Inhibition of Plk1 and Pin1 by 5'-nitro-indirubinoxime suppresses human lung cancer cells

Cancer Letters

Volumn 316, Issue 1, 2012, Pages 97-104

  Yoon, Hyo Eun ^a   Kim, Soo A ^b   Choi, Hong Seok ^a   Ahn, Mee Young ^a   Yoon, Jung Hoon ^a   Ahn, Sang Gun ^a  

^a Chosun University   (South Korea)

^b Dongguk University   (South Korea)

Author keywords

5' Nitro indirubinoxime (5' NIO); Cdk4; Lung cancer; Pin1; Plk1; Rb

Indexed keywords

5' NITRO INDIRUBINOXIME; ENZYME INHIBITOR; INDIRUBIN; INDIRUBIN 3' MONOXIME; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEPTIDYLPROLYL ISOMERASE PIN1; POLO LIKE KINASE 1; REGULATOR PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; INTRACELLULAR SIGNALING; LUNG CANCER; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CHICK EMBRYO; CYCLIN-DEPENDENT KINASE 4; G1 PHASE; HUMANS; INDOLES; LUNG NEOPLASMS; OXIMES; PEPTIDYLPROLYL ISOMERASE; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN; RNA, SMALL INTERFERING;

EID: 84855345843     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.10.029     Document Type: Article

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