Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 22, 2011, Pages 9238-9243

  Buti, Ludovico ^a,b   Spooner, Eric ^a   Van Der Veen, Annemarthe G ^a   Rappuoli, Rino ^b   Covacci, Antonello ^b   Ploegh, Hidde L ^a,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Microbial pathogenesis; Type IV secretion

Indexed keywords

APOPTOSIS STIMULATING PROTEIN OF P53; BACTERIAL PROTEIN; CAGA PROTEIN; CASPASE 3; DOXORUBICIN; PROTEASOME; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CANCER RISK; CARBOXY TERMINAL SEQUENCE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOWN REGULATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOST; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; STOMACH CANCER; TIGHT JUNCTION;

AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BACTERIAL PROTEINS; DNA; DOXORUBICIN; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HELICOBACTER PYLORI; HUMANS; MOLECULAR SEQUENCE DATA; PHENOTYPE; RISK; STOMACH NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI; MUS;

EID: 79959355340     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106200108     Document Type: Article

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