Identification of cellular factors binding to acetylated HIV-1 integrase

Amino Acids

Volumn 41, Issue 5, 2011, Pages 1137-1145

  Allouch, Awatef ^a   Cereseto, Anna ^a  

^a SCUOLA NORMALE SUPERIORE   (Italy)

Author keywords

Acetylation; Histones acetyltransferase; HIV 1 integrase; Integrase binding factors; Tethered catalysis system; Yeast two hybrid screening

Indexed keywords

BASIC TRANSCRIPTION FACTOR 3; COILED COIL DOMAIN CONTAINING 32 ISOFORM1; ELONGATION FACTOR 1ALPHA; EUKARYOTIC TRNSLATION INITIATION FACTOR 3 SUBUNIT; EXPORTIN 2; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A2; HIGH MOBILITY GROUP NUCLEOSOMAL BINDING DOMAIN 2; HOST FACTOR; INITIATION FACTOR; INTEGRASE; ISOPROTEIN; KRUPPEL ASSOCIATED PROTEIN 1; LENS EPITHELIUM DERIVED GROWTH FACTOR; NUCLEAR PROTEIN; PROTEIN P300; RAN BINDING PROTEIN 9; RIBOSOMAL PROTEIN L23; STATHMIN; STATHMIN 1; THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR PROTEIN 3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BINDING AFFINITY; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME REGULATION; GENE SEQUENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROTUBULE ORGANIZING CENTER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RNA BINDING; TWO HYBRID SYSTEM; VIRUS CELL INTERACTION; VIRUS REPLICATION;

ACETYLATION; CELL LINE; HIV INFECTIONS; HIV INTEGRASE; HIV-1; HOST-DERIVED CELLULAR FACTORS; HUMANS; PROTEIN BINDING; PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84855226549     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-009-0444-3     Document Type: Article

References (51)

1. Albanese A, Arosio D, Terreni M, Cereseto A (2008) HIV-1 preintegration complexes selectively target decondensed chromatin in the nuclear periphery. PLoS One 3:e2413
2. Berchtold MW, Berger MC (1991) Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein. Gene 102:283-288
3. Bouyac-Bertoia M, Dvorin JD, Fouchier RA, Jenkins Y, Meyer BE, Wu LI, Emerman M, Malim MH (2001) HIV-1 infection requires a functional integrase NLS. Mol Cell 7:1025-1035 (Pubitemid 32525749)
4. Bushman F, Lewinski M, Ciuffi A, Barr S, Leipzig J, Hannenhalli S, Hoffmann C (2005) Genome-wide analysis of retroviral DNA integration. Nat Rev Microbiol 3:848-858 (Pubitemid 41693180)
5. Bustin M (2001) Chromatin unfolding and activation by HMGN(*) chromosomal proteins. Trends Biochem Sci 26:431-437 (Pubitemid 32607485)
6. Calado A, Treichel N, Muller EC, Otto A, Kutay U (2002) Exportin- 5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J 21:6216-6224 (Pubitemid 35415338)
7. Cassimeris L (2002) The oncoprotein 18/stathmin family of microtubule destabilizers. Curr Opin Cell Biol 14:18-24 (Pubitemid 34131652)
8. Cereseto A, Manganaro L, Gutierrez MI, Terreni M, Fittipaldi A, Lusic M, Marcello A, Giacca M (2005) Acetylation of HIV-1 integrase by p300 regulates viral integration. EMBO J 24:3070-3081 (Pubitemid 41486343)
9. Cherepanov P, Maertens G, Proost P, Devreese B, Van Beeumen J, Engelborghs Y, De Clercq E, Debyser Z (2003) HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J Biol Chem 278:372-381 (Pubitemid 36043586)
10. Christ F, Thys W, De Rijck J, Gijsbers R, Albanese A, Arosio D, Emiliani S, Rain JC, Benarous R, Cereseto A et al (2008) Transportin-SR2 imports HIV into the nucleus. Curr Biol 18:1192-1202
11. Cimarelli A, Luban J (1999) Translation elongation factor 1-alpha interacts specifically with the human immunodeficiency virus type 1 Gag polyprotein. J Virol 73:5388-5401 (Pubitemid 29274821)
12. Ciuffi A, Llano M, Poeschla E, Hoffmann C, Leipzig J, Shinn P, Ecker JR, Bushman F (2005) A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med 11:1287-1289 (Pubitemid 41752906)
13. Coffin JM, Hughes SH, Varmus HE (1997) Retroviruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
14. de Soultrait VR, Caumont A, Durrens P, Calmels C, Parissi V, Recordon P, Bon E, Desjobert C, Tarrago-Litvak L, Fournier M (2002) HIV-1 integrase interacts with yeast microtubule-associated proteins. Biochim Biophys Acta 1575:40-48 (Pubitemid 34521775)
15. Desfarges S, Salin B, Calmels C, Andreola ML, Parissi V, Fournier M (2009) HIV-1 integrase trafficking in S. cerevisiae: a useful model to dissect the microtubule network involvement of viral protein nuclear import. Yeast 26:39-54
16. Devroe E, Engelman A, Silver PA (2003) Intracellular transport of human immunodeficiency virus type 1 integrase. J Cell Sci 116:4401-4408 (Pubitemid 37369595)
17. Engelman A, Cherepanov P (2008) The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. PLoS Pathog 4:e1000046
18. Gallay P, Hope T, Chin D, Trono D (1997) HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. Proc Natl Acad Sci USA 94:9825-9830 (Pubitemid 27408149)
19. Ge H, Si Y, Roeder RG (1998) Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J 17:6723-6729 (Pubitemid 28521805)
20. Goff SP (2007) Host factors exploited by retroviruses. Nat Rev Microbiol 5:253-263 (Pubitemid 46443602)
21. Gorlich D (1998) Transport into and out of the cell nucleus. EMBO J 17:2721-2727 (Pubitemid 28227118)
22. Guo D, Hazbun TR, Xu XJ, Ng SL, Fields S, Kuo MH (2004) A tethered catalysis, two-hybrid system to identify protein-protein interactions requiring post-translational modifications. Nat Biotechnol 22:888-892 (Pubitemid 38886610)
23. Hearps AC, Jans DA (2006) HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism. Biochem J 398:475-484 (Pubitemid 44453392)
24. Hindmarsh P, Ridky T, Reeves R, Andrake M, Skalka AM, Leis J (1999) HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro. J Virol 73:2994-3003 (Pubitemid 29135688)
25. Hinnebusch AG (2006) eIF3: a versatile scaffold for translation initiation complexes. Trends Biochem Sci 31:553-562 (Pubitemid 44436942)
26. Hock R, Wilde F, Scheer U, Bustin M (1998) Dynamic relocation of chromosomal protein HMG-17 in the nucleus is dependent on transcriptional activity. EMBO J 17:6992-7001 (Pubitemid 28550293)
27. Howell B, Larsson N, Gullberg M, Cassimeris L (1999) Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin. Mol Biol Cell 10:105-118 (Pubitemid 29156930)
28. Kutay U, Bischoff FR, Kostka S, Kraft R, Gorlich D (1997) Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. Cell 90:1061-1071 (Pubitemid 27408520)
29. Li L, Yoder K, Hansen MS, Olvera J, Miller MD, Bushman FD (2000) Retroviral cDNA integration: stimulation by HMG I family proteins. J Virol 74:10965-10974 (Pubitemid 32223961)
30. Llano M, Vanegas M, Fregoso O, Saenz D, Chung S, Peretz M, Poeschla EM (2004) LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol 78:9524-9537 (Pubitemid 39096559)
31. Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, Engelborghs Y (2003) LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J Biol Chem 278:33528-33539 (Pubitemid 37055807)
32. Mitchell RS, Beitzel BF, Schroder AR, Shinn P, Chen H, Berry CC, Ecker JR, Bushman FD (2004) Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol 2:E234
33. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K et al (2004) Complete sequencing and characterization of 21, 243 full-length human cDNAs. Nat Genet 36:40-45 (Pubitemid 38056206)
34. Parissi V, Calmels C, de Soultrait VR, Caumont A, Fournier M, Chaignepain S, Litvak S (2001) Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60. J Virol 75:11344-11353 (Pubitemid 33063225)
35. Rachez C, Freedman LP (2001) Mediator complexes and transcription. Curr Opin Cell Biol 13:274-280 (Pubitemid 32429491)
36. Rain JC, Cribier A, Gerard A, Emiliani S, Benarous R (2009) Yeast two-hybrid detection of integrase-host factor interactions. Methods 47:291-297
37. Schroder AR, Shinn P, Chen H, Berry C, Ecker JR, Bushman F (2002) HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110:521-529 (Pubitemid 35232295)
38. Shun MC, Raghavendra NK, Vandegraaff N, Daigle JE, Hughes S, Kellam P, Cherepanov P, Engelman A (2007) LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes Dev 21:1767-1778 (Pubitemid 47076476)
39. Solsbacher J, Maurer P, Bischoff FR, Schlenstedt G (1998) Cse1p is involved in export of yeast importin alpha from the nucleus. Mol Cell Biol 18:6805-6815 (Pubitemid 28500568)
40. Sripathy SP, Stevens J, Schultz DC (2006) The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression. Mol Cell Biol 26:8623-8638 (Pubitemid 44748593)
41. Sterner DE, Berger SL (2000) Acetylation of histones and transcription- related factors. Microbiol Mol Biol Rev 64:435-459 (Pubitemid 30412680)
42. Studamire B, Goff SP (2008) Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors. Retrovirology 5:48
43. Suzuki Y, Craigie R (2007) The road to chromatin-nuclear entry of retroviruses. Nat Rev Microbiol 5:187-196
44. Valente ST, Gilmartin GM, Mott C, Falkard B, Goff SP (2009) Inhibition of HIV-1 replication by eIF3f. Proc Natl Acad Sci USA 106:4071-4078
45. Van Maele B, Busschots K, Vandekerckhove L, Christ F, Debyser Z (2006) Cellular co-factors of HIV-1 integration. Trends Biochem Sci 31:98-105 (Pubitemid 43221842)
46. Vandegraaff N, Engelman A (2007) Molecular mechanisms of HIV integration and therapeutic intervention. Expert Rev Mol Med 9:1-19 (Pubitemid 46358400)
47. Wang GP, Ciuffi A, Leipzig J, Berry CC, Bushman FD (2007) HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications. Genome Res 17:1186-1194 (Pubitemid 47204862)
48. West KL (2004) HMGN proteins play roles in DNA repair and gene expression in mammalian cells. Biochem Soc Trans 32:918-919 (Pubitemid 39655504)
49. Wolf D, Goff SP (2007) TRIM28 mediates primer binding sitetargeted silencing of murine leukemia virus in embryonic cells. Cell 131:46-57 (Pubitemid 47498526)
50. Wu-Baer F, Lane WS, Gaynor RB (1996) Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. J Biol Chem 271:4201-4208 (Pubitemid 26070522)
51. Zheng XM, Black D, Chambon P, Egly JM (1990) Sequencing and expression of complementary DNA for the general transcription factor BTF3. Nature 344:556-559