Rapid conditioning with oxygen oscillation: Neuroprotection by intermittent normobaric hyperoxia after transient focal cerebral ischemia in rats

Stroke

Volumn 43, Issue 1, 2012, Pages 220-226

  Liu, Changsuo ^a   Weaver, John ^a   Liu, Ke Jian ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

intermittent normobaric hyperoxia; neuroprotection; postconditioning

Indexed keywords

HYDROETHIDINE; PROTEIN KINASE B; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION SIZE; CONTROLLED STUDY; HYPEROXIA; INTERMITTENT NORMOBARIC HYPEROXIA; ISCHEMIC POSTCONDITIONING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OSCILLATION; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION; REPERFUSION INJURY; TRANSIENT FOCAL CEREBRAL ISCHEMIA; TRANSIENT ISCHEMIC ATTACK; WESTERN BLOTTING;

ANIMALS; BRAIN; HYPEROXIA; ISCHEMIC ATTACK, TRANSIENT; ISCHEMIC POSTCONDITIONING; MALE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES;

EID: 84855352328     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.625756     Document Type: Article

References (25)

1. Mathers CD, Boerma T, Ma Fat D. Global and regional causes of death. Br Med Bull. 2009;92:7-32.
2. Stinear C. Prediction of recovery of motor function after stroke. Lancet Neurol. 2010;9:1228-1232.
3. Aronowski J, Strong R, Grotta JC. Reperfusion injury: demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cereb Blood Flow Metab. 1997;17:1048-1056. (Pubitemid 27459332)
4. Zhao H, Sapolsky RM, Steinberg GK. Interrupting reperfusion as a stroke therapy: ischemic postconditioning reduces infarct size after focal ischemia in rats. J Cereb Blood Flow Metab. 2006;26:1114-1121. (Pubitemid 44268173)
5. Henninger N, Bouley J, Nelligan JM, Sicard KM, Fisher M. Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2007;27:1632-1642. (Pubitemid 47301449)
6. Kim HY, Singhal AB, Lo EH. Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia. Ann Neurol. 2005;57:571-575. (Pubitemid 40471171)
7. Liu S, Liu W, Ding W, Miyake M, Rosenberg GA, Liu KJ. Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2006;26: 1274-1284. (Pubitemid 44435242)
8. Singhal AB, Wang X, Sumii T, Mori T, Lo EH. Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab. 2002;22:861-868. (Pubitemid 34747603)
9. Liu S, Shi H, Liu W, Furuichi T, Timmins GS, Liu KJ. Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2004;24:343-349. (Pubitemid 38314590)
10. Sugawara T, Chan PH. Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal. 2003;5: 597-607. (Pubitemid 37315148)
11. Pignataro G, Meller R, Inoue K, Ordonez AN, Ashley MD, Xiong Z, et al. In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning. J Cereb Blood Flow Metab. 2008; 28:232-241. (Pubitemid 351161298)
12. Toker A, Newton AC. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J Biol Chem. 2000;275: 8271-8274. (Pubitemid 30180163)
13. Zhao H, Sapolsky RM, Steinberg GK. Phosphoinositide-3-kinase/akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol. 2006;34:249-270.
14. Gao X, Zhang H, Takahashi T, Hsieh J, Liao J, Steinberg GK, et al. The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways. J Neurochem. 2008;105:943-955. (Pubitemid 351562746)
15. Noshita N, Sugawara T, Lewén A, Hayashi T, Chan PH. Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice. Stroke. 2003;34:1513-1518. (Pubitemid 36693527)
16. Noshita N, Lewén A, Sugawara T, Chan PH. Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2001;21:1442-1450. (Pubitemid 33120944)
17. Zhao H, Shimohata T, Wang JQ, Sun G, Schaal DW, Sapolsky RM, et al. Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. J Neurosci. 2005;25:9794-9806. (Pubitemid 41510919)
18. Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994;269:5241-5248.
19. Gidday JM. Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci. 2006;7:437-448. (Pubitemid 44012284)
20. Hausenloy DJ, Tsang A, Mocanu MM, Yellon DM. Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol. 2005;288:H971-H976. (Pubitemid 40139686)
21. Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM. Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res. 2004;95:230-232. (Pubitemid 39056282)
22. Singhal AB, Dijkhuizen RM, Rosen BR, Lo EH. Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology. 2002;58:945-952. (Pubitemid 34242073)
23. Singhal AB, Ratai E, Benner T, Vangel M, Lee V, Koroshetz WJ, et al. Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke. Stroke. 2007;38:2851-2854. (Pubitemid 47494029)
24. Calvert JW, Zhang JH. Oxygen treatment restores energy status following experimental neonatal hypoxia-ischemia. Pediatr Crit Care Med. 2007; 8:165-173. (Pubitemid 46568567)
25. Stroke Therapy Academic Industrial Roundtable (STAIR). Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke. 1999;30:2752-2758.