Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior

American Journal of Therapeutics

Volumn 18, Issue 6, 2011, Pages

  Babizhayev, Mark A ^a,b   Savel'yeva, Ekaterina L ^c   Moskvina, Svetlana N ^d   Yegorov, Yegor E ^e  

^a Innovative Vision Products Inc   (Russian Federation)

^b MOSCOW HELMHOLTZ RESEARCH INSTITUTE OF EYE DISEASES   (Russian Federation)

^c PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

^d N N BLOKHIN NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY   (Russian Federation)

^e ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

biologic aging; cancer and chronic obstructive pulmonary diseases; cardiovascular diseases; cumulative oxidative stress; inflammation; predictor of survival and therapeutic treatment requirement associated with smoking; telomere attrition (expressed in white blood cells); telomere length; tobacco smoking

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CARCININE; CARNOSINE; CATECHOL; CIGARETTE SMOKE; COTININE; FIBRINOGEN; FREE RADICAL; GLUTATHIONE; GLUTATHIONE DISULFIDE; HISTAMINE DERIVATIVE; HYDROQUINONE; NICOTINE; REACTIVE OXYGEN METABOLITE; THROMBIN; UNCLASSIFIED DRUG;

AGE; ARTICLE; CANCER RISK; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CIGARETTE SMOKING; DNA DAMAGE; ENDOTHELIUM CELL; FIBRINOGEN BLOOD LEVEL; HUMAN; IMMUNOSTIMULATION; INFLAMMATION; LEUKOCYTE; LIFESPAN; LONGEVITY; LUNG LAVAGE; NEUTROPHIL; NONHUMAN; OBESITY; OXIDATIVE STRESS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL RATE; TELOMERE; TELOMERE LENGTH;

ADOLESCENT; ADULT; AGED; AGING; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; FEMALE; FREE RADICALS; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKE; SMOKING; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING; TOBACCO; TOBACCO PRODUCTS; YOUNG ADULT;

EID: 81755161387     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e3181cf8ebb     Document Type: Article

References (144)

1. Hatsukami DK, Stead LF, Gupta PC. Tobacco addiction. Lancet. 2008;371:2027-2038. (Pubitemid 351799860)
2. The Office of Tobacco Control (OTC). Press Release May 2004. Dublin, Ireland: The Office of Tobacco Control, Department of Health and Children; 2004.
3. Cokkinides V, Bandi P, McMahon C, et al. Tobacco control in the United States-recent progress and opportunities. CA Cancer J Clin. 2009;59:352-365.
4. McNabola A, Gill LW. The control of environmental tobacco smoke: a policy review. Int J Environ Res Public Health. 2009;6:741-758.
5. Meyers DG, Neuberger JS. Cardiovascular effect of bans on smoking in public places. Am J Cardiol. 2008; 102:1421-1424.
6. Nakamura K, Huxley R, Ansary-Moghaddam A, et al. The hazards and benefits associated with smoking and smoking cessation in Asia: a meta-analysis of prospective studies. Tob Control. 2009;18:345-353.
7. O'Flaherty M, Bishop J, Redpath A, et al. Coronary heart disease mortality among young adults in Scotland in relation to social inequalities: time trend study. BMJ. 2009;339:b2613. doi: 10.1136/bmj.b2613.
8. Gupta R. Recent trends in coronary heart disease epidemiology in India. Indian Heart J. 2008;60(2 Suppl B): B4-B18.
9. Csiszar A, Podlutsky A,Wolin MS, et al. Oxidative stress and accelerated vascular aging: implications for cigarette smoking. Front Biosci. 2009;14:3128-3144.
10. Alberg AJ. Cigarette smoking: health effects and control strategies. Drugs Today (Barc). 2008;44:895-904.
11. Santini F, Casali G, Lusini M, et al. Mid-term results after extensive vein patch reconstruction and internal mammary grafting of the diffusely diseased left anterior descending coronary artery. Eur J Cardiothorac Surg. 2002; 21:1020-1025.
12. Lyons MJ, Gibson JK, Ingram DJE. Free radicals produced in cigarette smoke. Nature. 1958;181:1003-1004.
13. Ingram DJE. Electron resonance studies of the free radicals produced in tobacco pyrolysis and in other related compounds. Acta Med Scand. 1961;369(Suppl):43-61.
14. Tully GW, Briggs, CD, Horsfield A. E.P.R. absorption by the vapour phase of cigarette smoke, condensed and examined at low temperature. Chem Ind (Lond). 1969;7: 201-203.
15. Bluhm AL, Weinstein J, Sousa, JA. Free radicals in tobacco smoke. Nature. 1971;229:500.
16. de Hys LS, Francis HE, Seeback GL, et al. Electron spin resonance spin trapping studies of cigarette smoke. Proc Tobacco Health Workshop Conf (UnivKentucky, Lexington, KY). 1973:474-483.
17. Menzel ER, Vincent WR,Wasson JR. Dipolar broadening of electron spin resonance lines of free radicals: spin trapping studies of free radicals in cigarette smoke. J Magn Res. 1976;21:321-330.
18. PryorWA, Terauchi K, DavisWH. Electron spin resonance (ESR) study of cigarette smoke by use of spin trapping techniques. Environ Health Perspect. 1976;16:161-176.
19. Lyons MJ, Spence JB. Environmental free radicals. Br J Cancer. 1960;14:703-708.
20. PryorWA, Prier DG, Church DF. Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar. Environ Health Perspect. 1983;47:345-355. (Pubitemid 13134676)
21. Zang LY, Stone K, PryorWA. Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance. Free Radic Biol Med. 1995;19:161-167.
22. Hecht SS, Carmella S, Mori H, et al. A study of tobacco carcinogenesis. XX. Role of catechol as a major cocarcinogen in the weakly acidic fraction of smoke condensate. J Natl Cancer Inst. 1981;66:163-169. (Pubitemid 11163250)
23. Cadenas E, Boveris A, Ragan CI, et al. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef heart mitochondria. Arch Biochem Biophys. 1977;180:248-257. (Pubitemid 8115490)
24. Bachur NR, Gordon SL, Gee MV. A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res. 1978;38:1745-1750. (Pubitemid 8349723)
25. Morgenstern R, DePierre JW, Lind C, et al. Benzo(a)pyrene quinines can be generated by lipid peroxidation. Biochem Biophys Res Commun. 1981;99:682-690.
26. Nagata C, Kodama M, Ioki Y. Electron spin resonance study of the binding of the 6-oxybenzo(a)pyrene radical and benzo(a)pyrene-semiquinone radicals with DNA and polynucleotides. In: Gelboinj HV, Ts'o POP, eds. Polycyclic Hydrocarbons and Cancer. Vol. I. Chapt. 12. New York: Academic Press; 1978.
27. Zang LY, Stone K, PryorWA. Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance. Free Radic Biol Med. 1995;19:161-167.
28. Stone KK, Bermúdez E, Pryor WA. Aqueous extracts of cigarette tar containing the tar free radical cause DNA nicks in mammalian cells. Environ Health Perspect. 1994; 102(Suppl 10):173-178.
29. Borish ET, Cosgrove JP, Church DF, et al. Cigarette tar causes single-strand breaks in DNA. Biochem Biophys Res Commun. 1985;133:780-786. (Pubitemid 16103913)
30. Borish ET, Pryor WA, Venugopal S, et al. DNA synthesis is blocked by cigarette tar-induced DNA single-strand breaks. Carcinogenesis. 1987;8:1517-1520. (Pubitemid 18045810)
31. Valavanidis A, Vlachogianni T, Fiotakis C. 8-Hydroxy-2'- deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009;27:120-139.
32. Leanderson P, Tagesson C. Cigarette smoke-induced DNA-damage: role of hydroquinone and catechol in the formation of the oxidative DNA-adduct, 8-hydroxydeoxyguanosine. Chem Biol Interact. 1990;75:71-81. (Pubitemid 20199718)
33. Pattison DI, Davies MJ, Levina A, et al. Chromium(VI) reduction by catechol(amine)s results in DNA cleavage in vitro: relevance to chromium genotoxicity. Chem Res Toxicol. 2001;14:500-510. (Pubitemid 32480017)
34. Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol. 2004;43:1731-1737. (Pubitemid 38622506)
35. Squadrito GL, Cueto R, Dellinger B, et al. Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter. Free Radic Biol Med. 2001;31:1132-1138. (Pubitemid 33009320)
36. Brockmann MA, Beythien C, Magens MM, et al. Platelet hemostasis capacity in smokers. In vitro function analyses with 3.2% citrated whole blood. Thromb Res. 2001;104:333-342. (Pubitemid 33152954)
37. Hjemdahl P. Smoking, nicotine and thrombotic risk- a role for platelet dependent thrombin generation? Eur Heart J. 2001;22:16-18. Comment on: Eur Heart J. 2001;22: 56-61. (Pubitemid 32622184)
38. Benowitz NL, Gourlay SG. Cardiovascular toxicity of nicotine: implications for nicotine replacement therapy. J Am Coll Cardiol. 1997;29:1422-1431. (Pubitemid 27272432)
39. FitzGerald GA, Oates JA, Nowak J. Cigarette smoking and hemostatic function. Am Heart J. 1988;115:267-271. (Pubitemid 18028712)
40. Wennmalm A, Benthin G, Granström EF, et al. Maintained hyperexcretion of thromboxane A2 metabolite in healthy young cigarette smokers: results from a prospective study in randomly sampled males with stable smoking habits. Clin Physiol. 1993;13:257-264. (Pubitemid 23170644)
41. Dotevall A, Rångemark C, Eriksson E, et al. Cigarette smoking increases thromboxane A2 formation without affecting platelet survival in young healthy females. Thromb Haemost. 1992;68:583-588.
42. Saareks V, Riutta A, Mucha I, et al. Nicotine and cotinine modulate eicosanoid production in human leukocytes and platelet rich plasma. Eur J Pharmacol. 1993;248: 345-349.
43. Fuster V, Chesebro JH, Frye RL, et al. Platelet survival and the development of coronary artery disease in the young adult: effects of cigarette smoking, strong family history and medical therapy. Circulation. 1981;63:546-551. (Pubitemid 11139862)
44. Mundal HH, Hjemdahl P, Gjesdal K. Acute effects of cigarette smoking on platelet function and plasma catecholamines in hypertensive and normotensive men. Am J Hypertens. 1998;11:677-681. (Pubitemid 28313686)
45. Hioki Y, Aoki N, Kawano K. Acute effects of smoking on platelet-dependent thrombin generation. Eur Heart J. 2000;21:54-59.
46. Kimura S, Nishinaga M, Ozawa T, et al. Thrombin generation as an acute effect of cigarette smoking. Am Heart J. 1994;128:7-11. (Pubitemid 24227129)
47. Churg A. Interactions of exogenous or evoked agents and particles: the role of reactive oxygen species. Free Radic Biol Med. 2003;34:1230-1235. (Pubitemid 36513965)
48. Bock FG, Swain AP, Stedman RL. Carcinogenesis assay of subfractions of cigarette smoke condensate prepared by solvent-solvent separation of the neutral fraction. J Natl Cancer Inst. 1972;49:477-483.
49. Schmeltz I, Stills CD, Chamberlain WJ, et al. Analysis of cigarette smoke fraction by combined gas chromatography- infrared spectrophotometry. Anal Chem. 1965;37:1614-1616.
50. Swain AP, Cooper JE, Stedman RL. Large-scale fractionation of cigarette smoke condensate for chemical and biologic investigations. Cancer Res. 1969;29:579-583.
51. Raij L, DeMaster EG, Jaimes EA. Cigarette smokeinduced endothelium dysfunction: role of superoxide anion. J Hypertens. 2001;19:891-897. (Pubitemid 32436953)
52. Celermajer DS, Sorensen KE, Bull C, et al. Endotheliumdependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol. 1994;24:1468-1474. (Pubitemid 24344241)
53. Celermajer DS, Sorensen KE, Georgakopoulos D, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endotheliumdependent dilation in healthy young adults. Circulation. 1993;88:2149-2155. (Pubitemid 23326094)
54. Orosz Z, Csiszar A, Labinskyy N, et al. Cigarette smokeinduced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation. Am J Physiol Heart Circ Physiol. 2007;292:H130-H139. (Pubitemid 46105172)
55. Czernin J, Sun K, Brunken R, et al. Effect of acute and long-term smoking on myocardial blood flow and flow reserve. Circulation. 1995;91:2891-2897.
56. Fennessy FM, Moneley DS, Wang JH, et al. Taurine and vitamin C modify monocyte and endothelial dysfunction in young smokers. Circulation. 2003;107:410-415. (Pubitemid 36158042)
57. Jaimes EA, DeMaster EG, Tian RX, et al. Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation. Arterioscler Thromb Vasc Biol. 2004;24:1031-1036. (Pubitemid 38737827)
58. Nagy J, Demaster EG, Wittmann I, et al. Induction of endothelial cell injury by cigarette smoke. Endothelium. 1997;5:251-263. (Pubitemid 28177010)
59. Raveendran M, Wang J, Senthil D, et al. Endogenous nitric oxide activation protects against cigarette smoking induced apoptosis in endothelial cells. FEBS Lett. 2005; 579:733-740.
60. Dovgan PS, Edwards JD, Zhan X, et al. Cigarette smoking increases monocyte adherence to cultured endothelial cell monolayer. Biochem Biophys Res Commun. 1994;203:929-934. (Pubitemid 24304918)
61. Kalra VK, Ying Y, Deemer K, et al. Mechanism of cigarette smoke condensate induced adhesion of human monocytes to cultured endothelial cells. J Cell Physiol. 1994;160:154-162. (Pubitemid 24214046)
62. Bergmann S, Siekmeier R, Mix C, et al. Even moderate cigarette smoking influences the pattern of circulating monocytes and the concentration of sICAM-1. Respir Physiol. 1998;114:269-275. (Pubitemid 29050874)
63. Shen Y, Rattan V, Sultana C, et al. Cigarette smoke condensate-induced adhesion molecule expression and transendothelial migration of monocytes. Am J Physiol. 1996;270:H1624-H1633.
64. Nakamura Y, Romberger DJ, Tate L, et al. Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis. Am J Respir Crit Care Med. 1995;151:1497-1503.
65. Kuschner WG, D'Alessandro A, Wong H, et al. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J. 1996;9: 1989-1994. (Pubitemid 26333532)
66. Hunninghake GW, Crystal RG. Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers. Am Rev Respir Dis. 1983;128: 833-838. (Pubitemid 14231334)
67. van Eeden SF, Hogg JC. The response of human bone marrow to chronic cigarette smoking. Eur Respir J. 2000; 15:915-921. (Pubitemid 30321851)
68. Morrison D, Rahman I, Lannan S, et al. Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Am J Respir Crit Care Med. 1999;159: 473-479. (Pubitemid 29084868)
69. Janoff A, Raju L, Dearing R. Levels of elastase activity in bronchoalveolar lavage fluids of healthy smokers and nonsmokers. Am Rev Respir Dis. 1983;127:540-544. (Pubitemid 13087057)
70. Hockertz S, Emmendö rffer A, Scherer G, et al. Acute effects of smoking and high experimental exposure to environmental tobacco smoke (ETS) on the immune system. Cell Biol Toxicol. 1994;10:177-190. (Pubitemid 24258059)
71. Winkel P, Statland BE. The acute effect of cigarette smoking on the concentrations of blood leukocyte types in healthy young women. Am J Clin Pathol. 1981;75:781-785. (Pubitemid 11063874)
72. Abboud RT, Fera T, Johal S, et al. Effect of smoking on plasma neutrophil elastase levels. J Lab Clin Med. 1986; 108:294-300. (Pubitemid 16003235)
73. Walter S, Nancy NR. Basopenia following cigarette smoking. Indian J Med Res. 1980;72:422-425. (Pubitemid 11223774)
74. Walter S, Walter A. Basophil degranulation induced by cigarette smoking man. Thorax. 1982;37:756-759. (Pubitemid 13250531)
75. van der Vaart H, Postma DS, Timens W, et al. Acute effects of cigarette smoke on inflammation and oxidative stress: a review. Thorax. 2004;59:713-721. (Pubitemid 39061538)
76. Papi A, Romagnoli M, Baraldo S, et al. Partial reversibility of airflow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;162:1773-1777.
77. Saetta M, Di Stefano A, Maestrelli P, et al. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med. 1994;150:1646-1652. (Pubitemid 24361741)
78. Hulbert WC, Walker DC, Jackson A, et al. Airway permeability to horseradish peroxidase in guinea pigs: the repair phase after injury by cigarette smoke. Am Rev Respir Dis. 1981;123:320-326. (Pubitemid 11153193)
79. Chapman JT, Otterbein LE, Elias JA, et al. Carbon monoxide attenuates aeroallergen-induced inflammation in mice. Am J Physiol Lung Cell Mol Physiol. 2001;281: L209-L216.
80. Melgert BN, Postma DS, Geerlings M, et al. Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice. Am J Respir Cell Mol Biol. 2004;30:880-885. (Pubitemid 38736913)
81. Stringer KA, Tobias M, O'Neill HC, et al. Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1572-L1579. (Pubitemid 47077373)
82. Vayssier-Taussat M, Camilli T, Aron Y, et al. Effects of tobacco smoke and benzo[a]pyrene on human endothelial cell and monocyte stress responses. Am J Physiol Heart Circ Physiol. 2001;280:H1293-H1300.
83. Vayssier M, Banzet N, Francxois D, et al. Tobacco smoke induces both apoptosis and necrosis in mammalian cells: differential effects of HSP70. Am J Physiol. 1998;275: L771-L779.
84. Baglole CJ, Bushinsky SM, Garcia TM, et al. Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. Am J Physiol Lung Cell Mol Physiol. 2006;291: L19-L29.
85. Rahman I, Morrison D, Donaldson K, et al. Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med. 1996;154:1055-1060.
86. Montuschi P, Collins JV, Ciabattoni G, et al. Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med. 2000;162:1175-1177.
87. Aoshiba K, Koinuma M, Yokohori N, et al. Immunohistochemical evaluation of oxidative stress in murine lungs after cigarette smoke exposure. Inhal Toxicol. 2003;15: 1029-1038. (Pubitemid 37158653)
88. Rahman I, Smith CA, Lawson MF, et al. Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells. FEBS Lett. 1996;396:21-25. (Pubitemid 26360273)
89. Stewart SA, Weinberg RA. Telomeres: cancer to human aging. Annu Rev Cell Dev Biol. 2006;22:531-557.
90. Shay JW, Wright WE. Telomerase activity in human cancer. Curr Opin Oncol. 1996;8:66-71. (Pubitemid 26093745)
91. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002;27:339-344. (Pubitemid 34756516)
92. Gilley D, Tanaka H, Herbert BS. Telomere dysfunction in aging and cancer. Int J Biochem Cell Biol. 2005;37:1000-1013. (Pubitemid 40311742)
93. Rudolph KL, Chang S, Lee HW, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 1999;96:701-712. (Pubitemid 29122812)
94. Blasco MA, Gasser SM, Lingner J. Telomeres and telomerase. Genes Dev. 1999;13:2353-2359. (Pubitemid 29453605)
95. Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 1997;91:25-34. Comment in: Cell. 1997 Oct 3;91:1-3. (Pubitemid 27431310)
96. Blasco MA, Lee HW, Rizen M, et al. Mouse models for the study of telomerase. Ciba Found Symp. 1997;211:160- 170; discussion 70-76.
97. Blasco MA. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet. 2005;6:611-622. (Pubitemid 41044298)
98. Greider CW. Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci U S A. 1998;95:90-92. (Pubitemid 28103910)
99. Mirabello L, Garcia-Closas M, Cawthon R, et al. Leukocyte telomere length in a population-based casecontrol study of ovarian cancer: a pilot study. Cancer Causes Control. 2010;21:77-82
100. Wu X, Amos CI, Zhu Y, et al. Telomere dysfunction: a potential cancer predisposition factor. J Natl Cancer Inst. 2003;95:1211-1218. Comment in: J Natl Cancer Inst. 2003 Aug 20;95:1184-1186. (Pubitemid 37069551)
101. Kogevinas M, Trichopoulos D. Urinary bladder cancer. In: Adami H-O, Hunter DJ, Trichopoulos D, eds. Textbook of Cancer Epidemiology. New York: Oxford University Press; 2002:446-466.
102. Broberg K, Björk J, Paulsson K, et al. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis. 2005;26:1263-1271. (Pubitemid 41417904)
103. McGrath M,Wong JY, Michaud D, et al. Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol Biomarkers Prev. 2007;16:815-819. (Pubitemid 46650587)
104. Aviv A, Valdes AM, Spector TD. Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol. 2006;35:1424-1429. (Pubitemid 46178916)
105. Bischoff C, Petersen HC, Graakjaer J, et al. No association between telomere length and survival among the elderly and oldest old. Epidemiology. 2006;17:190-194.
106. Aviv A. Telomeres and human aging: facts and fibs. Sci Aging Knowl Environ. 2004;2004:pe43.
107. Cawthon RM, Smith KR, O'Brien E, et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361:393-395. (Pubitemid 36164975)
108. Martin-Ruiz CM, Gussekloo J, van Heemst D, et al. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population- based study. Aging Cell. 2005;4:287-290.
109. Benetos A, Gardner JP, Zureik M, et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension. 2004;43:182-185. (Pubitemid 38174171)
110. Benetos A, Okuda K, Lajemi M, et al. Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension. 2001;37:381-385. (Pubitemid 32198997)
111. Brouilette S, Singh RK, Thompson JR, et al. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol. 2003;23:842-846. (Pubitemid 36566175)
112. Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol. 2007;165: 14-21. (Pubitemid 46026204)
113. Demissie S, Levy D, Benjamin EJ, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell. 2006;5:325-330. (Pubitemid 44103248)
114. Samani NJ, Boultby R, Butler R, et al. Telomere shortening in atherosclerosis. Lancet. 2001;358:472-473. (Pubitemid 32769858)
115. Valdes AM, Andrew T, Gardner JP, et al. Obesity, cigarette smoking, and telomere length in women. Lancet. 2005;366:662-664. (Pubitemid 41176019)
116. Aviv A, Valdes A, Gardner JP, et al. Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation. J Clin Endocrinol Metab. 2006;91:635-640. (Pubitemid 43236936)
117. Gardner JP, Li S, Srinivasan SR, et al. Rise in insulin resistance is associated with escalated telomere attrition. Circulation. 2005;111:2171-2177. (Pubitemid 40632431)
118. von Zglinicki T, Serra V, Lorenz M, et al. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor? Lab Invest. 2000;80:1739-1747.
119. Panossian LA, Porter VR, Valenzuela HF, et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging. 2003;24:77-84. (Pubitemid 35454145)
120. Nawrot TS, Staessen JA, Gardner JP, et al. Telomere length and possible link to X chromosome. Lancet. 2004; 363:507-510. (Pubitemid 38229449)
121. Morlá M, Busquets X, Pons J, et al. Telomere shortening in smokers with and without COPD. Eur Respir J. 2006; 27:525-528. (Pubitemid 43372526)
122. Mayer S, Brü derlein S, Perner S, et al. Sex-specific telomere length profiles and age-dependent erosion dynamics of individual chromosome arms in humans. Cytogenet Genome Res. 2006;112:194-201. (Pubitemid 43260743)
123. Cherif H, Tarry JL, Ozanne SE, et al. Ageing and telomeres: a study into organ- and gender-specific telomere shortening. Nucleic Acids Res. 2003;31:1576-1583. (Pubitemid 36304920)
124. Bischoff C, Graakjaer J, Petersen HC, et al. The heritability of telomere length among the elderly and oldest-old. Twin Res Hum Genet. 2005;8:433-439. (Pubitemid 41499484)
125. Okuda K, Bardeguez A, Gardner JP, et al. Telomere length in the newborn. Pediatr Res. 2002;52:377-381. (Pubitemid 34920268)
126. Epel ES, Blackburn EH, Lin J, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004;101:17312-17315. Comment in: Int J Palliat Nurs. 2009;15:55. Proc Natl Acad Sci U S A. 2004;101: 17323-17324. (Pubitemid 39627816)
127. Toussaint O, Medrano EE, von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol. 2000;35:927-945.
128. Babizhayev MA, Kasus-Jacobi A. Imidazole-containing peptide-based compounds in sight-threatening age-related eye diseases. Expert Rev Ophthalmol. 2009;4:581-586.
129. Babizhayev MA, Micans P, Guiotto A, et al. Nacetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients. Am J Ther. 2009;16: 517-533.
130. Holliday R,McFarland GA. A role for carnosine in cellular maintenance. Biochemistry (Mosc). 2000;65:843-848.
131. McFarland GA, Holliday R. Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp Cell Res. 1994;212:167-175. (Pubitemid 24216690)
132. McFarland GA, Holliday R. Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts. Exp Gerontol. 1999; 34:35-45. (Pubitemid 29085066)
133. Shao L, Li QH, Tan Z. L-Carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem Biophys Res Commun. 2004;324:931-936. (Pubitemid 39345603)
134. Babizhayev MA,Meguro K. Combined use of carnosinase inhibitor with L-carnosines and composition. WO 2004/ 064866 PCT/JP2004/000351. Filed January 20, 2003.
135. American Cancer Society. 12th World Conference on Tobacco or Health. Tobacco Control Profiles. Atlanta, GA: American Cancer Society; 2003.
136. Global Youth Tobacco Survey Collaborating Group. Differences in worldwide tobacco use by gender: findings from the Global Youth Tobacco Survey. J Sch Health. 2003;73:207-215.
137. Hegedius L, Brix TH, Vestergaard P. Relationship between cigarette smoking and Graves' ophthalmopathy. J Endocrinol Invest. 2004;27:265-271. (Pubitemid 38607480)
138. Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 2006;54:38-46. (Pubitemid 43122184)
139. Warren CW, Jones NR, Eriksen MP, et al. Global Tobacco Surveillance System (GTSS) collaborative group: patterns of global tobacco use in young people and implications for future chronic disease burden in adults. Lancet. 2006;367:749-753. (Pubitemid 43326293)
140. American Cancer Society. Cancer Facts and Figures 2007. Atlanta, GA: American Cancer Society; 2007.
141. Koch M, van Harten A, Uyttenboogaart M, et al. Cigarette smoking and progression in multiple sclerosis. Neurology. 2007;69:1515-1520. (Pubitemid 47537858)
142. Hawkes CH. Smoking is a risk factor for multiple sclerosis: a metaanalysis. Mult Scler. 2007;13:610-615. (Pubitemid 46939526)
143. Yegorov YE, Chernov DN, Akimov SS, et al. Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like processes in cultured mouse fibroblasts. FEBS Lett. 1996;389:115-118. (Pubitemid 26226481)
144. Yegorov YE, Akimov SS, Akhmalisheva AK, et al. Blockade of telomerase function in various cells. Anticancer Drug Des. 1999;14:305-316.