Combined administration of L-cystine and L-theanine enhances immune functions and protects against influenza virus infection in aged mice

Journal of Veterinary Medical Science

Volumn 72, Issue 2, 2010, Pages 157-165

  Takagi, Yasuhiro ^a,d   Kurihara, Shigekazu ^b   Higashi, Natsumi ^a   Morikawa, Saeko ^a   Kase, Tetsuo ^a   Maeda, Akiko ^c   Arisaka, Harumi ^b   Shibahara, Susumu ^b   Akiyama, Yukio ^b,e  

^a OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^b AJINOMOTO CO INC   (Japan)

^c Osaka Prefecture University   (Japan)

^d OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^e NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Aged mice; Antibody production; Cystine; Influenza virus infection; Theanine

Indexed keywords

CYSTINE; GLUTAMIC ACID DERIVATIVE; GLUTATHIONE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; THEANINE; VIRUS ANTIBODY;

AGING; ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; C3H MOUSE; FEMALE; GERMFREE ANIMAL; IMMUNOLOGY; INFLUENZA VIRUS A H3N2; LUNG; MOUSE; NONPARAMETRIC TEST; ORTHOMYXOVIRUS INFECTION; VIROLOGY;

AGING; ANIMALS; ANTIBODIES, VIRAL; CYSTINE; FEMALE; GLUTAMATES; GLUTATHIONE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INFLUENZA A VIRUS, H3N2 SUBTYPE; LUNG; MICE; MICE, INBRED C3H; ORTHOMYXOVIRIDAE INFECTIONS; SPECIFIC PATHOGEN-FREE ORGANISMS; STATISTICS, NONPARAMETRIC;

MUS; ORTHOMYXOVIRIDAE;

EID: 77649306385     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.09-0067     Document Type: Article

References (36)

1. Bender, B. S., Bell, W. E., Taylor, S. and Small, P. A. Jr. 1994. Class I major histocompatibility complex-restricted cytotoxic T lymphocytes are not necessary for heterotypic immunity to influenza. J. Infect. Dis. 170: 1195-1200.
2. Bukowski, J. F., Morita, C. T. and Brenner, M. B. 1999. Human γδ T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity. Immunity 11: 57-65.
3. Cox, R. J., Brokstad, K. A. and Ogra, P. 2004. Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines. Scand. J. Immunol. 59: 1-15.
4. Dröge, W., Grob, A., Hack, V., Kinscherf, R., Schykowski, M., Bockstette, M., Mihm, S. and Galter, D. 1997. Antioxidants in Disease Mechanisms and Therapeutic Strategies. pp. 581-600. In: Adv Pharmacol, vol. 38. (Sies, H. ed.), Academic Press, New York.
5. Dröge, W., Hack, V., Breitkreutz, R., Holms, E., Shubinsky, G., Schmit, E. and Galter, D. 1998. Role of cysteine and glutathione in signal transduction, immunopathology and cachexia. Biofactors 8: 97-102.
6. Eichelberger, M., Allan, W., Zijlstra, M., Jaenisch, R. and Doherty, P. C. 1991. Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J. Exp. Med. 174: 875-880.
7. Ferrari, C. K. and Torres, E. A. 2003. Biochemical pharmacology of functional foods and prevention of chronic diseases of aging. Biomed. Pharmacother. 57: 251-260.
8. Franklin, R. A., Li, Y. M., Arkins, S. and Kelley, K. W. 1990. Glutathione augments in vitro proliferative responses of lymphocytes to concanavalin A to a greater degree in old than in young rats. J. Nutr. 120: 1710-1717.
9. Fuente, M. D. L. 2002. Effects of antioxidants on immune system ageing. Eur. J. Clin. Nutr. 56: S5-8.
10. Fujisawa, H. 2001. Inhibitory role of neutrophils on influenza virus multiplication in the lungs of mice. Microbiol. Immunol. 45: 679-688.
11. Furukawa, T., Meydani, S. N. and Blumberg, J. B. 1987. Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice. Mech. Aging Dev. 38: 107-117.
12. Ginaldi, L., DeMartinis, M., D'Ostilio, A., Marina, L., Loreto, M. F. and Quaglino, D. 1999. The immune system in the elderly: II. Specific cellular immunity. Immunol. Res. 20: 109-115.
13. Glezen, W. P. 1982. Serious morbidity and mortality associated with influenza epidemics. Epidemiol. Rev. 4: 25-44.
14. Gosset, P., Wallaert, B., Tonnel, A. and Fourneau, C. 1999. Thiol regulation of the production TNF-alpha, IL-6 and IL-8 by human alveolar macrophages. Eur. Respir. J. 14: 98-105.
15. Hack, V., Schmid, D., Breitkreutz, R., Stahl-Henning, C., Drings, P., Kinscherf, H., Taut, F., Holm, E. and Dröge, W. 1997. Cystine levels, cystine flux, and protein catabolism in cancer cachexia, HIV/SIV infection, and senescence. FASEB J. 11: 84-92.
16. Hayek, M. G., Taylor, S. F., Bender, B. S., Han, S. N., Meydani, M., Smith, D. E., Eqhtesada, S. and Meydani, S. N. 1997. Vitamin E supplementation decreases lung virus titers in mice infected with influenza. J. Infect. Dis. 176: 273-276.
17. Heidrick, M. L., Albright, J. W. and Makinodan, T. 1980. Restoration of impaired immune functions in aging animals. IV. Action of 2-mercaptoethanol in enhancing age-reduced immune responsiveness. Mech. Aging Dev. 13: 367-378.
18. Hennet, T., Peterhans, E. and Stocker, R. 1992. Alterations in antioxidant defences in lung and liver of mice infected with influenza A virus. J. Gen. Virol. 73: 39-46.
19. Kajimura, K., Takagi, Y., Miyano, K., Sawabe, Y., Mimura, M., Sakagami, Y., Yokoyama, H. and Yoneda, K. 1997. Polysaccharide of Astragali radix enhances IgM antibody production in aged mice. Biol. Pharm. Bull. 20: 1178-1182.
20. Kamath, A. B., Wang, L., Das, H., Li, L., Reinhold, V. N. and Bukowski, J. F. 2003. Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proc. Natl. Acad. Sci. U.S.A. 100: 6009-6014.
21. Kilbourne, E. D. 1987. pp. 157-218. Influenza in man. In: Influenza (Kilbourne, E. D. ed.), Plenum Medical Book Company, New York.
22. Kurihara, S., Shibahara, S., Arisaka, H. and Akiyama, Y. 2007. Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine. J. Vet. Med. Sci. 69: 1263-1270.
23. Lee, F. E., Walsh, E. E., Falsey, A. R., Liu, D., Divekar, A., Snyder-Cappione, J. E. and Mosmann, T. R. 2005. The balance between influenza-and RSV-specific CD4 T cells secreting IL-10 or IFNgamma in young and healthy-elderly subjects. Mech. Aging Dev. 126: 1223-1229.
24. Liu, R. and Choi, J. 2000. Age-associated decline in γ-glutamylcysteine synthetase gene expression in rats. Free Rad. Biol. Med. 28: 566-574.
25. Maeda, H. and Akaike, T. 1991. Oxygen free radicals as pathogenic molecules in viral diseases. Proc. Soc. Exp. Biol. Med. 198: 721-727.
26. Oda, T., Akaike, T., Hamamoto, T., Suzuki, F., Hirano, T. and Maeda, H. 1989. Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD. Science 244: 974-976.
27. Palladino, G., Mozdzanowska, K., Washko, G. and Gerhard, W. 1995. Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J. Virol. 69: 2075-2081.
28. Pawelec, G., Effros, C., Caruso, C., Remarque, E., Barnett, Y. and Solana, R. 1999. T cells and aging (update February 1999). Front. Biosci. 4: 216-269.
29. Pena, L., Hill, D. and MaClain, C. 1999. Treatment with glutathione precursor decreases cytokine activity. J. Parenter. Enteral. Nutr. 23: 1-6.
30. Powers, D. C. and Belshe, R. B. 1993. Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine. J. Infect. Dis. 167: 584-592.
31. Rahman, I. and MacNee, W. 2000. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic. Biol. Med. 28: 1405-1420.
32. Rimaniol, A., Mialocq, P., Clayette, P., Dormont, D. and Gras, G. 2001. Role of glutamate transporters in the regulation of glutathione levels in human macrophages. Am. J. Physiol. Cell Physiol. 281: 1964-1970.
33. Rozen, S. and Skaletsky, H. 2000. pp. 365-386. Methods in Molecular Biology. In: Bioinformatics Methods and Protocols (Krawetz, S. and Misener, S. eds.), Humana Press, Totowa.
34. Spellberg, B. and Edwards, J. E. Jr. 2001. Type 1/Type 2 immunity in infectious diseases. Clin. Infect. Dis. 32: 76-102.
35. Takagi, Y., Higashi, N., Kawai, S., Maeda, A. and Ueba, N. 2004. Effects of traditional oriental medicine on influenza virus infection: activating effect of Mao-Bushi-Saishin-To (MBST, Ma-Huang-Fu-Zi-Xin-Tang) on IgG antibody producibility in aged mice. Int. Congr. Ser. 1263: 670-673.
36. Wouters-Wesseling, W., Rozendaal, M., Snijder, M., Graus, Y., Rimmelzwaan, G., De Groot, L. and Bindels, J. 2002. Effect of a complete nutritional supplement on antibody response to influenza vaccine in elderly people. J. Gerontol. A Biol. Sci. Med. Sci. 57: M563-566.