Evaluation of the influence of ionization states and spacers in the thermotropic phase behaviour of amino acid-based cationic lipids and the transfection efficiency of their assemblies

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 364-373

  Sarker, Satya Ranjan ^a   Arai, Satoshi ^a   Murate, Motohide ^b   Takahashi, Hiroshi ^c   Takata, Masaki ^d   Kobayashi, Toshihide ^b   Takeoka, Shinji ^a  

^a WASEDA UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c GUNMA UNIVERSITY   (Japan)

^d SPring 8 Center ^*  (Japan)

Author keywords

Cationic lipid; Hydrocarbon chain spacer; Ionization states; Phase transition temperature; Transfection efficiency

Indexed keywords

AMIDE; AMINO ACID; AMMONIUM CHLORIDE; CATION; CHLORINE; HYDROCARBON; LIPID; LIPOFECTAMINE; LIPOSOME; LYSINE; SODIUM CHLORIDE;

ARTICLE; ATOM; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; GENE TARGETING; GENETIC TRANSFECTION; HYDROPHILICITY; HYDROPHOBICITY; IONIZATION; LIQUID CRYSTAL; MICELLE; PHASE TRANSITION; PRIORITY JOURNAL; TRANSITION TEMPERATURE; ZETA POTENTIAL;

AMMONIUM CHLORIDE; ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CATIONS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; GENES, REPORTER; HYDROCARBONS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; LUCIFERASES; LYSINE; MICELLES; MOLECULAR STRUCTURE; PHASE TRANSITION; PLASMIDS; TRANSFECTION; TRANSITION TEMPERATURE;

EID: 84655167074     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.044     Document Type: Article

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