Synthesis of 5-aryl-1,4-benzodiazepine derivatives attached in resorcinaren-PAMAM dendrimers and their anti-cancer activity

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 415-421

  Cortez Maya, Sandra ^a   Hernández Ortega, Simón ^a   Ramírez Apan, Teresa ^a   Lijanova, Irina V ^b   Martínez García, Marcos ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Anticancer activity; Benzodiazepines; Dendrimers; PAMAM; Resorcinarenes

Indexed keywords

ANTINEOPLASTIC AGENT; ARYL 1,4 BENZODIAZEPINE DERIVATIVE; DENDRIMER; METHYL 2 (7 CHLORO 5 (2 CHLOROPHENYL) 2 OXO 2,3 DIHYDRO 1 H BENZO[E][1,4]DIAZEPIN 1 YL) ACETATE; METHYL 2 (7 CHLORO 5 (2 FLUOROPHENYL) 2 OXO 2,3 DIHYDRO 1 H BENZO[E][1,4]DIAZEPIN 1 YL) ACETATE; METHYL 2 (7 CHLORO OXO 5 PHENYL 2,3 DIHYDRO 1 H BENZO[E][1,4]DIAZEPAM 1 YL) ACETATE; METHYL 2 (7 NITRO 2 OXO 5 PHENYL 2,3 DIHYDRO 1 H BENZO[E][1,4]DIAZEPIN 1 YL) ACETATE; POLYAMIDOAMINE; RESORCINAREN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY TEST; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; CALIXARENES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DENDRIMERS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR CONFORMATION; PHENYLALANINE;

EID: 84855194558     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.070     Document Type: Article

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