Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition

Circulation

Volumn 118, Issue 19, 2008, Pages 1970-1978

  West, Matthew B ^a,b   Rokosh, Gregg ^a   Obal, Detlef ^d,e   Velayutham, Murugesan ^b   Xuan, Yu Ting ^a   Hill, Bradford G ^a,b   Keith, Rachel J ^a   Schrader, Jürgen ^e   Guo, Yiru ^a   Conklin, Daniel J ^a   Prabhu, Sumanth D ^a,c   Zweier, Jay L ^f   Bolli, Roberto ^a   Bhatnagar, Aruni ^a,d  

^a Institute of Molecular Cardiology

^b Department of Biochemistry and Molecular Biology ^*

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d University of Louisville School of Medicine   (United States)

^e HEINRICH HEINE UNIVERSITY   (Germany)

^f OHIO STATE UNIVERSITY   (United States)

Author keywords

Infarction; Ischemia; Nitric oxide; Nitric oxide synthase

Indexed keywords

ATRACTYLOSIDE; CYCLOSPORIN A; CYTOCHROME C; DIETHYLENETRIAMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MYOSIN HEAVY CHAIN ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE; NITRIC OXIDE DONOR; OXYGEN RADICAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME RELEASE; EX VIVO STUDY; HEART CONTRACTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MITOCHONDRIAL PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ELECTRON SPIN RESONANCE SPECTROSCOPY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE II; PERFUSION; POLYAMINES; REACTIVE OXYGEN SPECIES; SPERMINE;

EID: 57149142916     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.791533     Document Type: Article

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