Investigation of substituted 6-aminohexanoates as skin penetration enhancers

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 86-95

  Brychtova, Katerina ^a   Dvorakova, Lenka ^a   Opatrilova, Radka ^a   Raich, Ivan ^b   Kacerova, Sandra ^b   Placek, Lukas ^c   Kalinowski, Danuta S ^d   Richardson, Des R ^d   Jampilek, Josef ^a  

^a UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^b INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

^c Patol Sro   (Czech Republic)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Lactam derivatives; 3D structures; 6 Aminohexanoic acid derivatives; Ab initio calculations; Anti proliferative activity; Lipophilicity; Molecular dynamic simulations; Transdermal penetration enhancers

Indexed keywords

6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID; ALKYL 6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID; DECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOAZEPAN 1 YL)HEXANOIC ACID; DECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID; DODECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOAZEPAN 1 YL)HEXANOIC ACID; DODECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID; ESTER DERIVATIVE; ETHYL 2 BROMO 6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID; ETHYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOAZEPAN 1 YL)HEXANOIC ACID; HEPTYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOAZEPAN 1 YL)HEXANOIC ACID; HEPTYL 6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID; HEXYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOAZEPAN 1 YL)HEXANOIC ACID; HEXYL 6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID; LAUROCAPRAM; NONYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOAZEPAN 1 YL)HEXANOIC ACID; NONYL 6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID; OCTYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOAZEPAN 1 YL)HEXANOIC ACID; OCTYL 6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID; OLEIC ACID; PENETRATION ENHANCING AGENT; SUBSTITUTED 6 AMINOHEXANOIC ACID; UNCLASSIFIED DRUG; UNDECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOAZEPAN 1 YL)HEXANOIC ACID; UNDECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL)HEXANOIC ACID;

AB INITIO CALCULATION; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GEOMETRY; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; IN VITRO STUDY; LIPOPHILICITY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SKIN PENETRATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THREE DIMENSIONAL IMAGING;

6-AMINOCAPROIC ACID; ADMINISTRATION, TOPICAL; ANIMALS; ANTINEOPLASTIC AGENTS; CAPROATES; CELL LINE, TUMOR; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR DYNAMICS SIMULATION; PYRROLIDINES; SKIN; SKIN ABSORPTION; STEREOISOMERISM; SWINE;

EID: 84855189679     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.033     Document Type: Article

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