Tryptophan degradation to control T-cell responsiveness [2]

Immunology Today

Volumn 21, Issue 5, 2000, Pages 250-

  Widner, B ^a   Weiss, G ^a   Fuchs, D ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; ESSENTIAL AMINO ACID; GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; NEOPTERIN; QUINOLINIC ACID; TRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA;

ANTIGENICITY; AUTOIMMUNE DISEASE; CONTROLLED STUDY; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNOREACTIVITY; LETTER; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MALIGNANT NEOPLASTIC DISEASE; MONOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE ACTIVATION;

EID: 0034069422     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01616-9     Document Type: Letter

References (9)

1. A.L. Mellor D.H. Munn Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol. Today 20 1999 469 473
2. D.H. Munn Prevention of allogeneic fetal rejection by tryptophan catabolism Science 281 1998 1191 1193
3. G. Byrne Induction of tryptophan degradation in vitro and in vivo : a gamma-interferon-stimulated activity J. Interferon Res. 6 1986 389 396
4. E.R. Werner Human macrophages degrade tryptophan upon induction by interferon-gamma Life Sci. 41 1987 273 –280
5. D. Fuchs Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum J. Acquired Immune Defic. Syndr. 3 1990 873 876
6. H. Denz Weight loss in patients with hematological neoplasias is associated with immune system stimulation Clin. Invest. 71 1993 37 41
7. B. Widner Degradation of tryptophan in patients with systemic lupus erythematosus Adv. Exp. Med. Biol. 467 1999 571 577
8. T. Gasse G.A. Qureshi H. Parvez P. Caudy S. Parvesz Progress in HPLC–HPCE: Neurochemical Markers of Degenerative Nervous Diseases and Drug Addiction (Vol. 7) 1998 VSP 351 382
9. D. Fuchs Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation Immunol. Lett. 23 1989 103 108