The confluence of stereotactic ablative radiotherapy and tumor immunology

Clinical and Developmental Immunology

Volumn 2011, Issue , 2011, Pages

  Finkelstein, Steven Eric ^a   Timmerman, Robert ^b   McBride, William H ^c   Schaue, Drthe ^c   Hoffe, Sarah E ^d   Mantz, Constantine A ^a   Wilson, George D ^e  

^a 21ST CENTURY ONCOLOGY   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Department of Radiation Oncology Moffitt International ^*  (United States)

^e WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CYTOKINE; DEATH RECEPTOR; HEAT SHOCK PROTEIN; B7 ANTIGEN;

BRAIN TUMOR; CANCER CELL; CANCER RADIOTHERAPY; DENDRITIC CELL; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION DOSE FRACTIONATION; REVIEW; STEREOTACTIC BODY RADIATION THERAPY; STROMA; TUMOR IMMUNOLOGY; ANIMAL; APOPTOSIS; HUMAN; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LIVER TUMOR; LUNG TUMOR; MAJOR HISTOCOMPATIBILITY COMPLEX; METHODOLOGY; MOUSE; MOUSE MUTANT; NEOPLASM; RADIATION EXPOSURE; RADIOSURGERY; TUMOR ESCAPE;

ANIMALS; ANTIGENS, CD80; APOPTOSIS; BRAIN NEOPLASMS; CELL ADHESION MOLECULES; CYTOKINES; HEAT-SHOCK PROTEINS; HUMANS; IMMUNE SYSTEM; IMMUNE TOLERANCE; LIVER NEOPLASMS; LUNG NEOPLASMS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, KNOCKOUT; NEOPLASMS; RADIOSURGERY; RECEPTORS, DEATH DOMAIN; TUMOR ESCAPE;

EID: 84855175162     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2011/439752     Document Type: Review

References (48)

1. Brenner D. J., The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction Seminars in Radiation Oncology 2008 18 4 234 239
2. Kirkpatrick J. P., Meyer J. J., Marks L. B., The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery Seminars in Radiation Oncology 2008 18 4 240 243
3. Leith J. T., Cook S., Chougule P., Calabresi P., Wahlberg L., Lindquist C., Epstein M., Intrinsic and extrinsic characteristics of human tumors relevant to radiosurgery: comparative cellular radiosensitivity and hypoxic percentages Acta Neurochirurgica, Supplement 1994 62 18 27
4. Guerrero M., Li X. A., Extending the linear-quadratic model for large fraction doses pertinent to stereotactic radiotherapy Physics in Medicine and Biology 2004 49 20 4825 4835 (Pubitemid 39433509)
5. Park C., Papiez L., Zhang S., Story M., Timmerman R. D., Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy International Journal of Radiation Oncology Biology Physics 2008 70 3 847 852 (Pubitemid 351199730)
6. Garcia-Barros M., Paris F., Cordon-Cardo C., Lyden D., Rafii S., Haimovitz-Friedman A., Fuks Z., Kolesnick R., Tumor response to radiotherapy regulated by endothelial cell apoptosis Science 2003 300 5622 1155 1159 (Pubitemid 36583102)
7. Truman J. P., Garca-Barros M., Kaag M., Hambardzumyan D., Stancevic B., Chan M., Fuks Z., Kolesnick R., Haimovitz-Friedman A., Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery PLoS One 2010 5 8
8. Utermhlen O., Karow U., Lhler J., Krnke M., Severe impairment in early host defense against Listeria monocytogenes in mice deficient in acid sphingomyelinase Journal of Immunology 2003 170 5 2621 2628 (Pubitemid 36245654)
9. Chen F. H., Chiang C. S., Wang C. C., Tsai C. S., Jung S. M., Lee C. C., McBride W. H., Hong J. H., Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors Clinical Cancer Research 2009 15 5 1721 1729
10. Szeifert G. T., Kondziolka D., Atteberry D. S., Salmon I., Rorive S., Levivier M., Lunsford L. D., Radiosurgical pathology of brain tumors: metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas Progress in neurological surgery 2007 20 91 105
11. Wasserman J., Blomgren H., Rotstein S., Petrini B., Hammarstrom S., Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors Bulletin of the New York Academy of Medicine 1989 65 1 36 44 (Pubitemid 19065026)
12. North R. J., Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells Journal of Experimental Medicine 1986 164 5 1652 1666 (Pubitemid 17184195)
13. Demaria S., Kawashima N., Yang A. M., Devitt M. L., Babb J. S., Allison J. P., Formenti S. C., Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer Clinical Cancer Research 2005 11 2 I 728 734 (Pubitemid 40116901)
14. Ohuchida K., Mizumoto K., Murakami M., Qian L. W., Sato N., Nagai E., Matsumoto K., Nakamura T., Tanaka M., Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions Cancer Research 2004 64 9 3215 3222 (Pubitemid 38581425)
15. Merrick A., Errington F., Milward K., O'Donnell D., Harrington K., Bateman A., Pandha H., Vile R., Morrison E., Selby P., Melcher A., Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of nave T-cell priming British Journal of Cancer 2005 92 8 1450 1458 (Pubitemid 40705012)
16. Reits E. A., Hodge J. W., Herberts C. A., Groothuis T. A., Chakraborty M., Wansley E. K., Camphausen K., Luiten R. M., De Ru A. H., Neijssen J., Griekspoor A., Mesman E., Verreck F. A., Spits H., Schlom J., Van Veelen P., Neefjes J. J., Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy Journal of Experimental Medicine 2006 203 5 1259 1271 (Pubitemid 43736595)
17. Galon J., Costes A., Sanchez-Cabo F., Kirilovsky A., Mlecnik B., Lagorce-Pags C., Tosolini M., Camus M., Berger A., Wind P., Zinzindohoué F., Bruneval P., Cugnenc P. H., Trajanoski Z., Fridman W. H., Pags F., Type, density, and location of immune cells within human colorectal tumors predict clinical outcome Science 2006 313 5795 1960 1964 (Pubitemid 44498003)
18. Apetoh L., Ghiringhelli F., Tesniere A., Obeid M., Ortiz C., Criollo A., Mignot G., Maiuri M. C., Ullrich E., Saulnier P., Yang H., Amigorena S., Ryffel B., Barrat F. J., Saftig P., Levi F., Lidereau R., Nogues C., Mira J. P., Chompret A., Joulin V., Clavel-Chapelon F., Bourhis J., André F., Delaloge S., Tursz T., Kroemer G., Zitvogel L., Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy Nature Medicine 2007 13 9 1050 1059 (Pubitemid 47517504)
19. Chakraborty M., Abrams S. I., Coleman C. N., Camphausen K., Schlom J., Hodge J. W., External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing Cancer Research 2004 64 12 4328 4337 (Pubitemid 38802440)
20. Finkelstein S. E., Heimann D. M., Klebanoff C. A., Antony P. A., Gattinoni L., Hinrichs C. S., Hwang L. N., Palmer D. C., Spiess P. J., Surman D. R., Wrzesiniski C., Yu Z., Rosenberg S. A., Restifo N. P., Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer Journal of Leukocyte Biology 2004 76 2 333 337 (Pubitemid 39006946)
21. Liao Y. P., Wang C. C., Schaue D., Iwamoto K. S., McBride W. H., Local irradiation of murine melanoma affects the development of tumour-specific immunity Immunology 2009 128 1 e797 e804
22. Lugade A. A., Moran J. P., Gerber S. A., Rose R. C., Frelinger J. G., Lord E. M., Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumor Journal of Immunology 2005 174 12 7516 7523 (Pubitemid 40806254)
23. Stone H. B., Peters L. J., Milas L., Effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma Journal of the National Cancer Institute 1979 63 5 1229 1235 (Pubitemid 10159225)
24. Lee Y., Auh S. L., Wang Y., Burnette B., Wang Y., Meng Y., Beckett M., Sharma R., Chin R., Tu T., Weichselbaum R. R., Fu Y. X., Therapeutic effects of ablative radiation on local tumor require CD8 + T cells: changing strategies for cancer treatment Blood 2009 114 3 589 595
25. Dewan M. Z., Galloway A. E., Kawashima N., Dewyngaert J. K., Babb J. S., Formenti S. C., Demaria S., Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody Clinical Cancer Research 2009 15 17 5379 5388
26. Schaue D., Comin-Anduix B., Ribas A., Zhang L., Goodglick L., Sayre J. W., Debucquoy A., Haustermans K., McBride W. H., T-cell responses to survivin in cancer patients undergoing radiation therapy Clinical Cancer Research 2008 14 15 4883
27. Restifo N. P., Antony P. A., Finkelstein S. E., Leitner W. W., Surman D. R., Theoret M. R., Touloukian C. E., Assumptions of the tumor escape hypothesis Seminars in Cancer Biology 2002 12 1 81 86
28. Friedman E. J., Immune modulation by ionizing radiation and its implications for cancer immunotherapy Current Pharmaceutical Design 2002 8 19 1765 1780 (Pubitemid 34846202)
29. Overwijk W. W., Theoret M. R., Finkelstein S. E., Surman D. R., De Jong L. A., Vyth-Dreese F. A., Dellemijn T. A., Antony P. A., Spiess P. J., Palmer D. C., Heimann D. M., Klebanoff C. A., Yu Z., Hwang L. N., Feigenbaum L., Kruisbeek A. M., Rosenberg S. A., Restifo N. P., Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8 + T cells Journal of Experimental Medicine 2003 198 4 569 580 (Pubitemid 37040391)
30. Gattinoni L., Finkelstein S. E., Klebanoff C. A., Antony P. A., Palmer D. C., Spiess P. J., Hwang L. N., Yu Z., Wrzesinski C., Heimann D. M., Surh C. D., Rosenberg S. A., Restifo N. P., Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8 + T cells Journal of Experimental Medicine 2005 202 7 907 912 (Pubitemid 41396891)
31. Chiang C. S., McBride W. H., Radiation enhances tumor necrosis factor production by murine brain cells Brain Research 1991 566 1-2 265 269
32. Quarmby S., Kumar P., Kumar S., Radiation-induced normal tissue injury: role of adhesion molecules in leukocyte-endothelial cell interactions International Journal of Cancer 1999 82 3 385 395 (Pubitemid 29302980)
33. Ganss R., Ryschich E., Klar E., Arnold B., Hmmerling G. J., Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication Cancer Research 2002 62 5 1462 1470 (Pubitemid 34407808)
34. Nikitina E., Gabrilovich D. I., Combination of -irradiation and dendritic cell administration induces a potent antitumor response in tumor-bearing mice: approach to treatment of advanced stage cancer International Journal of Cancer 2001 94 6 825 833 (Pubitemid 33032831)
35. Ahn G. O., Brown J. M., Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: experimental models and clinical perspectives Cell Cycle 2009 8 7 970 976
36. Kachikwu E. L., Iwamoto K. S., Liao Y. P., DeMarco J. J., Agazaryan N., Economou J. S., McBride W. H., Schaue D., Radiation enhances regulatory T cell representation. International Journal of Radiation Oncology, Biology, Physics. In press
37. McBride W. H., Chiang C. S., Olson J. L., Wang C. C., Hong J. H., Pajonk F., Dougherty G. J., Iwamoto K. S., Pervan M., Liao Y. P., A sense of danger from radiation Radiation Research 2004 162 1 1 19 (Pubitemid 39044714)
38. Yee C., Riddell S. R., Greenberg P. D., In vivo tracking of tumor-specific T cells Current Opinion in Immunology 2001 13 2 141 146 (Pubitemid 32176031)
39. Dunn G. P., Bruce A. T., Ikeda H., Old L. J., Schreiber R. D., Cancer immunoediting: from immunosurveillance to tumor escape Nature Immunology 2002 3 11 991 998 (Pubitemid 35363648)
40. Howie S., McBride W. H., Tumor-specific T helper activity can be abrogated by two distinct suppressor cell mechanisms European Journal of Immunology 1982 12 8 671 675 (Pubitemid 12059279)
41. Spiotto M. T., Fu Y. X., Schreiber H., Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation Current Opinion in Immunology 2003 15 6 725 730 (Pubitemid 37434082)
42. Marks L. B., Hall E. J., Brenner D. J., Extrapolating hypofractionated radiation schemes from radiosurgery data: regarding Hall et al, IJROBP 21:819824; 1991 and Hall and Brenner, IJROBP 25:381385; 1993 International Journal of Radiation Oncology Biology Physics 1995 32 1 274 276
43. Wang J. Z., Huang Z., Lo S. S., Yuh W. T. C., Mayr N. A., A generalized linear-quadratic model for radiosurgery, stereotactic body radiation therapy, and high-dose rate brachytherapy Science Translational Medicine 2010 2 39
44. Hadziahmetovic M., Loo B. W., Timmerman R. D., Mayr N. A., Wang J. Z., Huang Z., Grecula J. C., Lo S. S., Stereotactic body radiation therapy (stereotactic ablative radiotherapy) for stage I non-small cell lung cancerupdates of radiobiology, techniques, and clinical outcomes Discovery medicine 2010 9 48 411 417
45. Cho J., Kodym R., Seliounine S., Richardson J. A., Solberg T. D., Story M. D., High dose-per-fraction irradiation of limited lung volumes using an image-guided, highly focused irradiator: simulating stereotactic body radiotherapy regimens in a small-animal model International Journal of Radiation Oncology Biology Physics 2010 77 3 895 902
46. Wong J., Armour E., Kazanzides P., Iordachita I., Tryggestad E., Deng H., Matinfar M., Kennedy C., Liu Z., Chan T., Gray O., Verhaegen F., McNutt T., Ford E., DeWeese T. L., High-resolution, small animal radiation research platform with X-ray tomographic guidance capabilities International Journal of Radiation Oncology Biology Physics 2008 71 5 1591 1599 (Pubitemid 351978175)
47. Finkelstein S. E., Trotti A., Rao N., The Florida Melanoma Trial I: a prospective multi-center phase I/II trial of post operative hypofractionated adjuvant radiotherapy with concurrent interferon- -2b immunotherapy in the treatment of advanced stage III melanoma with long term toxicity follow up. ISRN Immunology. In press
48. Finkelstein S. E., Iclozan C., Bui M. M., Cotter M. J., Ramakrishnan R., Ahmed J., Noyes D. R., Cheong D., Gonzalez R. J., Heysek R. V., Berman C., Lenox B. C., Janssen W., Zager J. S., Sondak V. K., Letson G. D., Antonia S. J., Gabrilovich D. I., Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients. International Journal of Radiation Oncology, Biology, Physics. In press