The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells

Journal of Immunology

Volumn 173, Issue 10, 2004, Pages 6220-6227

  Parikh, Neha ^a   Sade, Hadassah ^a   Kurian, Leo ^a   Sarin, Apurva ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REAGENT; UO 126;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DELETION MUTANT; ENZYME INHIBITION; ENZYME REGULATION; ENZYME REPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STIMULATION; T LYMPHOCYTE;

EID: 8444231180     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.10.6220     Document Type: Article

References (36)

1. Ashkenazi, A., and V. M. Dixit. 1998. Death receptors: signaling and modulation. Science 281:1305.
2. Wallach, D., E. E. Varfolomeev, N. L. Malinin, Y. V. Goltsev, A. V. Kovalenko, and M. P. Boldin. 1999. Tumor necrosis factor receptor and Fas signaling mechanisms. AOTH. Rev. Immunol. 17:331.
3. Desagher, S., and J. C. Martinou. 2000. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10:369.
4. Zamzami, N., and G. Kroemer. 2001. The mitochondrion in apoptosis: how Pandora's box opens. Nat. Rev. Mol. Cell Biol. 2:67.
5. Vander Heiden, M. G., and C. B. 1999. Thompson. Bcl-2 proteins: regulators of apoptosis or mitochondrial homeostasis? Nat. Cell. Biol. 1:E209.
6. Rathmell, J. C., T. Lindsten, Z. Wei-Xing, R. M. Cinalli, and C. T. Thompson. 2002. Deficiency in bak and bax perturbs thymic selection and lymphoid homeostasis. Nat. Immunol. 3:932.
7. Brady, H. J. M., G. S. Salomons, R. C. Bobeldijk, and A. J. M. Berns. 1996. T cells from bax transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53. EMBO J. 15:1221.
8. Lin, J. X., T. S. Migone, M. Tsang, M. Friedmann, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, et al. 1995. The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity 2:331.
9. Lodolce, J. P., D. L. Boone, S. Chai, R. E. Swain, T. Dassopoulos, S. Trettin, and A. Ma. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669.
10. Maraskovsky, E., M. Teepe, P. J. Morrissey, S. Braddy, R. E. Miller, D. H. Lynch, and J. J. Peschon. 1996. Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells. J. Immunol. 157:5315.
11. Perkins, G. R., J. Marvel, and M. K. Collins. 1993. Interleukin 2 activates extracellular signal-regulated protein kinase 2. J. Exp. Med. 178:1429.
12. Moon, J. J., and B. H. Nelson. 2001. Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor. J. Immunol. 167:2714.
13. Gu, H., H. Maeda, J. J. Moon, J. D. Lord, M. Yoakim, B. H. Nelson, and B. G. Neel. 2000. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol. Cell. Biol. 20:7109.
14. L, and Mcl-1 and promotes survival of human pancreatic cancer cells. J. Cell. Biochem. 79:355.
15. Pardo, O. E., A. Arcaro, O. Salerno, S. Raguz, J. Downward, and M. J. Seckl. 2002. Fibroblast growth factor-2 induces translational regulation of Bcl-xL and Bcl-2 via a MEK-dependent pathway. J. Biol. Chem. 277:12040.
16. Scheid, M. P., and V. Duronio. 1998. Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/Akt: involvement of MEK upstream of Bad phosphorylation. Proc. Natnl. Acad. Sci. USA 95:7439.
17. Varghese, J., H. Sade, P. Vandenabeele, and A. Sarin. 2002. Head involution (Hid) triggered apoptosis requires caspase-8 but not FADD (Fas associated death domain) and is regulated by the extracellular signal-related kianse-I/2 (Erk) in mammalian cells. J. Biol. Chem. 277:35097.
18. Tashker, J. S., M. Olsen, and S. Kornbluth. 2002. Post-cytochrome c protection from apoptosis conferred by a MAPK pathway in Xenopus egg extracts. Mol. Cell. Biol. 13:393.
19. Erhardt, P., E. I. Schremser, and G. M. Cooper. 1999. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol. Cell. Biol. 19:5308.
20. Datta, S. R., A. Brunet, and M. E. Greenberg. 1999. Cellular survival: a play in three Akts. Genes Dev. 13:2905.
21. Zhang, X. D., J. M. Borrow, X. Y. Zhang, T. Nguyen, and P. Hersey. 2003. Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria. Oncogene 22:2869.
22. Tsuruta, F., N. Masuyama, and Y. Gotoh. 2002. The Phosphatidylinositol 3-Kinase (PI3K)-Akt Pathway Suppresses Bax Translocation to Mitochondria. J. Biol. Chem. 277:14040.
23. Gardai, S. J., D. A. Hildeman, S. K. Frankel, B. B. Whitlock, S. C. Frasch, N. Borregaard, P. Marrack, D. L. Bratton, and P. M. Henson. 2004. Phosphorylation of Bax serine 184 by Akt regulates its activity and apoptosis in neutrophils. J. Biol. Chem. 279:21085.
24. Nomura, M., S. Shimizu, T. Sugiyama, M. Narita, T. Ito, H. Matsuda, and Y. Tsujimoto. 2003. 14-3-3 interacts directly with and negatively regulates proapoptotic Bax. J. Biol. Chem. 278:2058.
25. Sawada, M., W. Sun, P. Hayes, K. Leskov, D. A. Boothman, and S. Matsuyama. 2003. Ku70 suppresses the apoptotic translocation of Bax to mitochondria. Nat. Cell. Biol. 5:320.
26. Wolter, K. G., Y. T. Hsu, C. L. Smith, A. Nechustan, X. G. Xi, and R. J. Youle. 1997. Movement of Bax from the cytosol to mitochondria during apoptotsis. J. Cell Biol. 139:1281.
27. Nechustan, A., C. L. Smith, Y. T. Hsu, and R. J. Youle. 1999. Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J. 18:2330.
28. Coping, I. S., A. Gross, J. N. Lavoie, M. Nguyen, R. Jemmerson, K. Roth, S. J. Korsemeyer, and G. C. Shore. 1998. Regulated targeting of BAX to mitochondria. J. Cell Biol. 143:207.
29. Sade, H., and A. Sarin. 2003. IL-7 inhibits dexamethasone-induced apoptosis via Akt/PKB in mature, peripheral T cells. Eur. J. Immunol. 33:913.
30. Cartron, P. F., M. Priault, L. Oliver, K. Meflah, S. Manon, and F. M. Vallette. 2003. The N-terminal end of Bax contains a mitochondrial-targeting signal. J. Biol. Chem. 278:11633.
31. Puthalakath, H., and A. Strasser. 2002. Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ. 9:505.
32. Schluns, K. S., and L. Lefrancois. 2003. Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 3:269.
33. S. M. Kaech, S. Hemby, E. Kerch, and R. Ahmed. 2002. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111:837.
34. Song, I., S. Salek-Ardakani, P. R. Rogers, M. Cheng, L. Van Parijs, and M. Croft. 2004. The costimulation-regulated duration of PKB activation controls T cell longevity. Nat. Immunol. 5:150.
35. Wood, D. E., and E. W. Newcomb. 2000. Cleavage of Bax enhances its cell death function. Exp. Cell Res. 256:375.
36. Cartron, P. F., L. Oliver, P. Juin, K. Meflah, and F. M. Vallette. 2004. The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein. J. Biol. Chem. 279:11503.