Phenotype of the most common "slow acetylator" arylamine N-Acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent

Drug Metabolism and Disposition

Volumn 40, Issue 1, 2012, Pages 198-204

  Millner, Lori M ^a   Doll, Mark A ^a   Cai, Jian ^a   States, J Christopher ^a   Hein, David W ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 BIPHENYLAMINE; ARYLAMINE ACETYLTRANSFERASE; MESSENGER RNA;

ACETYLATION; ACETYLATOR PHENOTYPE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; IN VITRO STUDY; KINETICS; NAT1 14B GENE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ACETYLATION; ANIMALS; ARYLAMINE N-ACETYLTRANSFERASE; CATALYSIS; CHO CELLS; CRICETINAE; GENETIC VARIATION; HUMANS; ISOENZYMES; PHENOTYPE; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 84455194033     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.041855     Document Type: Article

References (41)

1. Adam PJ, Berry J, Loader JA, Tyson KL, Craggs G, Smith P, De Belin J, Steers G, Pezzella F, Sachsenmeir KF, et al. (2003) Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro. Mol Cancer Res 1:826-835. (Pubitemid 37174454)
2. Ambrosone CB, Abrams SM, Gorlewska-Roberts K, and Kadlubar FF (2007) Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells. Arch Biochem Biophys 464:169-175. (Pubitemid 47210937)
3. Barker DF, Husain A, Neale JR, Martini BD, Zhang X, Doll MA, States JC, and Hein DW (2006) Functional properties of an alternative, tissue-specific promoter for human arylamine Nacetyltransferase 1. Pharmacogenet Genomics 16:515-525. (Pubitemid 43922348)
4. Bell DA, Stephens EA, Castranio T, Umbach DM, Watson M, Deakin M, Elder J, Hendrickse C, Duncan H, and Strange RC (1995) Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer. Cancer Res 55:3537-3542.
5. Bendaly J, Zhao S, Neale JR, Metry KJ, Doll MA, States JC, Pierce WM Jr, and Hein DW (2007) 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2. Cancer Epidemiol Biomarkers Prev 16, 1503-1509. (Pubitemid 47076886)
6. Bouchardy C, Mitrunen K, Wikman H, Husgafvel-Pursiainen K, Dayer P, Benhamou S, and Hirvonen A (1998) N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk. Pharmacogenetics 8:291-298. (Pubitemid 28372322)
7. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
8. Butcher NJ, Arulpragasam A, and Minchin RF (2004) Proteasomal degradation of Nacetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation. J Biol Chem 279:22131-22137. (Pubitemid 38679406)
9. Chen Y, Liu L, Nguyen K, and Fretland AJ (2011) Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450. Drug Metab Dispos 39:373-382.
10. Dhaini HR and Levy GN (2000) Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population. Pharmacogenetics 10:79-83. (Pubitemid 30142816)
11. Doll MA and Hein DW (2002) Rapid genotype method to distinguish frequent and/or functional polymorphisms in human N-acetyltransferase-1. Anal Biochem 301:328-332. (Pubitemid 34158198)
12. Eisenthal R, Danson MJ, and Hough DW (2007) Catalytic efficiency and kcat/KM: a useful comparator? Trends Biotechnol 25:247-249. (Pubitemid 46755406)
13. Fretland AJ, Doll MA, Leff MA, and Hein DW (2001) Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1. Pharmacogenetics 11:511-520. (Pubitemid 32778228)
14. Fretland AJ, Doll MA, Zhu Y, Smith L, Leff MA, and Hein DW (2002) Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition. Cancer Detect Prev 26:10-14. (Pubitemid 36087176)
15. Gago-Dominguez M, Bell DA, Watson MA, Yuan JM, Castelao JE, Hein DW, Chan KK, Coetzee GA, Ross RK, and Yu MC (2003) Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2. Carcinogenesis 24:483-489. (Pubitemid 36432644)
16. Hein DW, Doll MA, Fretland AJ, Leff MA, Webb SJ, Xiao GH, Devanaboyina US, Nangju NA, and Feng Y (2000) Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol Biomarkers Prev 9:29-42. (Pubitemid 30062907)
17. Hein DW, Doll MA, Nerland DE, and Fretland AJ (2006) Tissue distribution of Nacetyltransferase 1 and 2 catalyzing the N-acetylation of 4-aminobiphenyl and O-acetylation of N-hydroxy-4-aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster. Mol Carcinog 45:230-238.
18. Hickman D, Palamanda JR, Unadkat JD, and Sim E (1995) Enzyme kinetic properties of human recombinant arylamine N-acetyltransferase 2 allotypic variants expressed in Escherichia coli. Biochem Pharmacol 50:697-703.
19. Hoffmann D, Djordjevic MV, and Hoffmann I (1997) The changing cigarette. Prev Med 26:427-434. (Pubitemid 27314094)
20. Horton RM, Hunt HD, Ho SN, Pullen JK, and Pease LR (1989) Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77:61-68. (Pubitemid 19125654)
21. Hughes NC, Janezic SA, McQueen KL, Jewett MA, Castranio T, Bell DA, and Grant DM (1998) Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe. Pharmacogenetics 8:55-66. (Pubitemid 28097602)
22. Husain A, Barker DF, States JC, Doll MA, and Hein DW (2004) Identification of the major promoter and non-coding exons of the human arylamine N-acetyltransferase 1 gene (NAT1). Pharmacogenetics 14:397-406. (Pubitemid 38971230)
23. IARC (1987) Overall evaluations of carcinogenicity: an updating of IARC Monographs volumes 1 to 42. IARC Monogr Eval Carcinog Risks Hum Suppl 7, 1-440. PMID:3482203.
24. Jensen LE, Hoess K, Whitehead AS, and Mitchell LE (2005) The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida. Birth Defects Res A Clin Mol Teratol 73:512-516. (Pubitemid 41045299)
25. Lammer EJ, Shaw GM, Iovannisci DM, Van Waes J, and Finnell RH (2004) Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms. Epidemiology 15:150-156. (Pubitemid 40416968)
26. Li D, Jiao L, Li Y, Doll MA, Hein DW, Bondy ML, Evans DB, Wolff RA, Lenzi R, Pisters PW, et al.(2006) Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer. Carcinogenesis 27:103-111. (Pubitemid 43025249)
27. Lilla C, Verla-Tebit E, Risch A, Jäger B, Hoffmeister M, Brenner H, and Chang-Claude J (2006) Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption. Cancer Epidemiol Biomarkers Prev 15:99-107.
28. Millikan RC, Pittman GS, Newman B, Tse CK, Selmin O, Rockhill B, Savitz D, Moorman PG, and Bell DA (1998) Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 7:371-378. (Pubitemid 28354124)
29. Millner LM, Doll MA, Cai J, States JC, and Hein DW (2011) NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl. Mol Carcinog doi:10.1002/mc.20836.
30. Morton LM, Schenk M, Hein DW, Davis S, Zahm SH, Cozen W, Cerhan JR, Hartge P, Welch R, Chanock SJ, et al. (2006) Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma. Pharmacogenet Genomics 16:537-545. (Pubitemid 44100198)
31. Nauwelaers G, Bessette EE, Gu D, Tang Y, Rageul J, Fessard V, Yuan JM, Yu MC, Langouët S, and Turesky RJ (2011) DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes. Chem Res Toxicol 24:913-925.
32. Northrop DB (1999) Rethinking fundamentals of enzyme action. Adv Enzymol Relat Areas Mol Biol 73:25-55, ix.
33. Reeves PT, Minchin RF, and Ilett KF (1988) Induction of sulfamethazine acetylation by hydrocortisone in the rabbit. Drug Metab Dispos 16:110-115. (Pubitemid 18057105)
34. Tiang JM, Butcher NJ, Cullinane C, Humbert PO, and Minchin RF (2011) RNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition. PLoS One 6:e17031.
35. Wakefield L, Cornish V, Long H, Griffiths WJ, and Sim E (2007) Deletion of a xenobiotic metabolizing gene in mice affects folate metabolism. Biochem Biophys Res Commun 364: 556-560. (Pubitemid 350030921)
36. Walraven JM, Trent JO, and Hein DW (2008) Structure-function analyses of single nucleotide polymorphisms in human N-acetyltransferase 1. Drug Metab Rev 40:169-184. (Pubitemid 351220644)
37. Weber WW and Hein DW (1985) N-acetylation pharmacogenetics. Pharmacol Rev 37:25-79. (Pubitemid 15081093)
38. Wikman H, Thiel S, Jäger B, Schmezer P, Spiegelhalder B, Edler L, Dienemann H, Kayser K, Schulz V, Drings P, et al. (2001) Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. Pharmacogenetics 11:157-168. (Pubitemid 32216126)
39. Zang Y, Doll MA, Zhao S, States JC, and Hein DW (2007) Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2. Carcinogenesis 28:1665-1671. (Pubitemid 47289027)
40. Zheng W, Deitz AC, Campbell DR, Wen WQ, Cerhan JR, Sellers TA, Folsom AR, and Hein DW (1999) N-acetyltransferase 1 genetic polymorphism, cigarette smoking, well-done meat intake, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 8:233-239. (Pubitemid 29114201)
41. Zhu Y and Hein DW (2008) Functional effects of single nucleotide polymorphisms in the coding region of human N-acetyltransferase 1. Pharmacogenomics J 8:339-348.