Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia

Genome Research

Volumn 12, Issue 1, 2002, Pages 88-97

  Silverman, Karen A ^a   Koratkar, Revati ^a   Siracusa, Linda D ^a   Buchberg, Arthur M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE;

ADENOMATOSIS; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 18; CHROMOSOME 4; COLON POLYPOSIS; CONTROLLED STUDY; FEMALE; GENE IDENTIFICATION; GENE LOCUS; GENE MUTATION; GENE REPRESSION; GENETIC CODE; GENETIC RESISTANCE; GENETIC VARIABILITY; INTESTINE; INTESTINE POLYP; INTESTINE TUMOR; LINKAGE ANALYSIS; MALE; MOLECULAR GENETICS; MOUSE; MULTIPLE CANCER; NONHUMAN; PANCREAS SECRETION; PRIORITY JOURNAL; PROTEIN MODIFICATION; TUMOR VOLUME;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; BREEDING; CHROMOSOME MAPPING; COLON; FEMALE; GENES, APC; GENETIC MARKERS; GERM-LINE MUTATION; INTESTINAL NEOPLASMS; INTESTINE, SMALL; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MUTATION; POLYPS; QUANTITATIVE TRAIT, HERITABLE;

ANIMALIA;

EID: 0036141923     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.206002     Document Type: Article

References (55)

1. Cancer resistance genes in mice: Models for the study of tumour modifiers
2. Mouse models of human disease. Part II: Recent progress and future directions
3. Molecular diagnostics of cancer predisposition: Hereditary non-polyposis colorectal carcinoma and mismatch repair defects
4. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
5. The Genetics of Cancer Susceptibility
6. Genome maps IV 1993 Wall chart
7. The Mom1 AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64
8. Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis
9. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse
10. A comprehensive genetic map of the mouse genome
11. A genetic map of the mouse with 4,006 simple sequence length polymorphisms
12. Emergent issues in the genetics of intestinal neoplasia
13. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
14. Biology of the adenomatous polyposis coli tumor suppressor
15. Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice
16. Localized gene action controlling intestinal neoplasia in mice
17. Cancer statistics, 2000
18. Identification and characterization of the familial adenomatous polyposis coli gene
19. Mouse models for colorectal cancer
20. A gene for familial juvenile polyposis maps to chromosome 18q21.1
21. Mouse ENU mutagenesis
22. A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains
23. Identification of FAP locus genes from chromosome 5q21
24. Studying cancer in the mouse
25. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
26. Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: Identification of seven novel somatic mutations in tumors from Japanese patients
27. Familial adenomatous polyposis
28. The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia
29. Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer
30. Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
31. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors
32. Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
33. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
34. The Min (multiple intestinal neoplasia) mutation: Its effect on gut epithelial cell differentiation and interaction with a modifier system
35. ApcMin: A mouse model for intestinal and mammary tumorigenesis
36. ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias
37. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
38. Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation
39. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
40. Mutation of a mutL. homolog in hereditary colon cancer
41. APC mutations occur early during colorectal tumorigenesis
42. Chromosome 18
43. Functional genomics in the mouse: Phenotype-based mutagenesis screens
44. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
45. Allelic variation within the Emv-15 locus defines genomic sequences closely linked to the agouti locus on mouse chromosome 2
46. Apc1638N: A mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts
47. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
48. Somatic alterations of the DPC4 gene in human colorectal cancers in vivo
49. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
50. Apc gene knockout mice as a model for familial adenomatous polyposis
51. DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination
52. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
53. The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model
54. Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice