Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: The role of endothelial nitric oxide synthase

Clinical and Experimental Pharmacology and Physiology

Volumn 39, Issue 1, 2012, Pages 20-27

  Lv, Lei ^a   Jiang, Shi Sen ^a   Xu, Jun ^a   Gong, Jian Bin ^a   Cheng, Yan ^a  

^a JINLING HOSPITAL   (China)

Author keywords

Apoptosis; Endothelial nitric oxide synthase; Ischaemia reperfusion injury; Ligustrazine; Signal transduction pathways

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; PROTEIN KINASE B; TETRAMETHYLPYRAZINE; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALS; APOPTOSIS; CARDIOTONIC AGENTS; CASPASE 3; ENZYME INHIBITORS; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZINES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SERINE; SIGNAL TRANSDUCTION;

EID: 84855169800     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2011.05628.x     Document Type: Article

References (41)

1. Guo SK, Chen KJ, Qian ZH, Weng WL, Qian MY. Tetramethylpyrazine in the treatment of cardiovascular and cerebrovascular diseases. Planta Med. 1983; 47: 89.
2. Feng L, Ke N, Cheng F et al. The protective mechanism of ligustrazine against renal ischaemia/reperfusion injury. J. Surg. Res. 2011; 166: 298-305.
3. Zhang XP, Wang C, Wu DJ, Ma ML, Ou JM. Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis. Methods Find. Exp. Clin. Pharmacol. 2010; 32: 631-44.
4. Wan JY, Ye DY, Wu P, Zhang L, Gong X, Huang Y. Effect of tetramethylpyrazine on lipopolysaccharides induced macrophage cyclo-oxidase-2 expression and apoptosis of cardiac myocytes. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004; 24: 906-11.(in Chinese).
5. Gao S, Chen ZW, Zheng H, Chen XL. Ligustrazine attenuates acute myocardium injury after thermal trauma. Burns 2007; 33: 321-7.
6. Eefting F, Rensing B, Wigman J et al. Role of apoptosis in reperfusion injury. Cardiovasc. Res. 2004; 61: 414-26.
7. Phillips L, Toledo AH, Lopez-Neblina F, Anaya-Prado R, Toledo-Pereyra LH. Nitric oxide mechanism of protection in ischaemia and reperfusion injury. J. Invest. Surg. 2009; 22: 46-55.
8. Jones SP, Bolli R. The ubiquitous role of nitric oxide in cardioprotection. J. Mol. Cell. Cardiol. 2006; 40: 16-23.
9. Borutaite V, Morkuniene R, Arandarcikaite O, Jekabsone A, Barauskaite J, Brown GC. Nitric oxide protects the heart from ischaemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release. J. Biomed. Sci. 2009; 16: 70.
10. Iwase H, Robin E, Guzy RD et al. Nitric oxide during ischaemia attenuates oxidant stress and cell death during ischaemia and reperfusion in cardiomyocytes. Free Radic. Biol. Med. 2007; 43: 590-9.
11. Kelly RA, Balligand JL, Smith TW. Nitric oxide and cardiac function. Circ. Res. 1996; 79: 363-80.
12. Lepic E, Burger D, Lu X, Song W, Feng Q. Lack of endothelial nitric oxide synthase decreases cardiomyocyte proliferation and delays cardiac maturation. Am. J. Physiol. Cell Physiol. 2006; 291: C1240-6.
13. Kang Y, Hu M, Zhu Y, Gao X, Wang MW. Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells. Life Sci. 2009; 84: 428-36.
14. Shao Z, Li J, Zhao Z, Gao C, Sun Z, Liu X. Effects of tetramethylpyrazine on nitric oxide/cGMP signalling after cerebral vasospasm in rabbits. Brain Res. 2010; 1361: 67-75.
15. Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM. Postconditioning: A form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ. Res. 2004; 95: 230-2.
16. Ludbrook J. On making multiple comparisons in clinical and experimental pharmacology and physiology. Clin. Exp. Pharmacol. Physiol. 1991; 18: 379-92.
17. Hutter R, Valdiviezo C, Sauter BV et al. Caspase-3 and tissue factor expression in lipid-rich plaque macrophages: Evidence for apoptosis as link between inflammation and atherothrombosis. Circulation 2004; 109: 2001-8.
18. Michell BJ, Griffiths JE, Mitchelhill KI et al. The Akt kinase signals directly to endothelial nitric oxide synthase. Curr. Biol. 1999; 9: 845-8.
19. Kim EY, Kim JH, Rhyu MR. Endothelium-independent vasorelaxation by Ligusticum wallichii in isolated rat aorta: Comparison of a butanolic fraction and tetramethylpyrazine, the main active component of Ligusticum wallichii. Biol. Pharm. Bull. 2010; 33: 1360-3.
20. Wong KL, Wu KC, Wu RS, Chou YH, Cheng TH, Hong HJ. Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells. Am. J. Chin. Med. 2007; 35: 1021-35.
21. Murphy E, Steenbergen C. Mechanisms underlying acute protection from cardiac ischaemia-reperfusion injury. Physiol. Rev. 2008; 88: 581-609.
22. Dhalla NS, Elmoselhi AB, Hata T, Makino N. Status of myocardial antioxidants in ischaemia-reperfusion injury. Cardiovasc. Res. 2000; 47: 446-56.
23. Chen SY, Hsiao G, Hwang HR, Cheng PY, Lee YM. Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischaemia/reperfusion injury in rats. J. Biomed. Sci. 2006; 13: 731-40.
24. Zhou Y, Hu CP, Deng PY, Deng HW, Li YJ. The protective effects of ligustrazine on ischaemia-reperfusion and DPPH free radical-induced myocardial injury in isolated rat hearts. Planta Med. 2004; 70: 818-22.
25. Feng L, Xiong Y, Cheng F, Zhang L, Li S, Li Y. Effect of ligustrazine on ischaemia-reperfusion injury in murine kidney. Transplant. Proc. 2004; 36: 1949-51.
26. Roubille F, Combes S, Leal-Sanchez J et al. Myocardial expression of a dominant-negative form of Daxx decreases infarct size and attenuates apoptosis in an in vivo mouse model of ischaemia/reperfusion injury. Circulation 2007; 116: 2709-17.
27. Kumar D, Jugdutt BI. Apoptosis and oxidants in the heart. J. Lab. Clin. Med. 2003; 142: 288-97.
28. Liu VW, Huang PL. Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice. Cardiovasc. Res. 2008; 77: 19-29.
29. Rassaf T, Poll LW, Brouzos P et al. Positive effects of nitric oxide on left ventricular function in humans. Eur. Heart J. 2006; 27: 1699-705.
30. Boyd CS, Cadenas E. Nitric oxide and cell signalling pathways in mitochondrial-dependent apoptosis. Biol. Chem. 2002; 383: 411-23.
31. Berges A, Van Nassauw L, Timmermans JP, Vrints C. Time-dependent expression pattern of nitric oxide and superoxide after myocardial infarction in rats. Pharmacol. Res. 2007; 55: 72-9.
32. Wildhirt SM, Weismueller S, Schulze C, Conrad N, Kornberg A, Reichart B. Inducible nitric oxide synthase activation after ischaemia/reperfusion contributes to myocardial dysfunction and extent of infarct size in rabbits: Evidence for a late phase of nitric oxide-mediated reperfusion injury. Cardiovasc. Res. 1999; 43: 698-711.
33. West MB, Rokosh G, Obal D et al. Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischaemia/reperfusion injury by preventing mitochondrial permeability transition. Circulation 2008; 118: 1970-8.
34. Bolli R. Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischaemia and preconditioning: An overview of a decade of research. J. Mol. Cell. Cardiol. 2001; 33: 1897-918.
35. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601-5.
36. Matsui T, Tao J, del Monte F et al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischaemia in vivo. Circulation 2001; 104: 330-5.
37. Oikawa M, Yaoita H, Watanabe K, Maruyama Y. Attenuation of cardioprotective effect by postconditioning in coronary stenosed rat heart and its restoration by carvedilol. Circ. J. 2008; 72: 2081-6.
38. Liu HT, Du YG, He JL et al. Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signalling pathways, and suppression of intracellular reactive oxygen species. J. Ethnopharmacol. 2010; 129: 335-43.
39. Calvert JW, Lefer DJ. Myocardial protection by nitrite. Cardiovasc. Res. 2009; 83: 195-203.
40. Yin Z, Gao H, Wang H et al. Ischaemic post-conditioning protects both adult and aged Sprague-Dawley rat heart from ischaemia-reperfusion injury through the phosphatidylinositol 3-kinase-AKT and glycogen synthase kinase-3beta pathways. Clin. Exp. Pharmacol. Physiol. 2009; 36: 756-63.
41. Hausenloy DJ, Yellon DM. Reperfusion injury salvage kinase signalling: Taking a RISK for cardioprotection. Heart Fail. Rev. 2007; 12: 217-34.