Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 22, 2007, Pages 6943-6955

  Baert, Bram ^a   Deconinck, Eric ^b   Van Gele, Mireille ^c   Slodicka, Marian ^d   Stoppie, Paul ^e   Bodé, Samuel ^a   Slegers, Guido ^a   Vander Heyden, Yvan ^b   Lambert, Jo ^c   Beetens, Johan ^e   De Spiegeleer, Bart ^a  

^a Faculty of Pharmaceutical Sciences   (Belgium)

^b PHARMACEUTICAL INSTITUTE   (Belgium)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

^e Barrier Therapeutics NV   (Belgium)

Author keywords

CART; Drugs; QSPR; Transdermal permeability

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE; AMINOPHENAZONE; AMOBARBITAL; AMPHETAMINE; ASPARTIC ACID; ATENOLOL; ATROPINE; BACLOFEN; BARBITAL; BENZOIC ACID; BETAMETHASONE; BETAMETHASONE VALERATE; BUTETHAL; CHLOROXYLENOL; CHLORPHENIRAMINE; CLONIDINE; CODEINE; CORTICOSTERONE; CORTISONE; CORTODOXONE; COUMARIN; CYCLOBARBITAL; DEXAMETHASONE; DEXTROMETHORPHAN; DIAZEPAM; DICLOFENAC; PARACETAMOL; PHENAZONE; UNINDEXED DRUG;

ARTICLE; DRUG CLASSIFICATION; DRUG PENETRATION; DRUG STRUCTURE; MULTIPLE LINEAR REGRESSION ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS; SKIN PENETRATION; STANDARD; STATISTICAL ANALYSIS; STATISTICAL MODEL; VALIDATION PROCESS;

ANTI-INFLAMMATORY AGENTS; CELL MEMBRANE PERMEABILITY; CLUSTER ANALYSIS; DRUG EVALUATION, PRECLINICAL; HUMANS; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS; SKIN; SKIN ABSORPTION;

EID: 34548863911     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.050     Document Type: Article

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