.4    Zdravkovic, M.5
  • 5
    • 57649231326 scopus 로고    scopus 로고
    • The molecular basis for the delayed absorption of the once-daily human GLP-1 analogue, liraglutide
    • Steensgaard DB, Thomsen JK, Olsen HB, Knudsen LB. The molecular basis for the delayed absorption of the once-daily human GLP-1 analogue, liraglutide. Diabetes 2008 57 (Suppl. 1 A164.
    • (2008) Diabetes , vol.57 , Issue.1
    • Steensgaard, D.B.1    Thomsen, J.K.2    Olsen, H.B.3    Knudsen, L.B.4
  • 6
    • 2342599057 scopus 로고    scopus 로고
    • One week's treatment with the long-acting glucagon like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduced endogenous glucose release in patients with type 2 diabetes
    • Degn KB, Juhl CB, Sturis J et al. One week's treatment with the long-acting glucagon like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduced endogenous glucose release in patients with type 2 diabetes. Diabetes 2004 53 : 1187 94.
    • (2004) Diabetes , vol.53 , pp. 1187-94
    • Degn, K.B.1    Juhl, C.B.2    Sturis, J.3
  • 7
    • 4344708602 scopus 로고    scopus 로고
    • No impairment of hypoglycemia counterregulation via glucagon with NN2211, a GLP-1 derivative, in subjects with type 2-diabetes
    • Nauck MA, El-Ouaghlidi A, Hompesch M, Jacobsen J, Elbrønd B. No impairment of hypoglycemia counterregulation via glucagon with NN2211, a GLP-1 derivative, in subjects with type 2-diabetes. Diabetes 2003 52 (Suppl. 1 A128.
    • (2003) Diabetes , vol.52 , Issue.1
    • Nauck, M.A.1    El-Ouaghlidi, A.2    Hompesch, M.3    Jacobsen, J.4    Elbrønd, B.5
  • 8
    • 33750288460 scopus 로고    scopus 로고
    • Five weeks of treatment with the GLP-1 analogue liraglutide improves glycemic control and lowers body weight in subjects with type 2 diabetes
    • NN2211-1499 Study Group.
    • Nauck MA, Hompesch M, Filipczak R et al. NN2211-1499 Study Group. Five weeks of treatment with the GLP-1 analogue liraglutide improves glycemic control and lowers body weight in subjects with type 2 diabetes. Exp Clin Endocrinol Diabetes 2006 114 : 417 23.
    • (2006) Exp Clin Endocrinol Diabetes , vol.114 , pp. 417-23
    • Nauck, M.A.1    Hompesch, M.2    Filipczak, R.3
  • 9
    • 2542451393 scopus 로고    scopus 로고
    • Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): A 12-week, double-blind, randomized, controlled trial
    • NN2211-1310 International Study Group.
    • Madsbad S, Schmitz O, Ranstam J, Jakobsen G, Matthews DR NN2211-1310 International Study Group. Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial. Diabetes Care 2004 27 : 1335 42.
    • (2004) Diabetes Care , vol.27 , pp. 1335-42
    • Madsbad, S.1    Schmitz, O.2    Ranstam, J.3    Jakobsen, G.4    Matthews, D.R.5
  • 10
    • 34249869806 scopus 로고    scopus 로고
    • Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes
    • Vilsbøll T, Zdravkovic M, Le-Thu T et al. Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes. Diabetes Care 2007 30 : 1608 10.
    • (2007) Diabetes Care , vol.30 , pp. 1608-10
    • Vilsbøll, T.1    Zdravkovic, M.2    Le-Thu, T.3
  • 11
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
    • Pratley R, Nauck M, Bailey T et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet 2010 375 : 1447 56.
    • (2010) Lancet , vol.375 , pp. 1447-56
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 12
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • American Diabetes Association, European Association for Study of Diabetes.
    • Nathan DM, Buse JB, Davidson MB et al. American Diabetes Association, European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009 32 : 193 203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 13
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • for the LEAD-3 (Mono) Study Group.
    • Garber A, Henry R, Ratner R et al. for the LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009 373 : 473 81.
    • (2009) Lancet , vol.373 , pp. 473-81
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 15
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes
    • Nauck MA, Frid A, Hermansen K et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes. Diabetes Care 2009 32 : 84 90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.A.1    Frid, A.2    Hermansen, K.3
  • 16
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brandle M et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med 2009 26 : 268 78.
    • (2009) Diabet Med , vol.26 , pp. 268-78
    • Marre, M.1    Shaw, J.2    Brandle, M.3
  • 17
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse J et al. Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD). Diabetes Care 2009 32 : 1224 30.
    • (2009) Diabetes Care , vol.32 , pp. 1224-30
    • Zinman, B.1    Gerich, J.2    Buse, J.3
  • 18
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • on behalf of the LEAD-5 (Liraglutide Effect and Action in Diabetes 5) met+SU Study Group.
    • Russell-Jones D, Vaag A, Schmitz O et al. on behalf of the LEAD-5 (Liraglutide Effect and Action in Diabetes 5) met+SU Study Group. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia 2009 52 (10 2046 55.
    • (2009) Diabetologia , vol.52 , Issue.10 , pp. 2046-55
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 19
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • LEAD 6 study group.
    • Buse J, Rosenstock J, Sesti G et al. LEAD 6 study group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009 374 : 39 47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.1    Rosenstock, J.2    Sesti, G.3
  • 20
    • 77956076972 scopus 로고    scopus 로고
    • Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents
    • Liraglutide Effect Action in Diabetes-6 Study Group.
    • Buse JB, Sesti G, Schmidt WE et al. Liraglutide Effect Action in Diabetes-6 Study Group. Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents. Diabetes Care 2010 33 (6 1300 3.
    • (2010) Diabetes Care , vol.33 , Issue.6 , pp. 1300-3
    • Buse, J.B.1    Sesti, G.2    Schmidt, W.E.3
  • 21
    • 0242269000 scopus 로고    scopus 로고
    • The treat-to-target trial: Randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    • Insulin Glargine 4002 Study Investigators.
    • Riddle MC, Rosenstock J, Gerich J Insulin Glargine 4002 Study Investigators. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care 2003 26 : 3080 6.
    • (2003) Diabetes Care , vol.26 , pp. 3080-6
    • Riddle, M.C.1    Rosenstock, J.2    Gerich, J.3
  • 22
    • 33845405222 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • ADOPT Study Group.
    • Kahn SE, Haffner SM, Heise MA et al. ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 2006 355 : 2427 43.
    • (2006) N Engl J Med , vol.355 , pp. 2427-43
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.