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Volumn 25, Issue 6, 2011, Pages 392-401

Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α

Author keywords

Hypoxia; Iptakalim; Proliferation; Protein ki nase C (PKC ); Pulmonary arterial smooth muscle cells (PASMCs); Pulmonary hypertension

Indexed keywords

GLIBENCLAMIDE; IPTAKALIM; POTASSIUM CHANNEL; PROTEIN KINASE; PROTEIN KINASE C ALPHA;

EID: 84455172412     PISSN: 16748301     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1674-8301(11)60052-3     Document Type: Article
Times cited : (14)

References (40)
  • 1
    • 0036773104 scopus 로고    scopus 로고
    • The structural basis of pul-monary hypertension in chronic lung disease: Remodel-ling, rarefaction or angiogenesis?
    • Hopkins N, McLoughlin P The structural basis of pul-monary hypertension in chronic lung disease: Remodel-ling, rarefaction or angiogenesis?. J Anat 2002, 201:335-348.
    • (2002) J Anat , vol.201 , pp. 335-348
    • Hopkins, N.1    McLoughlin, P.2
  • 3
    • 68049105409 scopus 로고    scopus 로고
    • Pul-monary hypertension in chronic obstructive pulmonary disease and interstitial lung diseases
    • Weitzenblum E, Chaouat A, Canuet M, Kessler R Pul-monary hypertension in chronic obstructive pulmonary disease and interstitial lung diseases. Semin Respir Crit Care Med 2009, 30:458-470.
    • (2009) Semin Respir Crit Care Med , vol.30 , pp. 458-470
    • Weitzenblum, E.1    Chaouat, A.2    Canuet, M.3    Kessler, R.4
  • 4
    • 0033795729 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling: A model for what human disease?
    • Voelkel NF, Tuder RM Hypoxia-induced pulmonary vascular remodeling: A model for what human disease?. J Clin Invest 2000, 106:733-738.
    • (2000) J Clin Invest , vol.106 , pp. 733-738
    • Voelkel, N.F.1    Tuder, R.M.2
  • 5
    • 33749345684 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms
    • Stenmark KR, Fagan KA, Frid MG Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms. Circ Res 2006, 99:675-691.
    • (2006) Circ Res , vol.99 , pp. 675-691
    • Stenmark, K.R.1    Fagan, K.A.2    Frid, M.G.3
  • 6
    • 0032711658 scopus 로고    scopus 로고
    • Hypoxia stimulates proliferation and interleukin-1alpha production in human vascular smooth muscle cells
    • Cooper AL, Beasley D Hypoxia stimulates proliferation and interleukin-1alpha production in human vascular smooth muscle cells. Am J Physiol 1999, 277:H1326-H1337.
    • (1999) Am J Physiol , vol.277
    • Cooper, A.L.1    Beasley, D.2
  • 7
    • 17444387455 scopus 로고    scopus 로고
    • Inhibition of hypoxia-induced proliferation and collagen synthesis by vasonatrin peptide in cultured rat pulmo-nary artery smooth muscle cells
    • Lu SY, Wang DS, Zhu MZ, Zhang QH, Hu YZ, Pei JM Inhibition of hypoxia-induced proliferation and collagen synthesis by vasonatrin peptide in cultured rat pulmo-nary artery smooth muscle cells. Life Sci 2005, 77:28-38.
    • (2005) Life Sci , vol.77 , pp. 28-38
    • Lu, S.Y.1    Wang, D.S.2    Zhu, M.Z.3    Zhang, Q.H.4    Hu, Y.Z.5    Pei, J.M.6
  • 8
    • 33744944257 scopus 로고    scopus 로고
    • Hypoxia and hy-poxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells
    • Schultz K, Fanburg BL, Beasley D Hypoxia and hy-poxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2006, 290:H2528-H2534.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Schultz, K.1    Fanburg, B.L.2    Beasley, D.3
  • 9
    • 0025963130 scopus 로고
    • Protein kinase C activation allows pulmonary artery smooth muscle cells to proliferate to hypoxia
    • Dempsey EC, McMurtry IF, O'Brien RF Protein kinase C activation allows pulmonary artery smooth muscle cells to proliferate to hypoxia. Am J Physiol 1991, 260:L136-L145.
    • (1991) Am J Physiol , vol.260
    • Dempsey, E.C.1    McMurtry, I.F.2    O'Brien, R.F.3
  • 13
    • 39349101276 scopus 로고    scopus 로고
    • Effects of puerarin on pulmonary vascular remodeling and pro-tein kinase C-alpha in chronic cigarette smoke exposure smoke-exposed rats
    • Zhu Z, Xu Y, Zou H, Zhang Z, Ni W, Chen S Effects of puerarin on pulmonary vascular remodeling and pro-tein kinase C-alpha in chronic cigarette smoke exposure smoke-exposed rats. J Huazhong Univ Sci Technolog Med Sci 2008, 28:27-32.
    • (2008) J Huazhong Univ Sci Technolog Med Sci , vol.28 , pp. 27-32
    • Zhu, Z.1    Xu, Y.2    Zou, H.3    Zhang, Z.4    Ni, W.5    Chen, S.6
  • 14
    • 0030882437 scopus 로고    scopus 로고
    • Heterogeneity in the proliferative response of bo-vine pulmonary artery smooth muscle cells to mitogens and hypoxia: importance of protein kinase C
    • Dempsey EC, Frid MG, Aldashev AA, Das M, Stenmark KR Heterogeneity in the proliferative response of bo-vine pulmonary artery smooth muscle cells to mitogens and hypoxia: importance of protein kinase C. Can J Physiol Pharmacol 1997, 75:936-944.
    • (1997) Can J Physiol Pharmacol , vol.75 , pp. 936-944
    • Dempsey, E.C.1    Frid, M.G.2    Aldashev, A.A.3    Das, M.4    Stenmark, K.R.5
  • 15
    • 33745366991 scopus 로고    scopus 로고
    • Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties
    • Xu Y, Stenmark KR, Das M, Walchak SJ, Ruff LJ, Dempsey EC Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties. Am J Physiol 1997, 273:L234-L245.
    • (1997) Am J Physiol , vol.273
    • Xu, Y.1    Stenmark, K.R.2    Das, M.3    Walchak, S.J.4    Ruff, L.J.5    Dempsey, E.C.6
  • 16
    • 69549129206 scopus 로고    scopus 로고
    • Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension
    • Do e Z, Fukumoto Y, Takaki A, Tawara S, Ohashi J, Nakano M, et al. Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. Circ J 2009, 73:1731-1739.
    • (2009) Circ J , vol.73 , pp. 1731-1739
    • Do e, Z.1    Fukumoto, Y.2    Takaki, A.3    Tawara, S.4    Ohashi, J.5    Nakano, M.6
  • 17
    • 34347265735 scopus 로고    scopus 로고
    • Potassium channel diversity in the pulmonary arteries and pulmonary veins: Implications for regulation of the pulmonary vasculature in health and during pulmonary hypertension
    • Bonnet S, Archer SL Potassium channel diversity in the pulmonary arteries and pulmonary veins: Implications for regulation of the pulmonary vasculature in health and during pulmonary hypertension. Pharmacol Ther 2007, 115:56-69.
    • (2007) Pharmacol Ther , vol.115 , pp. 56-69
    • Bonnet, S.1    Archer, S.L.2
  • 19
    • 0036005875 scopus 로고    scopus 로고
    • ATP channels in vas-cular smooth muscle
    • ATP channels in vas-cular smooth muscle. Clin Exp Pharmacol Physiol 2002, 29:312-316.
    • (2002) Clin Exp Pharmacol Physiol , vol.29 , pp. 312-316
    • Brayden, J.E.1
  • 20
    • 0036006809 scopus 로고    scopus 로고
    • ATP channels in human pulmonary artery smooth muscle cells and their modulation by growth
    • ATP channels in human pulmonary artery smooth muscle cells and their modulation by growth. Am J Respir Cell Mol Biol 2002, 26:135-143.
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 135-143
    • Cui, Y.1    Tran, S.2    Tinker, A.3    Clapp, L.H.4
  • 21
    • 34548290425 scopus 로고    scopus 로고
    • Modulation of ion channels in pulmonary arterial hypertension
    • Guibert C, Marthan R, Savineau JP Modulation of ion channels in pulmonary arterial hypertension. Curr Pharm Des 2007, 13:2443-2455.
    • (2007) Curr Pharm Des , vol.13 , pp. 2443-2455
    • Guibert, C.1    Marthan, R.2    Savineau, J.P.3
  • 22
    • 33846013945 scopus 로고    scopus 로고
    • ATP-sensitive potassium channel openers and 2,3-dimethyl-2-butylamine derivatives
    • Wang H, Tang Y, Wang L, Long CL, Zhang YL ATP-sensitive potassium channel openers and 2,3-dimethyl-2-butylamine derivatives. Curr Med Chem 2007, 14:133-155.
    • (2007) Curr Med Chem , vol.14 , pp. 133-155
    • Wang, H.1    Tang, Y.2    Wang, L.3    Long, C.L.4    Zhang, Y.L.5
  • 23
    • 4243059647 scopus 로고    scopus 로고
    • ATP channel opener, on pulmonary vascu-lar remodeling in hypoxic rats
    • ATP channel opener, on pulmonary vascu-lar remodeling in hypoxic rats. Life Sci 2004, 75:2065-2076.
    • (2004) Life Sci , vol.75 , pp. 2065-2076
    • Xie, W.1    Wang, H.2    Hu, G.3
  • 24
    • 15744397784 scopus 로고    scopus 로고
    • ATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells
    • ATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells. Eur J Pharmacol 2005, 511:81-87.
    • (2005) Eur J Pharmacol , vol.511 , pp. 81-87
    • Xie, W.1    Wang, H.2    Ding, J.3    Hu, G.4
  • 26
    • 19944391353 scopus 로고    scopus 로고
    • Ac-tivation of PKCalpha and pulmonary vascular remodel-ling in broilers
    • Tan X, Liu YJ, Li JC, Pan JQ, Sun WD, Wang XL Ac-tivation of PKCalpha and pulmonary vascular remodel-ling in broilers. Res Vet Sci 2005, 79:131-137.
    • (2005) Res Vet Sci , vol.79 , pp. 131-137
    • Tan, X.1    Liu, Y.J.2    Li, J.C.3    Pan, J.Q.4    Sun, W.D.5    Wang, X.L.6
  • 27
    • 0032888677 scopus 로고    scopus 로고
    • Potassium channels modulate canine pul-monary vasoreactivity to protein kinase C activation
    • Barman SA Potassium channels modulate canine pul-monary vasoreactivity to protein kinase C activation. Am J Physiol 1999, 277:L558-L565.
    • (1999) Am J Physiol , vol.277
    • Barman, S.A.1
  • 28
    • 12244259694 scopus 로고    scopus 로고
    • Pathophysiology of pulmo-nary hypertension due to lung disease
    • Presberg KW, Dincer HE Pathophysiology of pulmo-nary hypertension due to lung disease. Curr Opin Pulm Med 2003, 9:131-138.
    • (2003) Curr Opin Pulm Med , vol.9 , pp. 131-138
    • Presberg, K.W.1    Dincer, H.E.2
  • 29
    • 22744457972 scopus 로고    scopus 로고
    • Vascular remodeling ver-sus vasoconstriction in chronic hypoxic pulmonary hy-pertension: A time for reappraisal?
    • Stenmark KR, McMurtry IF Vascular remodeling ver-sus vasoconstriction in chronic hypoxic pulmonary hy-pertension: A time for reappraisal?. Circ Res 2005, 97:95-98.
    • (2005) Circ Res , vol.97 , pp. 95-98
    • Stenmark, K.R.1    McMurtry, I.F.2
  • 30
    • 0034050280 scopus 로고    scopus 로고
    • Effects of angiotensin-converting en-zyme and angiotensin II on hypoxia-induced proliferation of cultured intra-pulmonary artery smooth muscle cells
    • Yu TZ, Ma CT Effects of angiotensin-converting en-zyme and angiotensin II on hypoxia-induced proliferation of cultured intra-pulmonary artery smooth muscle cells. Acta Pharmacol Sin 2000, 21:381-384.
    • (2000) Acta Pharmacol Sin , vol.21 , pp. 381-384
    • Yu, T.Z.1    Ma, C.T.2
  • 31
    • 0036855463 scopus 로고    scopus 로고
    • Protein kinase C alpha (PKCalpha): Regu-lation and biological function
    • Nakashima S Protein kinase C alpha (PKCalpha): Regu-lation and biological function. J Biochem 2002, 132:669-675.
    • (2002) J Biochem , vol.132 , pp. 669-675
    • Nakashima, S.1
  • 32
    • 0034809792 scopus 로고    scopus 로고
    • Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration
    • Itoh H, Yamamura S, Ware JA, Zhuang S, Mii S, Liu B, et al. Differential effects of protein kinase C on human vascular smooth muscle cell proliferation and migration. Am J Physiol Heart Circ Physiol 2001, 281:H359-H370.
    • (2001) Am J Physiol Heart Circ Physiol , vol.281
    • Itoh, H.1    Yamamura, S.2    Ware, J.A.3    Zhuang, S.4    Mii, S.5    Liu, B.6
  • 33
    • 20044364571 scopus 로고    scopus 로고
    • ATP-sensitive potassium channels
    • Rodrigo GC, Standen NB ATP-sensitive potassium channels. Curr Pharm Des 2005, 11:1915-1940.
    • (2005) Curr Pharm Des , vol.11 , pp. 1915-1940
    • Rodrigo, G.C.1    Standen, N.B.2
  • 34
    • 33645824084 scopus 로고    scopus 로고
    • + channels in smooth muscle
    • + channels in smooth muscle. J Physiol 2006, 572:617-624.
    • (2006) J Physiol , vol.572 , pp. 617-624
    • Teramoto, N.1
  • 36
    • 0026554833 scopus 로고
    • + channels regulate resting potential of pulmonary arterial smooth muscle cells
    • + channels regulate resting potential of pulmonary arterial smooth muscle cells. Am J Physiol 1992, 262:H916-H920.
    • (1992) Am J Physiol , vol.262
    • Clapp, L.H.1    Gurney, A.M.2
  • 37
    • 0027527064 scopus 로고
    • Nip-121 is more ef-fective than nifedipine in acutely reversing chronic pul-monary hypertension
    • Oka M, Morris KG, McMurtry IF Nip-121 is more ef-fective than nifedipine in acutely reversing chronic pul-monary hypertension. J Appl Physiol 1993, 75:1075-1080.
    • (1993) J Appl Physiol , vol.75 , pp. 1075-1080
    • Oka, M.1    Morris, K.G.2    McMurtry, I.F.3
  • 38
    • 1242337465 scopus 로고    scopus 로고
    • ATP channel openers: Structure-activity relationships and therapeutic potential
    • ATP channel openers: Structure-activity relationships and therapeutic potential. Med Res Rev 2004, 24:213-266.
    • (2004) Med Res Rev , vol.24 , pp. 213-266
    • Mannhold, R.1
  • 39
    • 33846116157 scopus 로고    scopus 로고
    • A new ATP-sensitive potassium channel opener protects endothelial function in cultured aortic endothelial cells
    • Wang H, Long C, Duan Z, Shi C, Jia G, Zhang Y A new ATP-sensitive potassium channel opener protects endothelial function in cultured aortic endothelial cells. Cardiovasc Res 2007, 73:497-503.
    • (2007) Cardiovasc Res , vol.73 , pp. 497-503
    • Wang, H.1    Long, C.2    Duan, Z.3    Shi, C.4    Jia, G.5    Zhang, Y.6
  • 40
    • 59849087929 scopus 로고    scopus 로고
    • Activation of ATP-sensitive potassium chan-nels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia
    • Long CL, Qin XC, Pan ZY, Chen K, Zhang YF, Cui WY, et al. Activation of ATP-sensitive potassium chan-nels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia. J Hy-pertens 2008, 26:2326-2338.
    • (2008) J Hy-pertens , vol.26 , pp. 2326-2338
    • Long, C.L.1    Qin, X.C.2    Pan, Z.Y.3    Chen, K.4    Zhang, Y.F.5    Cui, W.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.