Rapid genotype method to distinguish frequent and/or functional polymorphisms in human N-acetyltransferase-1

Analytical Biochemistry

Volumn 301, Issue 2, 2002, Pages 328-332

  Doll, Mark A ^a   Hein, David W ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

FUNCTIONAL POLYMORPHISMS; N-ACETYLTRANSFERASES;

CHEMISTRY;

ACYLTRANSFERASE; AROMATIC AMINE; DNA; HYDRAZINE DERIVATIVE; N ACETYLTRANSFERASE 1; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ACETYLATION; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN TISSUE; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0037083681     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2001.5520     Document Type: Article

References (22)

1. N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells
2. Metabolic activation and deactivation of arylamine carcinogens by recombinant NAT1 and polymorphic NAT2 acetyltransferases
3. Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases
4. Identification of novel allele at the human NAT1 acetyltransferase locus
5. Functional polymorphism of the human arylamine N-acetyltransferase type-1 gene caused by C190T and G560A mutations
6. Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in vitro and in vivo probe
7. Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas
8. Genotyping human arylamine N-acetyltransferase type 1 (NAT1) variants
9. Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1*
10. Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1
11. Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus
12. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms
13. N-Acetyltransferase genetic polymorphism, cigarette smoking, well-done meat intake, and breast cancer risk
14. Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects
15. Association of NAT1 and NAT2 polymorphisms to urinary bladder cancer: Significantly reduced risk in subjects with NAT1*10
16. Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay
17. Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral blood
18. Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: Association of the NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue
19. Correlation between genotype and phenotype of the human arylamine N-acetyltransferase type 1
20. Relationship between NAT1 genotype and phenotype in a Japanese population
21. Pharmacogenetics of the arylamine N-acetyltransferases: A symposium in honor of Wendell W. Weber
22. Comprehensive human NAT2 genotype method using single nucleotide polymorphism-specific polymerase chain reaction primers and fluorogenic probes