Investigating the activity of 2-substituted alkyl-6-(2,5-dioxopyrrolidin-1- yl)hexanoates as skin penetration enhancers

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 24, 2010, Pages 8556-8565

  Brychtova, Katerina ^a   Opatrilova, Radka ^a   Raich, Ivan ^b   Kalinowski, Danuta S ^c   Dvorakova, Lenka ^a   Placek, Lukas ^d   Csollei, Jozef ^a   Richardson, Des R ^c   Jampilek, Josef ^a,d  

^a UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^b INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

^c UNIVERSITY OF SYDNEY   (Australia)

^d Zentiva Prague   (Czech Republic)

Author keywords

Lactam derivatives; 3D structures; 6 Aminohexanoic acid derivatives; Ab initio calculations; Anti proliferative activity; Lipophilicity; Molecular dynamic simulations; Transdermal penetration enhancers

Indexed keywords

DECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOPIPERIDIN 1 YL)HEXANOATE; DECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (MORPHOLIN 4 YL)HEXANOATE; DODECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOPIPERIDIN 1 YL)HEXANOATE; DODECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (MORPHOLIN 4 YL)HEXANOATE; ESTER; HEPTYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOPIPERIDIN 1 YL)HEXANOATE; HEPTYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (MORPHOLIN 4 YL)HEXANOATE; HEXANOIC ACID; HEXYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOPIPERIDIN 1 YL)HEXANOATE; HEXYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (MORPHOLIN 4 YL)HEXANOATE; NONYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (MORPHOLIN 4 YL)HEXANOATE; OCTYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOPIPERIDIN 1 YL)HEXANOATE; OCTYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (MORPHOLIN 4 YL)HEXANOATE; OLEIC ACID; UNCLASSIFIED DRUG; UNDECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (2 OXOPIPERIDIN 1 YL)HEXANOATE; UNDECYL 6 (2,5 DIOXOPYRROLIDIN 1 YL) 2 (MORPHOLIN 4 YL)HEXANOATE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYDROPHOBICITY; INFRARED RADIATION; LIPOPHILICITY; MASS SPECTROMETRY; MOLECULAR DYNAMICS; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIMULATION; SKIN PENETRATION;

ADMINISTRATION, CUTANEOUS; CAPROATES; DRUG CARRIERS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; SKIN ABSORPTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649451139     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.10.025     Document Type: Article

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