Serotonin-1A receptors in major depression quantified using PET: Controversies, confounds, and recommendations

NeuroImage

Volumn 59, Issue 4, 2012, Pages 3243-3251

  Shrestha, Saurav ^a,b   Hirvonen, Jussi ^a   Hines, Christina S ^a   Henter, Ioline D ^a   Svenningsson, Per ^b   Pike, Victor W ^a   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Major depressive disorder (MDD); Neuroimaging; Permeability glycoprotein (P gp); Positron emission tomography (PET); Radioligand; Serotonin 1A (5 HT 1A) receptors

Indexed keywords

GLYCOPROTEIN P; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RADIOPHARMACEUTICAL AGENT; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG; WAY 100635 C 11;

ARTERIAL BLOOD; BINDING AFFINITY; BLOOD BRAIN BARRIER; BLOOD SAMPLING; CELL MIGRATION; CEREBELLUM; HUMAN; MAJOR DEPRESSION; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOASSAY; RECEPTOR BINDING; RECEPTOR DENSITY; REVIEW; SEROTONINERGIC SYSTEM; SEROTONINERGIC TRANSMISSION;

DEPRESSIVE DISORDER, MAJOR; HUMANS; POSITRON-EMISSION TOMOGRAPHY; RECEPTOR, SEROTONIN, 5-HT1A;

EID: 84855184017     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2011.11.029     Document Type: Review

References (51)

1. Albert P.R., Francois B.L. Modifying 5-HT1A receptor gene expression as a new target for antidepressant therapy. Front Neurosci 2010, 4:35.
2. Aznavour N., Rbah L., Leger L., Buda C., Sastre J.P., Imhof A., Charnay Y., Zimmer L. A comparison of in vivo and in vitro neuroimaging of 5-HT 1A receptor binding sites in the cat brain. J. Chem. Neuroanat. 2006, 31:226-232.
3. Bauer B., Hartz A.M., Pekcec A., Toellner K., Miller D.S., Potschka H. Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol. Pharmacol. 2008, 73:1444-1453.
4. Blier P., de Montigny C. Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists. J. Cardiovasc. Pharmacol. 1990, 15(Suppl 7):S42-S48.
5. Blier P., Pineyro G., el Mansari M., Bergeron R., de Montigny C. Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Ann. N. Y. Acad. Sci. 1998, 861:204-216.
6. Carrel D., Masson J., Al Awabdh S., Capra C.B., Lenkei Z., Hamon M., Emerit M.B., Darmon M. Targeting of the 5-HT1A serotonin receptor to neuronal dendrites is mediated by Yif1B. J. Neurosci. 2008, 28:8063-8073.
7. Carson R.E., Lang L.X., Watabe H., Der M.G., Adams H.R., Jagoda E., Herscovitch P., Eckelman W.C. Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs. Nucl. Med. Biol. 2000, 27:493-497.
8. Carson R.E., Wu Y.J., Lang L.X., Ma Y., Der M.G., Herscovitch P., Eckelman W.C. Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs. J. Cerebr. Blood Flow Metab. 2003, 23:249-260.
9. David D.J., Samuels B.A., Rainer Q., Wang J.W., Marsteller D., Mendez I., Drew M., Craig D.A., Guiard B.P., Guilloux J.P., Artymyshyn R.P., Gardier A.M., Gerald C., Antonijevic I.A., Leonardo E.D., Hen R. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 2009, 62:479-493.
10. Drevets W.C., Frank E., Price J.C., Kupfer D.J., Holt D., Greer P.J., Huang Y., Gautier C., Mathis C. PET imaging of serotonin 1A receptor binding in depression. Biol. Psychiatry 1999, 46:1375-1387.
11. Drevets W.C., Thase M.E., Moses-Kolko E.L., Price J., Frank E., Kupfer D.J., Mathis C. Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nucl. Med. Biol. 2007, 34:865-877.
12. Elsinga P.H., Hendrikse N.H., Bart J., van Waarde A., Vaalburg W. Positron emission tomography studies on binding of central nervous system drugs and P-glycoprotein function in the rodent brain. Mol. Imaging Biol. 2005, 7:37-44.
13. 11C]WAY-100635 binding to central 5-HT1A receptors in man. J. Nucl. Med. 1998, 39:1965-1971.
14. Fichter K.M., Flajolet M., Greengard P., Vu T.Q. Kinetics of G-protein-coupled receptor endosomal trafficking pathways revealed by single quantum dots. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:18658-18663.
15. Gillet J.P., Gottesman M.M. Mechanisms of multidrug resistance in cancer. Methods Mol. Biol. 2010, 596:47-76.
16. Gross C., Zhuang X., Stark K., Ramboz S., Oosting R., Kirby L., Santarelli L., Beck S., Hen R. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 2002, 416:396-400.
17. Guillin O., Abi-Dargham A., Laruelle M. Neurobiology of dopamine in schizophrenia. Int. Rev. Neurobiol. 2007, 78:1-39.
18. 11C]WAY-100635 for PET. Neuroimage 1998, 8:426-440.
19. Hirvonen J., Kajander J., Allonen T., Oikonen V., Nagren K., Hietala J. Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-(11)C]WAY-100635-considerations on the validity of cerebellum as a reference region. J. Cereb. Blood Flow Metab. 2007, 27:185-195.
20. 11C]WAY-100635. Int. J. Neuropsychopharmacol. 2008, 11:465-476.
21. Kannan P., John C., Zoghbi S.S., Halldin C., Gottesman M.M., Innis R.B., Hall M.D. Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications. Clin. Pharmacol. Therapeutics 2009, 86:368-377.
22. Kusserow H., Davies B., Hortnagl H., Voigt I., Stroh T., Bert B., Deng D.R., Fink H., Veh R.W., Theuring F. Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin 1A receptors. Brain Res. Mol. Brain Res. 2004, 129:104-116.
23. 18F]MPPF uptake in rat brain and peripheral tissues: microPET and ex vivo studies. Eur. J. Nucl. Med. Mol. Imaging 2008, 35:2256-2266.
24. Leden I. Digoxin-hydroxycloroquine interaction?. Acta Med. Scand. 1982, 211:411-412.
25. Lenox R.H., Frazer A. Mechanism of action of antidepressants and mood-stabilizers. Neuropsychopharmacology: The Fifth Generation of Progress 2002, 1139-1163. Lippincott Williams & Wilkins, Baltimore, MD. K.L. Davis, D. Charney, J.T. Coyle, C. Nemeroff (Eds.).
26. 11C](R)-(-)-RWAY. Synapse 2007, 61:96-105.
27. Luttrell L.M., Lefkowitz R.J. The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell Sci. 2002, 115:455-465.
28. 11C carboxylation of an immobilized Grignard reagent. J. Label. Compd. Radiopharm. 1996, 38:941-953.
29. 11C](-)-RWAY in monkey - a new simply labeled PET radioligand for imaging brain 5-HT1A receptors. Eur. J. Nucl. Med. Mol. Imaging 2007, 34:1670-1682.
30. Meltzer C.C., Price J.C., Mathis C.A., Butters M.A., Ziolko S.K., Moses-Kolko E., Mazumdar S., Mulsant B.H., Houck P.R., Lopresti B.J., Weissfeld L.A., Reynolds C.F. Serotonin 1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology 2004, 29:2258-2265.
31. Mickey B.J., Ducci F., Hodgkinson C.A., Langenecker S.A., Goldman D., Zubieta J.K. Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo. J Neuroscience 2008, 28:11354-11359.
32. 11C]WAY-100635 - explanation of high signal in PET and an aid to biomathematical modelling. Nucl. Med. Biol. 1998, 25:215-223.
33. 11C]WAY-100635, in monkey and human plasma by HPLC - comparison of the behaviour of an identified radioactive metabolite with parent radioligand in monkey using PET. Nucl. Med. Biol. 1996, 23:627-634.
34. Parsey R.V., Arango V., Olvet D.M., Oquendo M.A., Van Heertum R.L., John Mann J. Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography. J. Cereb. Blood Flow Metab. 2005, 25:785-793.
35. Parsey R.V., Ogden R.T., Miller J.M., Tin A., Hesselgrave N., Goldstein E., Mikhno A., Milak M., Zanderigo F., Sullivan G.M., Oquendo M.A., Mann J.J. Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerations. Biol. Psychiatry 2010, 68:170-178.
36. Parsey R.V., Oquendo M.A., Ogden R.T., Olvet D.M., Simpson N., Huang Y.Y., Van Heertum R.L., Arango V., Mann J.J. Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biol. Psychiatry 2006, 59:106-113.
37. 18F]MPPF in rats. Eur. J. Pharmacol. 2000, 407:273-280.
38. Pike V.W. PET radiotracers: crossing the blood-brain barrier and surviving metabolism. TiPs 2009, 30:440-443.
39. 11C]WAY-100635. Eur. J. Pharmacol. 1995, 283:R1-R3.
40. 11C]WAY-100635. Eur. J. Pharmacol. 1996, 301:R5-R7.
41. Rasmussen S.G., Choi H.J., Fung J.J., Pardon E., Casarosa P., Chae P.S., Devree B.T., Rosenbaum D.M., Thian F.S., Kobilka T.S., Schnapp A., Konetzki I., Sunahara R.K., Gellman S.H., Pautsch A., Steyaert J., Weis W.I., Kobilka B.K. Structure of a nanobody-stabilized active state of the beta(2) adrenoceptor. Nature 2011, 469:175-180.
42. Richardson-Jones J.W., Craige C.P., Guiard B.P., Stephen A., Metzger K.L., Kung H.F., Gardier A.M., Dranovsky A., David D.J., Beck S.G., Hen R., Leonardo E.D. 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron 2010, 65:40-52.
43. 18F]FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human brain. J. Nucl. Med. 2007, 48:1154-1161.
44. 11C]WAY-100635: effects of depression and antidepressant treatment. Arch. Gen. Psychiatry 2000, 57:174-180.
45. Schatzberg A.F., Garlow S.J., Nemeroff C.B. Molecular and cellular mechanisms in depression. Neuropsychopharmacology: The Fifth Generation of Progress 2002, 1039-1050. Lippincott Williams & Wilkins, Baltimore, MD. K.L. Davis, D. Charney, J.T. Coyle, C. Nemeroff (Eds.).
46. Soldin S.J. Free drug measurements. When and why? An overview. Arch. Pathol. Lab. Med. 1999, 123:822-823.
47. Stockmeier C.A., Howley E., Shi X., Sobanska A., Clarke G., Friedman L., Rajkowska G. Antagonist but not agonist labeling of serotonin-1A receptors is decreased in major depressive disorder. J. Psychiatr. Res. 2009, 43:887-894.
48. Theodore W.H., Hasler G., Giovacchini G., Kelley K., Reeves-Tyer P., Herscovitch P., Drevets W. Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsy. Epilepsia 2007, 48:1526-1530.
49. 11C](R)-(-)-RWAY. Synapse 2006, 60:510-520.
50. 11C](R)-(-)-RWAY: radiometabolite(s) likely confound brain measurements. Synapse 2007, 61:469-477.
51. Zimmer L., Riad M., Rbah L., Belkacem-Kahlouli A., Le Bars D., Renaud B., Descarries L. Toward brain imaging of serotonin 5-HT1A autoreceptor internalization. Neuroimage 2004, 22(3):1421-1426.