γ-Glutamylcysteine inhibits oxidative stress in human endothelial cells

Life Sciences

Volumn 90, Issue 3-4, 2012, Pages 116-121

  Nakamura, Yukiko K ^a   Dubick, Michael A ^b   Omaye, Stanley T ^a  

^a UNIVERSITY OF NEVADA   (United States)

^b US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

Glutamylcysteine; Glutathione; Glutathione synthetase; Oxidative stress

Indexed keywords

GAMMA GLUTAMYLCYSTEINE; GLUTATHIONE; GLUTATHIONE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANTIOXIDANT ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; OXIDATIVE STRESS; PROTEIN BINDING;

EID: 84855331143     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.10.016     Document Type: Article

References (52)

1. Arab K, Rossary A, Flourie F, Tourneur Y, Steghens JP. Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating gamma-glutamylcycteinyl ligase and glutathione reductase. Br J Nutr 2006a;95(1):18-26. (Pubitemid 43250708)
2. Arab K, Rossary A, Soulere L, Steghens J. Conjugated linoleic acid, unlike other fatty acids, strongly induces glutathione sythesis without any lipoperoxidation. Br J Nutr 2006b;96:811-9. (Pubitemid 46454556)
3. Blount K, Breaker RR. Riboswitches as antibacterial drug targets. Nat Biotechnol 2006;24(12):1558-64. (Pubitemid 44967480)
4. Brasse-Lagnel C, Lavoinne AM, Husson AS. Amino acid regulation of mammalian gene expression in the intestine. Biochimie 2010;92(7):729-35.
5. Burge JA, Aust SD. Microsomal lipid peroxidation. Methods in Enzymology Colowick SP and Kaplan NO, 52. New York, USA: Academic Press, Inc.; 1978. p. 302-10.
6. Cao S, Zhang X, Edwards JP, Mosser DM. NF-κB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. J Biol Chem 2006;281 (36):26041-50. (Pubitemid 44401810)
7. Catani MV, Savini I, Duranti G, Capoross D, Ceci R, Sabatini S, Avigliano L. Nucelar factor κB and activating protein 1 are involved in differentiation-related resistance to oxidative stress in skeletal muscle cells. Free Radic Biol Med 2004;37(7):1024-36. (Pubitemid 39164584)
8. Chothe P, Singh N, Ganapathy V. Evidence for two different broad-specific oligopeptide transporters in the intestinal cell line Caco-2 and the colonic cell line CCD841. Am J Physiol Cell Physiol 2011;300(6):C1260-9.
9. Coeffier M, Dechelotte P. Combine infusion of glutamine and arginine: does it make sense? Curr Opin Clin Nutr Metab Care 2010;13:70-4.
10. Dringen R, Kranich O, Loschmann PA, Hamprecht B. Use of dipeptides for the synthesis of glutathione by astroglia-rich primary cultures. J Neurochem 1997;69(2): 868-74. (Pubitemid 27327992)
11. Dutton RP. Current concepts in hemorrhagic shock. Anesthesiol Clin 2007;25(1): 23-34. (Pubitemid 46497891)
12. Erdmann K, Cheung BWY, Schroder H. The possible roles of food-derived bioactove peptides in reducing the risk of cardiovascular disease. J Nutr Biochem 2008;19: 643-54.
13. Franco R, Schoneveld OJ, Pappa A, Panayiotidis MI. The central role of glutathione in the pathophysiology of human diseases. Arch Physiol Biochem 2007;113(4-5): 234-58.
14. Giustarini D, Milzani A, Dalle-Donne I, Rossi R. Red blood cells as a physiological source of glutathione for extracellular fluids. Blood Cells Mol Dis 2008;40:174-9. (Pubitemid 351221382)
15. Glantzounis GK, Yang W, Koti RS, Mikhailidis DP, Seifalian AM, Davidson BR. The role of thiols in liver ischemia-reperfusion injury. Curr Pharm Des 2006;12:2891-901. (Pubitemid 44184623)
16. Granger DN, Korthuis RJ. Physiologic mechanisms of postischemic tissue injury. Annu Rev Physiol 1995;57:311-32.
17. Grant CM, MacIver FH, Dawes IW. Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide γ-glutamylcysteine. Mol Biol Cell 1997;8:1699-707. (Pubitemid 27411135)
18. Hagenfeldt L, Arvidsson A, Larsson A. Glutathione and g-glutamylcysteine in whole blood, plasma and erythrocytes. Clin Chim Acta 1978;85:167-73. (Pubitemid 8308728)
19. Huang ZA, Yang H, Chen C, Zeng Z, Lu SC. Inducers of gamma- glutamylcysteine syntheatse and their effects on glutathione synthetase expression. Biochem Biophys Acta 2000;1493(1-2):48-55.
20. Huang ZZ, Chen C, Zeng Z, Yang H, Oh J, Chen L, Lu SC. Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration. FASEB J 2001;15(1):19-21.
21. Iwanaga M, Mori K, Iida T, Urata Y, Matsuo T, Yasunaga A, Shibata S, Kondo T. Nuclear factor kappa B dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells. Free Radic Biol Med 1998;24 (7-8):1256-68. (Pubitemid 28246741)
22. Komlosh A, Volohonsky G, Porat N, Tuby C, Bluvshtein E, Steinberg P, Oesch F, Stark AA. γ-Glutamyl transpeptidase and gulatathione biosynthesis in non-tumorigenic and tumorigenic rat liver oval cell lines. Carcinogenesis 2001;22(12):2009-16. (Pubitemid 34065397)
23. Krausz MM. Initial resuscitation of hemorrhagic shock. World J Emerg Surg 2006;1:14.
24. Kurozumi R, Kojima S. Increase of intracelluar glutathione by low-level NO mediated by transcription factor NF-kappaB in RAW 264.7 cells. Biochem Biophys Acta 2005;1744(1):58-67. (Pubitemid 40692678)
25. Lee TD, Yang H, Whang J, Lu SC. Cloning and characterization of the human glutathione sythetase 5′-flanking region. Biochem J 2005;390:521-8. (Pubitemid 41337114)
26. Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol 2002;282(2):C227-41. (Pubitemid 34663181)
27. Liu RM, Choi J. Age-associated decline in γ-glutamylcysteine synthetase gene expression in rats. Free Radic Biol Med 2000;28(4):566-74. (Pubitemid 30136038)
28. Matsui T, Sato M, Tanaka M, Yamada Y, Watanabe S, Fijimoto Y, Imaizumi K, Matsumoto K. Vasodilating dipeptide Trp-His can prevent atheroslcerosis in apoE-deficient mice. Br J Nutr 2010;103:309-13.
29. Matthews JR, Kaszubska W, Turcatti G, Wells TNC, Hay RT. Role of cycteine62 in DNA recognition by the p50 subunit of NF-kappaB. Nucleic Acids Res 1993;21(8): 1727-34. (Pubitemid 23178885)
30. Muller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC. Structure of the NF-kappaB p50 homodimer bound to DNA. Nature 1995;373(6512):311-7.
31. Murakami S, Kurihara S, Koikawa N, Nakamura A, Aoki K, Yosigi H, Sawaki K, Ohtani M. Effects of oral supplementation with cystine and theanine on the immune function of atheletes in endurance exercise: randomized, double-blind, placebo-controlled trial. Biosci Biotechnol Biochem 2009;73(4):817-21.
32. Nakamura YK, Omaye ST. Vitamin E-modulated gene expression associated with ROS generation. J Funct Foods 2009;1:241-52.
33. Nefedova Y, Fishman M, Sherman S, Wang X, Beg AA, Gabrilovich DI. Mechanism of alltrans retinoic acid effect on tumor-associated myeloid-derived supressor cells. Cancer Res 2007;67(22):11021-8. (Pubitemid 350145932)
34. Okuno Y, Matsuda M, Miyata Y, Fukuhara A, Komoro R, Shimabukuro M, Shimomura I. Human catalase gene is regulated by peroxisome proliferator- activated receptorgamma through a response element distinct from that of mouse. Endocr J 2010;57(4):303-9.
35. Ray PS, Jia J, Yao P, Majumder M, Hatzoglou M, Fox PL. A stress-responsive RNA switch regulates VEGFA expression. Nature 2009;457:915-20.
36. Ringseis R, Gotze V, Eder K. Tripeptides from dietary proteins inhibit TNFalpha-induced monocyte adhesion to human aortic endothelial cells. Regul Pept 2009;154(1-3): 91-6.
37. Ristoff E, Hebert C, Njalsson R, Norgren S, Rooyackers O, Larsson A. Glutathione synthetase deficiency: Is γ-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione? J Inherit Metab Disord 2002;25:577-84. (Pubitemid 36266993)
38. Roberts PR, Burney JD, Black KW, Zaloga GP. Effect of chain length on absorption of biologically active peptides from the gastrointestinal tract. Digestion 1999;60:332-7. (Pubitemid 29292229)
39. Rubio-Aliaga I, Frey I, Boll M, Groneberg DA, Eichinger HM, Balling R, Daniel H. Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney. Mol Cell Biol 2003;23(9):3247-52. (Pubitemid 36459237)
40. Sato N, Moore FA, Kone BC, Zou L, Smith MA, Childs MA, Moore-Olufemi S, Scheultz SG, Kozar RA. Differential induction of PPAR-γ by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel. Am J Physiol Gastrointest Liver Physiol 2006;290:G616-23.
41. Smith AM, Fuchs RT, Grundy FJ, Henkin TM. Riboswitch RNAs: regulation of gene expression by direct monitoring of a physiological signal. RNA Biol 2010;7(1): 104-10.
42. Takagi Y, Kurihara S, Higashi N, Morikawa S, Kase T, Maeda A, Arisaka H, Shibahara S, Akiyama Y. Combined administration of L-cystine and L-theanine enhances immune functions and protects against influenza virus infection in aged mice. Immunology 2010;72(2):157-65.
43. Tchantchou F, Graves M, Ashline D, Morin A, Pimenta A, Ortiz D, Rogers E, Shea TB. Increased transcription and activity of glutathione synthetase in response to deficiencies in folate, vitamin E, and apolipoprotein E. J Neurosci Res 2004;75:508-15. (Pubitemid 38160712)
44. Vincent HK, Innes KE, Vincent KR. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab 2007;9: 813-39. (Pubitemid 47555204)
45. White CR, Datta G, Mochon P, Zhang Z, Kelly O, Curcio C, Parks D, Palgunachari M, Handattu S, Gupta H, Garber DW, Anantharamaiah GM. Vasculoprotective effects of apolipoprotein mimetic peptides: an evolving paradigm in HDL therapy (Vascular disease prevention, In Press). Vasc Dis Prev 2009;6:122-30.
46. Wu G. Amino acids: metabolism, functions, and nutrition. Amino Acids 2009;37:1-17.
47. Wu G, Fang Y, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 2004;134:489-92. (Pubitemid 38298485)
48. Xu L, Sun J, Lu R, Ji Q, Xu J. Effect of glutamate on inflammatory responses of intestine and brain after focal cerebral ischemia. World J Gastroenterol 2005;11(5):733-6. (Pubitemid 40220769)
49. Yang H, Magilnick N, Ou X, Lu SC. Tumour necrosis factor alpha induces coordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1. Biochem J 2005;391(Pt 2):399-408. (Pubitemid 41532438)
50. Zeevalk GD, Razmpour R, Bernard LP. Glutathione and Parkinson's disease: is this the elephant in the room? Biomed Pharmacother 2008;62:230-49.
51. Zhou J, Liu W, Pong RC, Hao G, Sun X, Hsieh JT. Analysis of oligo-arginine cellpermeable peptides uptake by prostate cells. Amino Acids in press, doi:10.1007/s00726-010-0817-7.
52. Zhu Y, Carvey PM, Ling Z. Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res 2006;1090(1):35-44