In vivo imaging and spectroscopy of dynamic metabolism using simultaneous 13C and 1H MRI

IEEE Transactions on Biomedical Engineering

Volumn 59, Issue 1, 2012, Pages 45-49

  Smith, Matthew R ^a   Peterson, Eric T ^a   Gordon, Jeremy W ^a   Niles, David J ^a   Rowland, Ian J ^a   Kurpad, Krishna N ^a   Fain, Sean B ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Gadolinium; intracellular; magnetic resonance (MR); metabolism; pyruvate

Indexed keywords

CONTRAST AGENT; HYPERPOLARIZED; IN-VIVO; IN-VIVO IMAGING; INTRACELLULAR; INTRACELLULAR COMPARTMENTS; INTRACELLULAR SPACES; KINETIC MODELING; KINETIC MODELS; METABOLIC RATES; NOVEL TECHNIQUES; PYRUVATES; SEQUENTIAL INJECTION; SIMULTANEOUS ACQUISITION;

CHELATION; GADOLINIUM; KINETIC THEORY; KINETICS; METABOLISM; PHYSIOLOGY;

MAGNETIC RESONANCE;

CONTRAST MEDIUM; GADOLINIUM CHELATE; PYRUVIC ACID;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL COMPARTMENTALIZATION; DYNAMICS; IN VIVO STUDY; INTRACELLULAR SPACE; MEASUREMENT; METABOLIC RATE; MODEL; NONHUMAN; PROCEDURES; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; METABOLIC CLEARANCE RATE; PROTONS; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84555190713     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2011.2161988     Document Type: Article

References (17)

1. A. P. Chen, M. J. Albers, C. H. Cunningham, S. J. Kohler, Y. F. Yen, R. E. Hurd, J. Tropp, R. Bok, J. M. Pauly, S. J. Nelson, J. Kurhanewicz, and D. B. Vigneron, "Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience," Magn. Reson. Med., vol. 58, no. 6, pp. 1099-1106, 2007. (Pubitemid 350234196)
2. S. Hu, A. P. Chen, M. L. Zierhut, R. Bok, Y. F. Yen, M. A. Schroeder, R. E. Hurd,S.J.Nelson,J.Kurhanewicz, andD.B.Vigneron, "In vivo carbon-13 dynamic MRS and MRSI of normaland fasted rat liver with hyperpolarized (13)C-pyruvate," Mol. Imaging Biol., vol. 11, no. 6, pp. 399-407, 2009.
3. S. Hu, M. Lustig, A. P. Chen, J. Crane, A. Kerr, D. A. Kelley, R. Hurd, J. Kurhanewicz, S. J. Nelson, J. M. Pauly, and D. B. Vigneron, "Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI," J. Magn. Reson., vol. 192, no. 2, pp. 258-264, 2008.
4. S. E. Day, M. I. Kettunen, F. A. Gallagher, D. E. Hu, M. Lerche, J. Wolber, K. Golman, J. H. Ardenkjaer-Larsen, and K. M. Brindle, "Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy," Nat. Med., vol. 13, no. 11, pp. 1382-1387, 2007. (Pubitemid 350073590)
5. M. L. Zierhut, Y.-F. Yen, A. P. Chen, R. Bok, M. J. Albers, V. Zhang, J. Tropp, I. Park, D. B. Vigneron, J. Kurhanewicz, R. E. Hurd, and S. J. Nelson, "Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice," J. Magn. Reson., vol. 202, no. 1, pp. 85-92, 2010.
6. T. Harris, G. Eliyahu, L. Frydman, and H. Degani, "Kinetics of hyperpo-larized 13C1-pyruvate transport and metabolism in living human breast cancer cells," Proc. Nat. Acad. Sci., vol. 106, no. 43, pp. 18131-18136, 2009.
7. C. Weidensteiner, M. Horn, E. Fekete, S. Neubauer, and M. von Kienlin, "Imaging of intracellular sodium with shift reagent aided 23Na CSI in isolated rat hearts," Magn. Reson. Med., vol. 48, no. 1, pp. 89-96, 2002. (Pubitemid 34721591)
8. P. E. Larson, R. Hurd, A. Kerr, R. Bok, J. Kurhanewicz, and D. B. Vigneron, "Hyperpolarized 13C 3D metabolic imaging with stimulated echoes for flow suppression," in Proc. Int. Soc. Magn. Reson. Med., 2010, p. 2410.
9. J. H. Ardenkjær-Larsen, B. Fridlund, A. Gram, G. Hansson, L. Hansson, M. H. Lerche, R. Servin, M. Thaning, and K. Golman, "Increase in signal-to-noise ratio of >10000 times in liquid-state NMR," Proc. Nat. Acad. Sci. United States America, vol. 100, no. 18, pp. 10158-10163, 2003. (Pubitemid 37071849)
10. A. Comment, B. van den Brandt, K. Uffmann, F. Kurdzesau, S. Jannin, J. A. Konter, P. Hautle, W. T. Wenckebach, R. Gruetter, and J. J. van der Klink, "Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner," Concepts Magn. Reson. Part B: Magn. Reson. Eng., vol. 31B, no. 4, pp. 255-269, 2007.
11. G. O. Cron, G. Santyr, and F. Kelcz, "Accurate and rapid quantitative dynamic contrast-enhanced breast MR imaging using spoiled gradient-recalled echoes and bookend T1 measurements," Magn. Reson. Med., vol. 42, no. 4, pp. 746-753, 1999. (Pubitemid 29468305)
12. C. Gabellieri, M. O. Leach, and T. R. Eykyn, "Modulating the relaxivity of hyperpolarized substrates with gadolinium contrast agents," Contrast Media Molecular Imag., vol. 4, no. 3, pp. 143-147, 2009.
13. L. C. Bell, E. T. Peterson, J. W. Gordon, S. B. Fain, and K. N. Kurpad, "Dual-tuned 1H/13C orthogonal double solenoid volume coil for simultaneous acquisition in small animals in vivo," in Proc Int. Soc. Magn. Reson. Med., 2010, p. 7112.
14. F. J. Harris, "On the use of windows for harmonic analysis with the discrete Fourier transform," Proc. IEEE, vol. 66, no. 1, pp. 51-83, 1978. (Pubitemid 8338069)
15. L. Chen, Z. Weng, L. Goh, and M. Garland, "An efficient algorithm for automatic phase correction of NMR spectra based on entropy minimization," J. Magn. Reson., vol. 158, no. 1-2, pp. 164-168, 2002.
16. E. T. Peterson, K. Wang, K. N. Kurpad, M. Erickson, I. J. Rowland, and S. B. Fain, "Simultaneous proton and hyperpolarized carbon imaging," in Proc Int. Soc. Magn. Reson. Med., 2011, p. 449.
17. C. Yang, G. S. Karczmar, M. Medved, and W. M. Stadler, "Estimating the arterial input function using two reference tissues in dynamic contrast-enhanced MRI studies: Fundamental concepts and simulations," Magn. Reson. Med., vol. 52, no. 5, pp. 1110-1117, 2004. (Pubitemid 39453285)