Replication of the SH2B1 rs7498665 association with obesity in a Belgian study population

Obesity Facts

Volumn 4, Issue 6, 2011, Pages 473-477

  Beckers, Sigri ^a   Zegers, Doreen ^a   Van Gaal, Luc F ^b   Van Hul, Wim ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Association study; Obesity; SH2B1

Indexed keywords

GENOMIC DNA; PROTEIN SH2; SRC HOMOLOGY 2 B ADAPTOR PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; BELGIUM; CASE CONTROL STUDY; CAUCASIAN; CONTROLLED STUDY; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HAPLOTYPE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; OBESITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; ALLELES; BELGIUM; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; OBESITY; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES;

EID: 84855316813     PISSN: 16624025     EISSN: 16624033     Source Type: Journal    
DOI: 10.1159/000335305     Document Type: Article

References (31)

1. Willer CJ, Speliotes EK, Loos RJ, et al.: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
2. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I, Jonsdottir T, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Jonsson F, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Lauritzen T, Aben KK, Verbeek AL, Roeleveld N, Kampman E, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Becker DM, Gulcher J, Kiemeney LA, Pedersen O, Kong A, Thorsteinsdottir U, Stefansson K: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009;41:18-24.
3. Rui L, Mathews LS, Hotta K, Gustafson TA, Carter-Su C: Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling. Mol Cell Biol 1997;17:6633-6644. (Pubitemid 27451210)
4. Duan C, Li M, Rui L: SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem 2004;279:43684-43691. (Pubitemid 39390672)
5. Li Z, Zhou Y, Carter-Su C, Myers MG Jr, Rui L: SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms. Mol Endocrinol 2007; 21:2270-2281. (Pubitemid 47347387)
6. Morris DL, Cho KW, Zhou Y, Rui L: Sh2b1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins. Diabetes 2009;58:2039-2047.
7. Duan C, Yang H, White MF, Rui L: Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol 2004;24:7435-7443. (Pubitemid 39121472)
8. Ren D, Li M, Duan C, Rui L: Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab 2005;2:95-104.
9. Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L: Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest 2007;117:397-406. (Pubitemid 46203968)
10. Jamshidi Y, Snieder H, Ge D, Spector TD, O'Dell SD: The SH2B gene is associated with serum leptin and body fat in normal female twins. Obesity (Silver Spring) 2007;15:5-9. (Pubitemid 46219777)
11. Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, Saeed S, Hamilton-Shield J, Clayton-Smith J, O'Rahilly S, Hurles ME, Farooqi IS: Large, rare chromosomal deletions associated with severe early-onset obesity. Nature; 463:666-670.
12. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
13. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D: Efficiency and power in genetic association studies. Nat Genet 2005;37: 1217-1223. (Pubitemid 41568704)
14. International HapMap Project, www.hapmap.org, accessed on 14 July 2009.
15. Ott J: Documentation to LINKAGE UTILITY programs, http://linkage. rockefeller.edu/ott/linkutil.htm, accessed on 15 December 2009.
16. Gauderman WJ, Morrison JM: QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies, http://hydra.usc.edu/ gxe, accessed on 15 December 2009.
17. Benjamini Y, Hochberg Y: Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing. Journal of the Royal Statistical Society Series B-Methodological 1995;57:289-300.
18. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894. (Pubitemid 46764279)
19. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orru M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder AB, Cooper RS, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis GR: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007;3:e115.
20. Dina C, Meyre D, Gallina S, Durand E, Korner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougneres P, Kovacs P, Marre M, Balkau B, Cauchi S, Chevre JC, Froguel P: Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-726. (Pubitemid 46848595)
21. Loos RJ, Lindgren CM, Li S, Wheeler E, et al.: Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008;40:768-775.
22. Lindgren CM, Heid IM, Randall JC, et al.: Genome- wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009;5:e1000508.
23. Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, Gallina S, Durand E, Vatin V, Degraeve F, Proenca C, Gaget S, Korner A, Kovacs P, Kiess W, Tichet J, Marre M, Hartikainen AL, Horber F, Potoczna N, Hercberg S, Levy-Marchal C, Pattou F, Heude B, Tauber M, McCarthy MI, Blakemore AI, Montpetit A, Polychronakos C, Weill J, Coin LJ, Asher J, Elliott P, Jarvelin MR, Visvikis-Siest S, Balkau B, Sladek R, Balding D, Walley A, Dina C, Froguel P: Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 2009;41:157-159.
24. Loos RJ, Bouchard C: FTO: the first gene contributing to common forms of human obesity. Obes Rev 2008;9:246-250. (Pubitemid 351550693)
25. Heard-Costa NL, Zillikens MC, Monda KL, et al.: NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS Genet 2009;5:e1000539.
26. Zobel DP, Andreasen CH, Grarup N, Eiberg H, Sorensen TI, Sandbaek A, Lauritzen T, Borch- Johnsen K, Jorgensen T, Pedersen O, Hansen T: Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes. Diabetes 2009;58:757-764.
27. Renstrom F, Payne F, Nordstrom A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordstrom P, Franks PW: Replication and extension of genomewide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 2009;18:1489-1496.
28. Tenesa A, Campbell H, Theodoratou E, Dunlop L, Cetnarskyj R, Farrington SM, Dunlop MG: Common genetic variants at the MC4R locus are associated with obesity, but not with dietary energy intake or colorectal cancer in the Scottish population. Int J Obes (Lond) 2009;33:284-288.
29. Peeters A, Beckers S, Verrijken A, Roevens P, Peeters P, Van Gaal L, Van Hul W: Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 2008;93: 481-484. (Pubitemid 351381467)
30. Beckers S, Zegers D, de Freitas F, Mertens IL, Van Gaal LF, Van Hul W: Association study of mc4r with complex obesity and replication of the rs17782313 association signal. Mol Genet Metab 2011;103:71-75.
31. Speliotes EK, Willer CJ, Berndt SI, et al.: Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010;42:937-948.