Aging, inflammation, and emphysema

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 12, 2011, Pages 1327-1329

  Macnee, William ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; SIRTUIN 1;

AGING; CHRONIC OBSTRUCTIVE LUNG DISEASE; EDITORIAL; EMPHYSEMA; HUMAN; INFLAMMATION; LUNG ENDOTHELIUM; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SMOKING CESSATION; TELOMERE;

ANIMALS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; INFLAMMATION; MALE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; TELOMERE SHORTENING;

EID: 84455204892     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201110-1764ED     Document Type: Editorial

References (20)

1. MacNee W. Pathogenisis of chronic obstructive pulmonary disease. Clin Chest Med 2007;28:479-513. (Pubitemid 47284592)
2. Niewoehner DE, Kleinerman J, Rice DB. Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med 1974;291:755-758.
3. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645-2653. (Pubitemid 38787999)
4. MacNee W. Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD). Biochem Soc Trans 2009;37:819-823.
5. Karrasch S, Holz O, Jorres RA. Aging and induced senescence as factors in the pathogenesis of lung emphysema. Respir Med 2008;102:1215-1230.
6. Saretzki G, von Zglinicki T. Replicative aging, telomeres, and oxidative stress. Ann N Y Acad Sci 2002;959:24-29. (Pubitemid 34457548)
7. Babizhayev MA, Savel'yeva EL, Moskvina SN, Yegorov YE. Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior. Am J Ther (In press)
8. Morlá M, Busquets X, Pons J, Sauleda J, MacNee W, Agustí AG. Telomere shortening in smokers with and without COPD. Eur Respir J 2006;27:525-528. (Pubitemid 43372526)
9. Tsuji T, Aoshiba K, Nagal A. Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med 2006;174:886-893. (Pubitemid 44564788)
10. Müller KC, Welker L, Paasch K, Feindt B, Erpenbeck VJ, Hohlfeld JM, Krug N, Nakashima M, Branscheid D, Magnussen H, et al. Lung fibroblasts from patients with emphysema show markers of senescence in vitro. Respir Res 2006;7:32.
11. Savale L, Chaouat A, Bastuji-Garin S, Marcos E, Boyer L, Maitre B, Sarni M, Housset B, Weitzenblum E, Matrat M, et al. Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009;179:566-571.
12. Houben JM, Mercken EM, Ketelslegers HB, Bast A, Wouters EF, Hageman GJ, Schols AM. Telomere shortening in chronic obstructive pulmonary disease. Respir Med 2009;103:230-236.
13. Aviv A. Telomeres and human aging: facts and fibs. Sci SAGE KE 2004;2004:pe43.
14. Stein GH, Drullinger LF, Soulard A, Dulić V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 1999;19:2109-2117. (Pubitemid 29098269)
15. Marwick JA, Kirkham PA, Stevenson CS, Danahay H, Giddings J, Butler K, Donaldson K, MacNee W, Rahman I. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. Am J Respir Cell Mol Biol 2004;31:633-642. (Pubitemid 39587493)
16. Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am J Physiol Lung Cell Mol Physiol 2007;292:L567-L576.
17. Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I. SIRT1, an anti-inflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008;177:861-870. (Pubitemid 351600664)
18. Kazutetsu A, Nagai A. Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009;6:596-601.
19. Amsellem V, Gary-Bobo G, Marcos E, Maitre B, Chaar V, Validire P, Stern J-B, Noureddine H, Sapin E, Rideau D, et al. Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 184;1358-1366.
20. Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, Armanios M. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med 2011;184:904-912.