Contribution of double-negative thymic precursors to CD8αα+ intraepithelial lymphocytes of the gut in mice bearing TCR transgenes

European Journal of Immunology

Volumn 31, Issue 9, 2001, Pages 2593-2602

  Guy Grand, Delphine ^a,c   Pardigon, Nathalie ^a   Darche, Sylvie ^b   Lantz, Olivier ^a   Kourilsky, Philippe ^b   Vassalli, Pierre ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Double negative thymocyte; Gut intraepithelial lymphocyte; Thymus independent lymphocyte; Transgenic anti HY mice

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL TISSUE; ARTICLE; CELL MATURATION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HEMATOPOIETIC STEM CELL; INTESTINE EPITHELIUM; INTESTINE MUCOSA; INTESTINE WALL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; LYMPHOID ORGAN; MALE; MOUSE; MUTANT; NONHUMAN; NUDE MOUSE; ONTOGENY; PHENOTYPE; PRIORITY JOURNAL; PROLYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE; THYMOCYTE; THYMUS; TRANSGENE;

ANIMALS; ANTIGENS, CD3; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL MOVEMENT; DNA-BINDING PROTEINS; FEMALE; H-Y ANTIGEN; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOPHENOTYPING; INTESTINAL MUCOSA; MALE; MICE; MICE, KNOCKOUT; MICE, NUDE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STEM CELLS; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TRANSGENES;

EID: 0034801716     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200109)31:9<2593::AID-IMMU2593>3.0.CO;2-X     Document Type: Article

References (44)

1. Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: A role for the gut epithelium in T cell differentiation
2. Extrathymic origin of intestinal intraepithelial lymphocytes bearing T cell antigen receptor γδ
3. Identical T cell clones are located within the mouse gut epithelium and lamina propria and circulate in the thoracic duct lymph
4. Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation
5. Differential contribution of the FcRγ chain to the surface expression of the T cell receptor among T cells localized in epithelia: Analysis of FcRγ-deficient mice
6. Complexity of the mouse gut T cell immune system: Identification of two distinct natural killer-T cell intraepithelial lineages
7. The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta+ lymphocytes reveals a major extrathymic pathway of T cell differentiation
8. TCRαβ+ CD8αα+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules
9. Development of CD8αα and CD8αβ T cells in major histocompatibility complex class I-deficient mice
10. + intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and non classical CD1 molecules
11. Different expression of the recombination activity gene RAG-1 in various populations of thymocytes, peripheral T cells and gut thymus-independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement
12. CD3-CD8+ intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL
13. Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop
14. Generation of intestinal T cells from progenitors residing in gut cryptopatches
15. Gut cryptopatches: Direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis
16. Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice
17. Reconstitution of the extrathymic intestinal T cell compartment in the absence of irradiation
18. Progenies of fetal thymocytes are the major source of CD4-CD8+ αα intraepithelial lymphocytes early in ontogeny
19. A novel pathway of thymus-directed T lymphocyte maturation
20. Developmental biology of T cells in T cell-receptor transgenic mice
21. Selection of intra-epithelial lymphocytes with CD8αα coreceptors by self-antigen in the murine gut
22. An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intra-epithelial lymphocytes
23. Exclusion and inclusion of α and β T cell receptor alleles
24. Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+CD8+) thymocytes in normal and genetically modified mice
25. Premature expression of T cell recptor (TCR) αβ supresses TCRγδ gene rearrangements but permits development of γδ lineage T cells
26. Small bowel enteropathy: Role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-γ, TNF) in the induction of epithelial cell death and renewal
27. An unusual lineage of αβT cells that contains autoreactive cells
28. Early T lymphocytes progenitors
29. T cell receptor (TCR)-β gene recombination: Dissociation from cell cycle regulation and developmental progression during T cell ontogeny
30. Pleiotropic changes controlled by the pre-T cell receptor
31. To be or not to be a pro-T?
32. Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis
33. Common γchain-dependent cytokines: Essential for naive CD4+ T cell survival but not for antigen-induced proliferation or memory responses in vivo
34. The αβ T cell receptor can replace the γδ receptor in the development of γδ lineage
35. The αβ versus γδ T cell lineage choice
36. Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on γδ T cell receptor-positive intraepithelial lymphocytes
37. The pleiotropic functions of interleukin 15: Not so interleukin 2-like after all
38. Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells
39. Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease
40. Analysis of the intraepithelial lymphocyte compartment in SCID mice that received co-isogenic CD4+ T cells. Evidence that mature post-thymic CD4+ T cells can be induced to express CD8α in vivo
41. The role of β7 integrins in CD8 T cell trafficking during an antiviral immune response
42. Induction of germline transcription in the TCRγ locus by stat5: Implications for accessibility control by the IL-7 receptor
43. Defective development of γ/β T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor γ genes
44. Enterocyte expression of interleukin 7 induces development of γδ T cells and Peyer's patches