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Volumn 5, Issue 1, 2012, Pages 17-21

Phosphorylated T567 ezrin is associated with merlin expression in KIT-mutant gastrointestinal stromal tumors

Author keywords

Ezrin; KIT; Merlin; P ezrinThr567; P ezrinTyr146; P ezrinTyr353

Indexed keywords

EZRIN; MERLIN; STEM CELL FACTOR RECEPTOR; THREONINE;

EID: 84855212128     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.609     Document Type: Article
Times cited : (5)

References (46)
  • 2
    • 1442304609 scopus 로고    scopus 로고
    • Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
    • DOI 10.1038/nm966
    • Yu Y, Khan J, Khanna C, et al: Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. Nat Med 10: 175-181, 2004. (Pubitemid 38524888)
    • (2004) Nature Medicine , vol.10 , Issue.2 , pp. 175-181
    • Yu, Y.1    Khan, J.2    Khanna, C.3    Helman, L.4    Meltzer, P.S.5    Merlino, G.6
  • 3
    • 77953682809 scopus 로고    scopus 로고
    • Clinical value of ezrin expression in primary osteosarcoma
    • Kim C, Shin E, Hong S, et al: Clinical value of ezrin expression in primary osteosarcoma. Cancer Res Treat 41: 138-144, 2009.
    • (2009) Cancer Res Treat , vol.41 , pp. 138-144
    • Kim, C.1    Shin, E.2    Hong, S.3
  • 4
    • 65249137692 scopus 로고    scopus 로고
    • Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma
    • Xu-Dong S, Zan S, Shui-er Z, et al: Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma. Clin Invest Med 32: E180-188, 2009.
    • (2009) Clin Invest Med , vol.32
    • Xu-Dong, S.1    Zan, S.2    Shui-er, Z.3
  • 5
    • 63449108505 scopus 로고    scopus 로고
    • Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw
    • Park HR, Cabrini RL, Araujo ES, et al: Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw. Tumori 95: 81-86, 2009.
    • (2009) Tumori , vol.95 , pp. 81-86
    • Park, H.R.1    Cabrini, R.L.2    Araujo, E.S.3
  • 6
    • 30644462746 scopus 로고    scopus 로고
    • The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells
    • Elliott BE, Meens JA, SenGupta SK, et al: The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res 7: R365-R373, 2005.
    • (2005) Breast Cancer Res , vol.7
    • Elliott, B.E.1    Meens, J.A.2    SenGupta, S.K.3
  • 7
    • 38949088292 scopus 로고    scopus 로고
    • Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells
    • Li Q, Wu M, Wang H, et al: Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells. Cancer Lett 261: 55-63, 2008.
    • (2008) Cancer Lett , vol.261 , pp. 55-63
    • Li, Q.1    Wu, M.2    Wang, H.3
  • 9
    • 24344464300 scopus 로고    scopus 로고
    • Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas
    • DOI 10.1158/1078-0432.CCR-05-0548
    • Weng WH, Ahlen J, Astrom K, et al: Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas. Clin Cancer Res 11: 6198-6204, 2005. (Pubitemid 41262948)
    • (2005) Clinical Cancer Research , vol.11 , Issue.17 , pp. 6198-6204
    • Weng, W.-H.1    Ahlen, J.2    Astrom, K.3    Lui, W.-O.4    Larsson, C.5
  • 10
    • 0042624919 scopus 로고    scopus 로고
    • Ezrin immunoreactivity in relation to survival in serous ovarian carcinoma patients
    • DOI 10.1016/S0090-8258(03)00262-2
    • Moilanen J, Lassus H, Leminen A, et al: Ezrin immunoreactivity in relation to survival in serous ovarian carcinoma patients. Gynecol Oncol 90: 273-281, 2003. (Pubitemid 36952014)
    • (2003) Gynecologic Oncology , vol.90 , Issue.2 , pp. 273-281
    • Moilanen, J.1    Lassus, H.2    Leminen, A.3    Vaheri, A.4    Butzow, R.5    Carpen, O.6
  • 13
    • 42449105743 scopus 로고    scopus 로고
    • Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia
    • Monni R, Haddaoui L, Naba A, et al: Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia. Blood 111: 3163.3172, 2008.
    • (2008) Blood , vol.111
    • Monni, R.1    Haddaoui, L.2    Naba, A.3
  • 14
  • 17
    • 0025677446 scopus 로고
    • Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans
    • Kansas GS, Muirhead MJ and Dailey MO: Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans. Blood 76: 2483-2492, 1990.
    • (1990) Blood , vol.76 , pp. 2483-2492
    • Kansas, G.S.1    Muirhead, M.J.2    Dailey, M.O.3
  • 19
    • 0037572145 scopus 로고    scopus 로고
    • Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation
    • DOI 10.1091/mbc.E02-07-0410
    • Pujuguet P, Del Maestro L, Gautreau A, et al: Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation. Mol Biol Cell 14: 2181-2191, 2003. (Pubitemid 36583562)
    • (2003) Molecular Biology of the Cell , vol.14 , Issue.5 , pp. 2181-2191
    • Pujuguet, P.1    Del, M.L.2    Gautreau, A.3    Louvard, D.4    Arpin, M.5
  • 20
    • 2942516208 scopus 로고    scopus 로고
    • Phosphorylation of ezrin on threonine T567 plays a crucial role during compaction in the mouse early embryo
    • DOI 10.1016/j.ydbio.2004.03.024, PII S0012160604002350
    • Dard N, Louvet-Vallee S, Santa-Maria A, et al: Phosphorylation of ezrin on threonine T567 plays a crucial role during compaction in the mouse early embryo. Dev Biol 271: 87-97, 2004. (Pubitemid 38757777)
    • (2004) Developmental Biology , vol.271 , Issue.1 , pp. 87-97
    • Dard, N.1    Louvet-Vallee, S.2    Santa-Maria, A.3    Maro, B.4
  • 21
    • 0030728056 scopus 로고    scopus 로고
    • CD44 expression is aberrant in benign Schwann cell tumors possessing mutations in the neurofibromatosis type 2, but not type 1, gene
    • Sherman L, Jacoby LB, Lampe J, et al: CD44 expression is aberrant in benign Schwann cell tumors possessing mutations in the neurofibromatosis type 2, but not type 1, gene. Cancer Res 57: 4889-4897, 1997. (Pubitemid 27468999)
    • (1997) Cancer Research , vol.57 , Issue.21 , pp. 4889-4897
    • Sherman, L.1    Jacoby, L.B.2    Lampe, J.3    Pelton, P.4    Aguzzi, A.5    Herrlich, P.6    Ponta, H.7
  • 23
    • 34247609343 scopus 로고    scopus 로고
    • Shedding light on Merlin's wizardry
    • DOI 10.1016/j.tcb.2007.03.006, PII S0962892407000839
    • Okada T, You L and Giancotti FG: Shedding light on Merlin's wizardry. Trends Cell Biol 17: 222-229, 2007. (Pubitemid 46679247)
    • (2007) Trends in Cell Biology , vol.17 , Issue.5 , pp. 222-229
    • Okada, T.1    You, L.2    Giancotti, F.G.3
  • 26
    • 0036303804 scopus 로고    scopus 로고
    • Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    • Heinrich MC, Rubin BP, Longley BJ, et al: Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol 33: 484-495, 2002.
    • (2002) Hum Pathol , vol.33 , pp. 484-495
    • Heinrich, M.C.1    Rubin, B.P.2    Longley, B.J.3
  • 29
    • 70349673599 scopus 로고    scopus 로고
    • Ezrin overexpression in gastro-intestinal stromal tumors: An independent adverse prognosticator associated with the non-gastric location
    • Wei YC, Li CF, Yu SC, et al: Ezrin overexpression in gastro-intestinal stromal tumors: an independent adverse prognosticator associated with the non-gastric location. Mod Pathol 22: 1351-1360, 2009.
    • (2009) Mod Pathol , vol.22 , pp. 1351-1360
    • Wei, Y.C.1    Li, C.F.2    Yu, S.C.3
  • 30
    • 2442710105 scopus 로고    scopus 로고
    • Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma
    • DOI 10.1309/A7M2-XTMJ-QK0K-PQER
    • Pan CC, Chen PC and Chiang H: Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol 121: 878-883, 2004. (Pubitemid 38669283)
    • (2004) American Journal of Clinical Pathology , vol.121 , Issue.6 , pp. 878-883
    • Pan, C.-C.1    Chen, P.C.-H.2    Chiang, H.3
  • 31
    • 70350340074 scopus 로고    scopus 로고
    • Chromophobe renal cell cancer--review of the literature and potential methods of treating metastatic disease
    • Stec R, Grala B, Maczewski M, et al: Chromophobe renal cell cancer--review of the literature and potential methods of treating metastatic disease. J Exp Clin Cancer Res 28: 134, 2009.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 134
    • Stec, R.1    Grala, B.2    Maczewski, M.3
  • 32
    • 0037434795 scopus 로고    scopus 로고
    • Overexpression of KIT in chromophobe renal cell carcinoma
    • DOI 10.1038/sj.onc.1206153
    • Yamazaki K, Sakamoto M, Ohta T, et al: Overexpression of KIT in chromophobe renal cell carcinoma. Oncogene 22: 847-852, 2003. (Pubitemid 36255820)
    • (2003) Oncogene , vol.22 , Issue.6 , pp. 847-852
    • Yamazaki, K.1    Sakamoto, M.2    Ohta, T.3    Kanai, Y.4    Ohki, M.5    Hirohashi, S.6
  • 33
    • 2642565305 scopus 로고    scopus 로고
    • A distinct expression pattern and point mutation of c-kit in papillary renal cell carcinomas
    • DOI 10.1038/modpathol.3800108
    • Lin ZH, Han EM, Lee ES, et al: A distinct expression pattern and point mutation of c-kit in papillary renal cell carcinomas. Mod Pathol 17: 611-616, 2004. (Pubitemid 38715481)
    • (2004) Modern Pathology , vol.17 , Issue.6 , pp. 611-616
    • Lin, Z.-H.1    Han, E.M.2    Lee, E.S.3    Kim, C.W.4    Kim, H.K.5    Kim, I.6    Kim, Y.-S.7
  • 35
    • 33749461709 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor
    • DOI 10.1158/0008-5472.CAN-06-0165
    • Bauer S, Yu LK, Demetri GD, et al: Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res 66: 9153-9161, 2006. (Pubitemid 44521135)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9153-9161
    • Bauer, S.1    Yu, L.K.2    Demetri, G.D.3    Fletcher, J.A.4
  • 36
    • 0022589111 scopus 로고
    • The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein
    • Gould KL, Cooper JA, Bretscher A, et al: The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein. J Cell Biol 102: 660-669, 1986. (Pubitemid 16140828)
    • (1986) Journal of Cell Biology , vol.102 , Issue.2 , pp. 660-669
    • Gould, K.L.1    Cooper, J.A.2    Bretscher, A.3    Hunter, T.4
  • 37
    • 33644527303 scopus 로고    scopus 로고
    • Merlin facilitates ubiquitination and degradation of transactivation- responsive RNA-binding protein
    • Lee JY, Moon HJ, Lee WK, et al: Merlin facilitates ubiquitination and degradation of transactivation-responsive RNA-binding protein. Oncogene 25: 1143-1152, 2006.
    • (2006) Oncogene , vol.25 , pp. 1143-1152
    • Lee, J.Y.1    Moon, H.J.2    Lee, W.K.3
  • 38
    • 68349122458 scopus 로고    scopus 로고
    • Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma
    • Yeh CN, Pang ST, Chen TW, et al: Expression of ezrin is associated with invasion and dedifferentiation of hepatitis B related hepatocellular carcinoma. BMC Cancer 9: 233, 2009.
    • (2009) BMC Cancer , vol.9 , pp. 233
    • Yeh, C.N.1    Pang, S.T.2    Chen, T.W.3
  • 39
    • 27144490037 scopus 로고    scopus 로고
    • Ezrin expression in prostate cancer and benign prostatic tissue
    • Valdman A, Fang X, Pang ST, et al: Ezrin expression in prostate cancer and benign prostatic tissue. Eur Urol 48: 852-857, 2005.
    • (2005) Eur Urol , vol.48 , pp. 852-857
    • Valdman, A.1    Fang, X.2    Pang, S.T.3
  • 40
    • 58449089776 scopus 로고    scopus 로고
    • Stem cell factor induces ERM protein phosphorylation through PI3K activation to mediate melanocyte proliferation and migration
    • Jeon S, Kim NH, Kim JY, et al: Stem cell factor induces ERM protein phosphorylation through PI3K activation to mediate melanocyte proliferation and migration. Pigment Cell Melanoma Res 22: 77-85, 2009.
    • (2009) Pigment Cell Melanoma Res , vol.22 , pp. 77-85
    • Jeon, S.1    Kim, N.H.2    Kim, J.Y.3
  • 41
    • 77954243903 scopus 로고    scopus 로고
    • Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell
    • Di Cristofano C, Leopizzi M, Miraglia A, et al: Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell. Mod Pathol 23: 1012-1020, 2010.
    • (2010) Mod Pathol , vol.23 , pp. 1012-1020
    • Di Cristofano, C.1    Leopizzi, M.2    Miraglia, A.3
  • 42
    • 77149179521 scopus 로고    scopus 로고
    • Expression of Ezrin and phosphorylated Ezrin (pEzrin) in pancreatic ductal adenocarcinoma
    • Cui Y, Li T, Zhang, et al: Expression of Ezrin and phosphorylated Ezrin (pEzrin) in pancreatic ductal adenocarcinoma. Cancer Invest 28: 242-247, 2010.
    • (2010) Cancer Invest , vol.28 , pp. 242-247
    • Cui, Y.1    Li, T.2    Zhang3
  • 43
    • 0032482323 scopus 로고    scopus 로고
    • Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44
    • Legg JW and Isacke CM: Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44. Curr Biol 8: 705-708, 1998. (Pubitemid 28286278)
    • (1998) Current Biology , vol.8 , Issue.12 , pp. 705-708
    • Legg, J.W.1    Isacke, C.M.2
  • 44
    • 33846702026 scopus 로고    scopus 로고
    • Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
    • DOI 10.1158/0008-5472.CAN-06-1608
    • Morrison H, Sperka T, Manent J, et al: Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. Cancer Res 67: 520-527, 2007. (Pubitemid 46192188)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 520-527
    • Morrison, H.1    Sperka, T.2    Manent, J.3    Giovannini, M.4    Ponta, H.5    Herrlich, P.6
  • 45
    • 63049127084 scopus 로고    scopus 로고
    • Functional inactivation of NF2/merlin in human mesothelioma
    • Thurneysen C, Opitz I, Kurtz S, et al: Functional inactivation of NF2/merlin in human mesothelioma. Lung Cancer 64: 140-147, 2009.
    • (2009) Lung Cancer , vol.64 , pp. 140-147
    • Thurneysen, C.1    Opitz, I.2    Kurtz, S.3
  • 46
    • 3042626692 scopus 로고    scopus 로고
    • Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation
    • Fraenzer JT, Pan H, Minimo L Jr, et al: Overexpression of the NF2 gene inhibits schwannoma cell proliferation through promoting PDGFR degradation. Int J Oncol 23: 1493-1500, 2003.
    • (2003) Int J Oncol , vol.23 , pp. 1493-1500
    • Fraenzer, J.T.1    Pan, H.2    Minimo Jr., L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.