Altered intestinal epithelium-associated lymphocyte repertoires and function in Apc Min/+ mice

International Journal of Oncology

Volumn 40, Issue 1, 2012, Pages 243-250

  Marsh, Loraine ^a   Coleta, P Louise ^b   Hul, Mark A ^b   Selby, Peter J ^c   Carding, Simon R ^a,d  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Adenoma; Intraepithelial lymphocytes IEL cytotoxicity; Min mouse; Tumorigenesis

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8ALPHA ANTIGEN; FAS ANTIGEN; FAS LIGAND; GRANZYME; PERFORIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN;

ADENOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL KILLING; CYTOTOXICITY; FEMALE; IMMUNOREGULATION; INTESTINE CANCER; INTESTINE EPITHELIUM; LYMPHOCYTE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TARGET CELL; WILD TYPE;

ADENOMA; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; INTESTINE, SMALL; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS;

EID: 84455163036     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1176     Document Type: Article

References (53)

1. Moser AR, Pitot HC and Dove WF: A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247: 322-324, 1990.
2. Su LK, Kinzler KW, Vogelstein B, et al.: Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256: 668-670, 1992.
3. Gregorieff A and Clevers H: Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 19: 877-890, 2005.
4. Nusse R: Wnt signaling in disease and in development. Cell Res 15: 28-32, 2005.
5. Paulsen JE, Steffensen IL, Namork E, Eide TJ and Alexander J: Age-dependent susceptibility to azoxymethane-induced and spontaneous tumorigenesis in the Min/+ mouse. Anticancer Res 23: 259-265, 2003.
6. Shoemaker AR, Moser AR, Midgley CA, Clipson L, Newton MA and Dove WF: A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in Apc(Min/+) mice. Proc Natl Acad Sci USA 95: 10826-10831, 1998.
7. Moser AR, Dove WF, Roth KA and Gordon JI: The Min (multiple intestinal neoplasia) mutation-its effect on gut epithelial-cell differentiation and interaction with a modifier system. J Cell Biol 116: 1517-1526, 1992.
8. Dietrich WF, Lander ES, Smith JS, et al.: Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 75: 631-639, 1993.
9. Silverman KA, Koratkar R, Siracusa LD and Buchberg AM: Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Genome Res 12: 88-97, 2002.
10. Suraweera N, Robinson J, Volikos E, et al.: Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. Int J Cancer 119: 1837-1842, 2006.
11. Kwong LN, Shedlovsky A, Biehl BS, Clipson L, Pasch CA and Dove WF: Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18. Genetics 176: 1237-1244, 2007.
12. Wilding J, Straub J, Bee J, et al.: Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice. Cancer Res 62: 4562-4565, 2002.
13. Dove WF, Clipson L, Gould KA, et al.: Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status. Cancer Res 57: 812-814, 1997.
14. Dudley ME, Sundberg JP and Roopenian DC: Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation. Int J Cancer 65: 249-253, 1996.
15. Bouhnik Y, Vahedi K, Achour L, et al.: Short-chain fructooligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 129: 113-116, 1999.
16. Howard MD, Gordon DT, Garleb KA and Kerley MS: Dietary fructooligosaccharide, xylooligosaccharide and gum arabic have variable effects on cecal and colonic microbiota and epithelial cell proliferation in mice and rats. J Nutr 125: 2604-2609, 1995.
17. Pierre F, Perrin P, Champ M, Bornet F, Meflah K and Menanteau J: Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. Cancer Res 57: 225-228, 1997.
18. Pierre F, Perrin P, Bassonga E, Bornet F, Meflah K and Menanteau J: T cell status influences colon tumor occurrence in min mice fed short chain fructo-oligosaccharides as a diet supplement. Carcinogenesis 20: 1953-1956, 1999.
19. + T cells are the main targets. Cancer Immunol Immunother 54: 78-86, 2005.
20. Erdman SE and Poutahidis T: Roles for inflammation and regulatory T cells in colon cancer. Toxicol Pathol 38: 76-87, 2010.
21. Min/+ mice. Cancer Res 65: 3998-4004, 2005.
22. Cheroutre H and Kronenberg M: Mucosal T lymphocytespeacekeepers and warriors. Springer Semin Immunopathol 27: 147-165, 2005.
23. van Wijk F and Cheroutre H: Intestinal T cells: facing the mucosal immune dilemma with synergy and diversity. Semin Immunol 21: 130-138, 2009.
24. + intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation. J Exp Med 173: 483-486, 1991.
25. Suzuki H, Jeong KI, Okutani T and Doi K: Regional variations in the distribution of small intestinal intraepithelial lymphocytes in three inbred strains of mice. J Vet Med Sci 62: 881-887, 2000.
26. Hayday A, Theodoridis E, Ramsburg E and Shires J: Intraepithelial lymphocytes: exploring the Third Way in immunology. Nat Immunol 2: 997-1003, 2001.
27. Groh V, Steinle A, Bauer S and Spies T: Recognition of stressinduced MHC molecules by intestinal epithelial gammadelta T cells. Science 279: 1737-1740, 1998.
28. Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH and Spies T: Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci USA 96: 6879-6884, 1999.
29. Van Kaer L, Wu M, Ichikawa Y, et al.: Recognition of MHC TL gene products by gamma delta T cells. Immunol Rev 120: 89-115, 1991.
30. Cerwenka A and Lanier LL: NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. Tissue Antigens 61: 335-343, 2003.
31. Ke Y, Kapp LM and Kapp JA: Inhibition of tumor rejection by gammadelta T cells and IL-10. Cell Immunol 221: 107-114, 2003.
32. Seo N, Tokura Y, Takigawa M and Egawa K: Depletion of IL-10- and TGF-beta-producing regulatory gamma delta T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells. J Immunol 163: 242-249, 1999.
33. Min/+ mouse, a model for colon cancer. Cancer Res 63: 5136-5142, 2003.
34. Scott DJ, Hull MA, Cartwright EJ, et al.: Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. Gastroenterology 121: 889-899, 2001.
35. Corazza N, Muller S, Brunner T, Kagi D and Mueller C: Differential contribution of Fas- and perforin-mediated mechanisms to the cell-mediated cytotoxic activity of naive and in vivo-primed intestinal intraepithelial lymphocytes. J Immunol 164: 398-403, 2000.
36. Guy-Grand D, Griscelli C and Vassalli P: The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions. J Exp Med 148: 1661-1677, 1978.
37. Haigis KM, Hoff PD, White A, Shoemaker AR, Halberg RB and Dove WF: Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proc Natl Acad Sci USA 101: 9769-9773, 2004.
38. Min/+ mice. J Appl Physiol 98: 2219-2225, 2005.
39. You S, Ohmori M, Pena MM, et al.: Developmental abnormalities in multiple proliferative tissues of Apc(Min/+) mice. Int J Exp Pathol 87: 227-236, 2006.
40. Cheroutre H: IELs: enforcing law and order in the court of the intestinal epithelium. Immunol Rev 206: 114-131, 2005.
41. Min/+ mouse model of intestinal tumorigenesis. Blood 103: 1050-1058, 2004.
42. Cheroutre H and Lambolez F: Doubting the TCR coreceptor function of CD8alpha alpha. Immunity 28: 149-159, 2008.
43. Verbeek S, Izon D, Hofhuis F, et al.: An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 374: 70-74, 1995.
44. Reya T, O'Riordan M, Okamura R, et al.: Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 13: 15-24, 2000.
45. Kirstetter P, Anderson K, Porse BT, Jacobsen SE and Nerlov C: Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 7: 1048-1056, 2006.
46. Pang YL, Zhang HG, Peng JR, et al.: The immunosuppressive tumor microenvironment in hepatocellular carcinoma. Cancer Immunol Immunother 58: 877-886, 2009.
47. + intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice. J Immunol 156: 2710-2715, 1996.
48. Kaufmann SH, Blum C and Yamamoto S: Crosstalk between alpha/beta T cells and gamma/delta T cells in vivo: activation of alpha/beta T-cell responses after gamma/delta T-cell modulation with the monoclonal antibody GL3. Proc Natl Acad Sci USA 90: 9620-9624, 1993.
49. Bandeira A, Mota-Santos T, Itohara S, et al.: Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization. J Exp Med 172: 239-244, 1990.
50. Guy-Grand D, Pardigon N, Darche S, Lantz O, Kourilsky P and Vassalli P: Contribution of double-negative thymic precursors to CD8alpha alpha (+) intraepithelial lymphocytes of the gut in mice bearing TCR transgenes. Eur J Immunol 31: 2593-2602, 2001.
51. Chen Y, Chou K, Fuchs E, Havran WL and Boismenu R: Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci USA 99: 14338-14343, 2002.
52. Komano H, Fujiura Y, Kawaguchi M, et al.: Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells. Proc Natl Acad Sci USA 92: 6147-6151, 1995.
53. Yang H, Antony PA, Wildhaber BE and Teitelbaum DH: Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse. J Immunol 172: 4151-4158, 2004.