Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis

Journal of Dermatological Science

Volumn 36, Issue 3, 2004, Pages 157-164

  Ito, Mikito ^a   Ogawa, Kaoru ^a   Takeuchi, Kaori ^a   Nakada, Akiko ^a   Heishi, Masayuki ^a   Suto, Hajime ^b   Mitsuishi, Kouichi ^b   Sugita, Yuji ^a,d   Ogawa, Hideoki ^b   Ra, Chisei ^b,c  

^a Genox Research Inc   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIHON UNIVERSITY   (Japan)

^d ASTELLAS PHARMA INC   (Japan)

Author keywords

Atopic dermatitis; Psoriasis; Tryptophan degradation pathway

Indexed keywords

GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINASE; MESSENGER RNA; TRYPTOPHAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA MICROARRAY; ENZYME DEGRADATION; EPIDERMIS; EXTERNAL EAR; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PATIENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; QUANTITATIVE ANALYSIS; SKIN BIOPSY; SKIN DEFECT; UPREGULATION;

ADULT; ANIMALS; CELLS, CULTURED; DERMATITIS, ATOPIC; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROLASES; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERFERON TYPE II; INTERLEUKIN-13; INTERLEUKIN-4; KERATINOCYTES; MALE; MICE; MICE, INBRED STRAINS; MIDDLE AGED; PSORIASIS; RNA, MESSENGER; TRYPTOPHAN; TRYPTOPHAN OXYGENASE; UP-REGULATION;

EID: 8444230587     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2004.08.012     Document Type: Article

References (24)

1. C.A. Akdis, M. Akdis, A. Trautmann, and K. Blaser Immune regulation in atopic dermatitis Curr Opin Immunol 12 2000 641 646
2. B.J. Nickoloff The immunologic and genetic basis of psoriasis Arch Dermatol 135 1999 1104 1110
3. T.W. Stone, and L.G. Darlington Endogenous kynurenines as targets for drug discovery and development Nature Rev 1 2002 609 620
4. W. Daubener, and C.R. MacKenzie IFN-γ activated indoleamine 2,3-dioxygenase activity in human cells is an antiparasitic and an antibacterial effector mechanism Adv Exp Med Biol 467 1999 517 524
5. B. Widner, G. Weiss, and D. Fuchs Tryptophan degradation to control T-cell responsiveness Immunol Today 21 2000 250
6. O. Takikawa, T. Kuroiwa, F. Yamazaki, and R. Kido Mechanism of interferon-γ action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-γ and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity J Biol Chem 263 1988 2041 2048
7. J. Hanifin, and G. Rajka Diagnostic features of atopic dermaitis Acta Dermatol Venereol Suppl 92 1980 44 47
8. T. Sasakawa, Y. Higashi, S. Sakuma, Y. Hirayama, Y. Sasakawa, and Y. Ohkubo Atopic dermatitis-like skin lesions induced by topical application of mite antigens in NC/Nga mice Int Arch Allergy Immnunol 126 2001 239 247
9. M. Heishi, Y. Imai, H. Katayama, R. Hashida, M. Ito, and A. Shinagawa Gene expression analysis of atopic dermatitis-like skin lesions induced in NC/Nga mice by mite antigen stimulation under specific pathogen-free conditions Int Arch Allergy Immunol 132 2003 355 363
10. M. Heishi, S. Kagaya, T. Katsunuma, T. Nakajima, K. Yuki, and A. Akasawa High-density oligonucleotide array analysis of mRNA transcripts in peripheral blood cells of severe atopic dermatitis patients Int Arch Allergy Immunol 129 2002 57 66
11. I. Nomura, B. Gao, M. Boguniewicz, M.A. Darst, J.B. Travers, and D.Y.M. Leung Distinctive patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis J Allergy Clin Immunol 112 2003 1195 1202
12. M. Akaiwa, B. Yu, R. Umeshita-Suyama, N. Terada, H. Suto, and T. Koga Localization of human interleukin 13 receptor in non-haematopoietic cells Cytokine 13 2001 75 84
13. J. Wongpiyabovorn, H. Suto, H. Ushino, K. Izuhara, K. Mitsuishi, and S. Ikeda Up-regulation of interleukin-13 receptor α1 on human keratinocytes in the skin of psoriasis and atopic dermatitis J Dermatol Sci 33 2003 31 40
14. E.R. Pfefferkorn, S. Rebhun, and M. Eckel Characterization of an indoleamine 2,3-dioxygenase induced by γ-interferon in cultured human fibroblasts J Interferon Res 6 1986 267 279
15. W. Yuan, A. Collado-Hidalgo, T. Yufit, M. Taylor, and J. Varga Modulation of cellular tryptophan metabolism in human fibroblasts by transforming growth factor-β: selective inhibition of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase gene expression J Cell Physiol 177 1998 174 186
16. D. von Bubnoff, H. Matz, C. Frahnert, M.L. Rao, D. Hanau, and H. de la Salle Fc ε RI induces the tryptophan degradation pathway involved in regulating T cell responses J Immunol 169 2002 1810 1886
17. C.R. MacKenzie, U. Hadding, and W. Daubener Interferon γ-induced activation of indoleamine 2,3-dioxygenase in cord blood monocyte-derived macrophages inhibits the growth of group B streptococci J Infect Dis 178 1998 875 878
18. R.L. Gallo, M. Murakami, T. Ohtake, and M. Zaiou Biology and clinical relevance of naturally occurring antimicrobial peptides J Allergy Clin Immunol 110 2002 823 831
19. D.H. Munn, E. Shafizadeh, J.T. Attwood, I. Bondarev, A. Pashine, and A.L. Mellor Inhibition of T cell proliferation by macrophage tryptophan catabolism J Exp Med 189 1999 1363 1372
20. P. Hwu, M.X. Du, R. Lapointe, M. Do, M.W. Taylor, and H.A. Young Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation J Immunol 164 2000 3596 3599
21. P. Terness, T.M. Bauer, L. Rose, C. Dufter, A. Watzlik, and H. Simon Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites J Exp Med 196 2002 447 457
22. G. Frumento, R. Rotondo, M. Tonetti, G. Damonte, U. Benatti, and G.B. Ferrara Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase J Exp Med 196 2002 459 468
23. A.L. Mellor, J. Sivakumar, P. Chandler, K. Smith, H. Molina, and D. Mao Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy Nature Immunol 2 2001 64 68
24. T.W. Stone Endogenous neurotoxins from tryptophan Toxicon 39 2001 61 73