Variations in helicobacter pylori cytotoxin-associated genes and their influence in progression to gastric cancer: Implications for prevention

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Rizzato, Cosmeri ^a   Torres, Javier ^b   Plummer, Martyn ^c   Muñoz, Nubia ^d   Franceschi, Silvia ^c   Camorlinga Ponce, Margarita ^b   Fuentes Pananá, Ezequiel M ^b   Canzian, Federico ^a   Kato, Ikuko ^e  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^d Instituto Nacional de Cancerología   (Colombia)

^e WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CAG GAMMA GENE; CAGA GENE; CAGC GENE; CAGE GENE; CAGL GENE; CAGT GENE; CAGV GENE; CANCER GROWTH; CHRONIC GASTRITIS; CODON; CONTROLLED STUDY; CYTOTOXIN ASSOCIATED GENE; CYTOTOXIN ASSOCIATED GENE PATHOGENICITY ISLAND; DNA EXTRACTION; FEMALE; GENETIC VARIABILITY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MEXICO; NONHUMAN; NUCLEOTIDE SEQUENCE; PYROSEQUENCING; RHIZOBIUM; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH BIOPSY; STOMACH CANCER; VENEZUELA; DISEASE COURSE; GENETICS; GENOMIC ISLAND; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; RISK; STOMACH TUMOR; VIRUS GENE;

AGROBACTERIUM; BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

ADULT; AGED; DISEASE PROGRESSION; FEMALE; GENES, VIRAL; GENETIC VARIATION; GENOMIC ISLANDS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; RISK; STOMACH NEOPLASMS;

EID: 84855315700     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029605     Document Type: Article

References (55)

1. Parkin DM, (2006) The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118: 3030-3044.
2. Suerbaum S, Michetti P, (2002) Helicobacter pylori infection. N Engl J Med 347: 1175-1186.
3. Compare D, Rocco A, Nardone G, (2010) Risk factors in gastric cancer. Eur Rev Med Pharmacol Sci 14: 302-308.
4. Kim SS, Ruiz VE, Carroll JD, Moss SF, (2010) Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma. Cancer Lett 305: 228-238.
5. Wroblewski LE, Peek RM Jr, Wilson KT, (2010) Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev 23: 713-739.
6. Plummer M, van Doorn LJ, Franceschi S, Kleter B, Canzian F, et al. (2007) Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions. J Natl Cancer Inst 99: 1328-1334.
7. Azuma T, Yamakawa A, Yamazaki S, Fukuta K, Ohtani M, et al. (2002) Correlation between variation of the 3′ region of the cagA gene in Helicobacter pylori and disease outcome in Japan. J Infect Dis 186: 1621-1630.
8. Yamaoka Y, El-Zimaity HM, Gutierrez O, Figura N, Kim JG, et al. (1999) Relationship between the cagA 3′ repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH. Gastroenterology 117: 342-349.
9. Backert S, Selbach M, (2008) Role of type IV secretion in Helicobacter pylori pathogenesis. Cell Microbiol 10: 1573-1581.
10. El-Etr SH, Mueller A, Tompkins LS, Falkow S, Merrell DS, (2004) Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers. J Infect Dis 190: 1516-1523.
11. Hatakeyama M, (2006) Helicobacter pylori CagA-- a bacterial intruder conspiring gastric carcinogenesis. Int J Cancer 119: 1217-1223.
12. Peek RM Jr, Crabtree JE, (2006) Helicobacter infection and gastric neoplasia. J Pathol 208: 233-248.
13. Romano M, Ricci V, Zarrilli R, (2006) Mechanisms of disease: Helicobacter pylori-related gastric carcinogenesis--implications for chemoprevention. Nat Clin Pract Gastroenterol Hepatol 3: 622-632.
14. Basso D, Zambon CF, Letley DP, Stranges A, Marchet A, et al. (2008) Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. Gastroenterology 135: 91-99.
15. Reyes-Leon A, Atherton JC, Argent RH, Puente JL, Torres J, (2007) Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene. Infect Immun 75: 3445-3454.
16. Olbermann P, Josenhans C, Moodley Y, Uhr M, Stamer C, et al. (2010) A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island. PLoS Genet 6: e1001069.
17. Plummer M, Vivas J, Lopez G, Bravo JC, Peraza S, et al. (2007) Chemoprevention of precancerous gastric lesions with antioxidant vitamin supplementation: a randomized trial in a high-risk population. J Natl Cancer Inst 99: 137-146.
18. Munoz N, Vivas J, Buiatti E, Kato I, Oliver W, (1996) Chemoprevention trial on precancerous lesions of the stomach in Venezuela: summary of study design and baseline data. IARC Sci Publ pp. 125-133.
19. Clabots CR, Johnson S, Bettin KM, Mathie PA, Mulligan ME, et al. (1993) Development of a rapid and efficient restriction endonuclease analysis typing system for Clostridium difficile and correlation with other typing systems. J Clin Microbiol 31: 1870-1875.
20. Argent RH, Thomas RJ, Aviles-Jimenez F, Letley DP, Limb MC, et al. (2008) Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families. Clin Cancer Res 14: 2227-2235.
21. Rudi J, Kolb C, Maiwald M, Kuck D, Sieg A, et al. (1998) Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases. J Clin Microbiol 36: 944-948.
22. Alm RA, Ling LS, Moir DT, King BL, Brown ED, et al. (1999) Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 397: 176-180.
23. Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, et al. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388: 539-547.
24. Baltrus DA, Amieva MR, Covacci A, Lowe TM, Merrell DS, et al. (2009) The Complete Genome Sequence of Helicobacter pylori Strain G27. J Bacteriol 191: 447-448.
25. Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, et al. (1996) cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci U S A 93: 14648-14653.
26. Tegtmeyer N, Wessler S, Backert S, (2011) Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J 278: 1190-1202.
27. Terradot L, Waksman G, (2011) Architecture of the Helicobacter pylori Cag-type IV secretion system. FEBS J 278: 1213-1222.
28. Zahrl D, Wagner M, Bischof K, Bayer M, Zavecz B, et al. (2005) Peptidoglycan degradation by specialized lytic transglycosylases associated with type III and type IV secretion systems. Microbiology 151: 3455-3467.
29. Batista SA, Rocha GA, Rocha AM, Saraiva IE, Cabral MM, et al. (2011) Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer. BMC Microbiol 11: 61.
30. Sicinschi LA, Correa P, Peek RM, Camargo MC, Piazuelo MB, et al. (2010) CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. Clin Microbiol Infect 16: 369-378.
31. Acosta N, Quiroga A, Delgado P, Bravo MM, Jaramillo C, (2010) Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis. World J Gastroenterol 16: 3936-3943.
32. Choi KD, Kim N, Lee DH, Kim JM, Kim JS, et al. (2007) Analysis of the 3′ variable region of the cagA gene of Helicobacter pylori isolated in Koreans. Dig Dis Sci 52: 960-966.
33. Higashi H, Yokoyama K, Fujii Y, Ren S, Yuasa H, et al. (2005) EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells. J Biol Chem 280: 23130-23137.
34. Ren S, Higashi H, Lu H, Azuma T, Hatakeyama M, (2006) Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells. J Biol Chem 281: 32344-32352.
35. Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, et al. (2007) Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 447: 330-333.
36. Suzuki M, Mimuro H, Kiga K, Fukumatsu M, Ishijima N, et al. (2009) Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation. Cell Host Microbe 5: 23-34.
37. Buti L, Spooner E, Van der Veen AG, Rappuoli R, Covacci A, et al. (2011) Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proc Natl Acad Sci U S A 108: 9238-9243.
38. Kutter S, Buhrdorf R, Haas J, Schneider-Brachert W, Haas R, et al. (2008) Protein Subassemblies of the Helicobacter pylori Cag Type IV Secretion System Revealed by Localization and Interaction Studies. J Bacteriol 190: 2161-2171.
39. Baron C, (2006) VirB8: a conserved type IV secretion system assembly factor and drug target. Biochem Cell Biol 84: 890-899.
40. Kerr JE, Christie PJ, (2010) Evidence for VirB4-mediated dislocation of membrane-integrated VirB2 pilin during biogenesis of the Agrobacterium VirB/VirD4 type IV secretion system. J Bacteriol 192: 4923-4934.
41. Argent RH, Thomas RJ, Letley DP, Rittig MG, Hardie KR, et al. (2008) Functional association between the Helicobacter pylori virulence factors VacA and CagA. J Med Microbiol 57: 145-150.
42. Hofman V, Ricci V, Galmiche A, Brest P, Auberger P, et al. (2000) Effect of Helicobacter pylori on polymorphonuclear leukocyte migration across polarized T84 epithelial cell monolayers: role of vacuolating toxin VacA and cag pathogenicity island. Infect Immun 68: 5225-5233.
43. Sieveking D, Mitchell HM, Day AS, (2004) Gastric epithelial cell CXC chemokine secretion following Helicobacter pylori infection in vitro. J Gastroenterol Hepatol 19: 982-987.
44. Grantham R, Gautier C, Gouy M, Mercier R, Pave A, (1980) Codon catalog usage and the genome hypothesis. Nucleic Acids Res 8: r49-r62.
45. Gouy M, Gautier C, (1982) Codon usage in bacteria: correlation with gene expressivity. Nucleic Acids Research 10: 7055-7074.
46. Post LE, Nomura M, (1980) DNA sequences from the str operon of Escherichia coli. Journal of Biological Chemistry 255: 4660-4666.
47. Kudla G, Murray AW, Tollervey D, Plotkin JB, (2009) Coding-Sequence Determinants of Gene Expression in Escherichia coli. Science 324: 255-258.
48. Lafay B, Atherton JC, Sharp PM, (2000) Absence of translationally selected synonymous codon usage bias in Helicobacter pylori. Microbiology 146 (Pt 4): 851-860.
49. Kloster M, Tang C, (2008) SCUMBLE: a method for systematic and accurate detection of codon usage bias by maximum likelihood estimation. Nucleic Acids Res 36: 3819-3827.
50. Kwok T, Zabler D, Urman S, Rohde M, Hartig R, et al. (2007) Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 449: 862-866.
51. Peek RM Jr, Fiske C, Wilson KT, (2010) Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Physiol Rev 90: 831-858.
52. Saha A, Backert S, Hammond CE, Gooz M, Smolka AJ, (2010) Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology 139: 239-248.
53. Yeh YC, Chang WL, Yang HB, Cheng HC, Wu JJ, et al. (2011) H. pylori cagL amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin alpha5beta1 related with gastric carcinogenesis. Mol Carcinog 50: 751-759.
54. Zhong Q, Shao S, Mu R, Wang H, Huang S, et al. (2011) Characterization of peptidoglycan hydrolase in Cag pathogenicity island of Helicobacter pylori. Mol Biol Rep 38: 503-509.
55. Konturek PC, Konturek SJ, Brzozowski T, (2009) Helicobacter pylori infection in gastric cancerogenesis. J Physiol Pharmacol 60: 3-21.