Hypothyroidism and cognition in the elderly;Hypothyroïdie et cognition chez le sujet âgé

Geriatrie et Psychologie Neuropsychiatrie du Vieillissement

Volumn 9, Issue 4, 2011, Pages 477-489

  Chavanne, Dominique ^a   Constans, Thierry ^a   Petit, Anne ^a   Mondon, Karl ^a,b   Hommet, Caroline ^a,b  

^a UNIVERSITY HOSPITAL OF TOURS   (France)

^b UNIVERSITÉ DE TOURS   (France)

Author keywords

Dementia; Elderly; Executive functions; Hypothyroidism; Memory

Indexed keywords

THYROID HORMONE;

ADULT; AGE; AGED; ANIMAL; BLOOD; BRAIN; COMPLICATION; CROSS-SECTIONAL STUDY; DEMENTIA; FEMALE; HUMAN; HYPOTHYROIDISM; LONGITUDINAL STUDY; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; PATHOPHYSIOLOGY; VERY ELDERLY; YOUNG ADULT;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANIMALS; BRAIN; CROSS-SECTIONAL STUDIES; DEMENTIA; FEMALE; HUMANS; HYPOTHYROIDISM; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; THYROID HORMONES; YOUNG ADULT;

EID: 84255168567     PISSN: 21158789     EISSN: 21157863     Source Type: Journal    
DOI: 10.1684/pnv.2011.0300     Document Type: Article

References (60)

1. Dugbartey AT. Neurocognitive aspects of hypothyroidism. Arch Intern Med 1998 ; 158: 1413-8. (Pubitemid 28317756)
2. Sellal F, Becker H. Potentially reversible dementia. Presse Med 2007 ; 36: 289-98. (Pubitemid 46546553)
3. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol [Oxf] 1995 ; 43: 55-68.
4. Laurberg P, Andersen S, Bulow Pedersen I, Carle A. Hypothyroidism in the elderly: pathophysiology, diagnosis and treatment. Drugs Aging 2005 ; 22: 23-38. (Pubitemid 40188903)
5. Morganti S, Ceda GP, Saccani M, Milli B, Ugolotti D, Prampolini R, et al. Thyroid disease in the elderly: sex-related differences in clinical expression. J Endocrinol Invest 2005 ; 28: 101-4.
6. Ruel J, Faure R, Dussault JH. Regional distribution of nuclear T3 receptors in rat brain and evidence for preferential localization in neurons. J Endocrinol Invest 1985 ; 8: 343-8. (Pubitemid 16191898)
7. Davis JD, Tremont G. Neuropsychiatric aspects of hypothyroidism and treatment reversibility. Minerva Endocrinol 2007 ; 32: 49-65.
8. Alvarez-Dolado M, Iglesias T, Rodriguez-Pena A, Bernal J, Munoz A. Expression of neurotrophins and the trk family of neurotrophin receptors in normal and hypothyroid rat brain. Brain Res Mol Brain Res 1994 ; 27: 249-57. (Pubitemid 24379207)
9. Calza L, Giardino L, Aloe L. NGF content and expression in the rat pituitary gland and regulation by thyroid hormone. Brain Res Mol Brain Res 1997 ; 51: 60-8. (Pubitemid 27504032)
10. Giordano T, Pan JB, Casuto D, Watanabe S, Arneric SP. Thyroid hormone regulation of NGF, NT-3 and BDNF RNA in the adult rat brain. Brain Res Mol Brain Res 1992 ; 16: 239-45. (Pubitemid 23035966)
11. Guadano-Ferraz A, Benavides-Piccione R, Venero C, Lancha C, Vennstrom B, Sandi C, et al. Lack of thyroid hormone receptor alpha1 is associated with selective alterations in behavior and hippocampal circuits. Mol Psychiatry 2003 ; 8: 30-8. (Pubitemid 36188571)
12. Gerges NZ, Alkadhi KA. Hypothyroidism impairs late LTP in CA1 region but not in dentate gyrus of the intact rat hippocampus: MAPK involvement. Hippocampus 2004 ; 14: 40-5. (Pubitemid 38351170)
13. Ambrogini P, Cuppini R, Ferri P, Mancini C, Ciaroni S, Voci A, et al. Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 2005 ; 81: 244-53. (Pubitemid 41397032)
14. Alzoubi KH, Gerges NZ, Alkadhi K. Levothyroxin restores hypothyroidism-induced impairment of LTP of hippocampal CA1: electrophysiological and molecular studies. Exp Neurol 2005 ; 195: 330-41. (Pubitemid 41297786)
15. Rivas M, Naranjo JR. Thyroid hormones, learning and memory. Genes Brain Behav 2007 ; 6 (Suppl. 1): 40-4. (Pubitemid 46744110)
16. Cummings JL. Treatable dementias. Adv Neurol 1983 ; 38: 165-83.
17. Ganguli M, Burmeister LA, Seaberg EC, Belle S, DeKosky ST. Association between dementia and elevated TSH: a community-based study. Biol Psychiatry 1996 ; 40: 714-25. (Pubitemid 26353964)
18. Cardenas-Ibarra L, Solano-Velazquez JA, Salinas-Martinez R, Aspera-Ledezma TD, Sifuentes-Martinez M, et al. Cross-sectional observations of thyroid function in geriatric Mexican outpatients with and without dementia. Arch Gerontol Geriatr 2008 ; 46: 173-80. (Pubitemid 351222675)
19. Ceresini G, Lauretani F, Maggio M, Ceda GP, Morganti S, Usberti E, et al. Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study. J Am Geriatr Soc 2009 ; 57: 89-93.
20. Kalmijn S, Mehta KM, Pols HA, Hofman A, Drexhage HA, Breteler MM. Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clin Endocrinol [Oxf] 2000 ; 53: 733-7. (Pubitemid 32096685)
21. de Jong FJ, den Heijer T, Visser TJ, de Rijke YB, Drexhage HA, Hofman A, et al. Thyroid hormones, dementia, and atrophy of the medial temporal lobe. J Clin Endocrinol Metab 2006 ; 91: 2569-73. (Pubitemid 44024619)
22. Volpato S, Guralnik JM, Fried LP, Remaley AT, Cappola AR, Launer LJ. Serum thyroxine level and cognitive decline in euthyroid older women. Neurology 2002 ; 58: 1055-61. (Pubitemid 34298545)
23. Tan ZS, Beiser A, Vasan RS, Au R, Auerbach S, Kiel DP, et al. Thyroid function and the risk of Alzheimer disease: the Framingham Study. Arch Intern Med 2008 ; 168: 1514-20.
24. Larson EB, Reifler BV, Featherstone HJ, English DR. Dementia in elderly outpatients: a prospective study. Ann Intern Med 1984 ; 100: 417-23. (Pubitemid 14156550)
25. Clarfield AM. The reversible dementias: do they reverse ? Ann Intern Med 1988 ; 109: 476-86.
26. Clarnette RM, Patterson CJ. Hypothyroidism: does treatment cure dementia ? J Geriatr Psychiatry Neurol 1994 ; 7: 23-7. (Pubitemid 24028152)
27. Osterweil D, Syndulko K, Cohen SN, Pettler-Jennings PD, Hershman JM, Cummings JL, et al. Cognitive function in non-demented older adults with hypothyroidism. J Am Geriatr Soc 1992 ; 40: 325-35.
28. Capet C, Jego A, Denis P, Noel D, Clerc I, Cornier AC, et al. Is cognitive change related to hypothyroidism reversible with replacement therapy ? Rev Med Interne 2000 ; 21: 672-8. (Pubitemid 30641199)
29. del Ser Quijano T, Delgado C, Martinez Espinosa S, Vazquez C. Cognitive deficiency in mild hypothyroidism. Neurologia 2000 ; 15: 193-8. (Pubitemid 30337439)
30. Jensovsky J, Ruzicka E, SpackovaN, Hejdukova B. Changes of event related potential and cognitive processes in patients with subclinical hypothyroidism after thyroxine treatment. Endocr Regul 2002 ; 36: 115-22. (Pubitemid 35167969)
31. Jorde R, Waterloo K, Storhaug H, Nyrnes A, Sundsfjord J, Jenssen TG. Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment. J Clin Endocrinol Metab 2006 ; 91: 145-53. (Pubitemid 43069130)
32. Miller KJ, Parsons TD, Whybrow PC, van Herle K, Rasgon N, van Herle A, et al. Memory improvement with treatment of hypothyroidism. Int J Neurosci 2006 ; 116: 895-906. (Pubitemid 44154975)
33. Correia N, Mullally S, Cooke G, Tun TK, Phelan N, Feeney J, et al. Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism. J Clin Endocrinol Metab 2009 ; 94: 3789-97.
34. Wekking EM, Appelhof BC, Fliers E, Schene AH, Huyser J, Tijssen JG, et al. Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. Eur J Endocrinol 2005 ; 153: 747-53. (Pubitemid 43020224)
35. Haggerty JJ Jr., Stern RA, Mason GA, Beckwith J, Morey CE, Prange AJ Jr. Subclinical hypothyroidism: a modifiable risk factor for depression ? Am J Psychiatry 1993 ; 150: 508-10. (Pubitemid 23072484)
36. Manciet G, Dartigues JF, Decamps A, Barberger-Gateau P, Letenneur L, Latapie MJ, et al. The PAQUID survey and correlates of subclinical hypothyroidism in elderly community residents in the southwest of France. Age Ageing 1995 ; 24: 235-41.
37. Chueire VB, Romaldini JH, Ward LS. Subclinical hypothyroidism increases the risk for depression in the elderly. Arch Gerontol Geriatr 2007 ; 44: 21-8. (Pubitemid 44755445)
38. Engum A, Bjoro T, Mykletun A, Dahl AA. An association between depression, anxiety and thyroid function-a clinical fact or an artefact ? Acta Psychiatr Scand 2002 ; 106: 27-34. (Pubitemid 34828145)
39. van Boxtel MP, Menheere PP, Bekers O, Hogervorst E, Jolles J. Thyroid function, depressed mood, and cognitive performance in older individuals: the Maastricht Aging Study. Psychoneuroendocrinology 2004 ; 29: 891-8. (Pubitemid 38716114)
40. Lass P, Slawek J, Derejko M, Rubello D. Neurological and psychiatric disorders in thyroid dysfunctions. The role of nuclear medicine: SPECT and PET imaging. Minerva Endocrinol 2008 ; 33: 75-84.
41. Constant EL, de Volder AG, Ivanoiu A, Bol A, Labar D, Seghers A, et al. Cerebral blood flow and glucose metabolism in hypothyroidism: a positron emission tomography study. J Clin Endocrinol Metab 2001 ; 86: 3864-70. (Pubitemid 32755990)
42. Zhu DF, Wang ZX, Zhang DR, Pan ZL, He S, Hu XP, et al. fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism. Brain 2006 ; 129: 2923-30. (Pubitemid 44684513)
43. Bauer M, Silverman DH, Schlagenhauf F, London ED, Geist CL, van Herle K, et al. Brain glucose metabolism in hypothyroidism: a positron emission tomography study before and after thyroid hormone replacement therapy. J Clin Endocrinol Metab 2009 ; 94: 2922-9.
44. Nagamachi S, Jinnouchi S, Nishii R, Ishida Y, Fujita S, Futami S, et al. Cerebral blood flow abnormalities induced by transient hypothyroidism after thyroidectomy-analysis by tc-99m-HMPAO and SPM96. Ann Nucl Med 2004 ; 18: 469-77. (Pubitemid 39410245)
45. Krausz Y, Freedman N, Lester H, Newman JP, Barkai G, Bocher M, et al. Regional cerebral blood flow in patients with mild hypothyroidism. J Nucl Med 2004 ; 45: 1712-5. (Pubitemid 47618480)
46. Burmeister LA, Ganguli M, Dodge HH, Toczek T, DeKosky ST, Nebes RD. Hypothyroidism and cognition: preliminary evidence for a specific defect in memory. Thyroid 2001 ; 11: 1177-85. (Pubitemid 34041899)
47. Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frolich M, Westendorp RG. Thyroid status, disability and cognitive function, and survival in old age. JAMA 2004 ; 292: 2591-9. (Pubitemid 39577515)
48. Cook S, Nebes R, Halligan E, Burmeister L, Saxton J, Ganguli M, et al. Memory impairment in elderly individuals with a mildy elevated serum TSH: the role of processing ressources, depression and cerebrovascular dosease. Aging Neuropsychol Cogn 2002 ; 9: 175-183. (Pubitemid 35397521)
49. Roberts LM, Pattison H, Roalfe A, Franklyn J, Wilson S, Hobbs FD, et al. Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction ? Ann Intern Med 2006 ; 145: 573-81. (Pubitemid 46780936)
50. St John JA, Henderson VW, Gatto NM, McCleary CA, Spencer CA, Hodis HN, et al. Mildly elevated TSH and cognition in middle-aged and older adults. Thyroid 2009 ; 19: 111-7.
51. Park YJ, Lee EJ, Lee YJ, Choi SH, Park JH, Lee SB, et al. Subclinical hypothyroidism [SCH] is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life [QoL] in elderly subjects. Arch Gerontol Geriatr 2010 ; 50: e68-73.
52. Wahlin A, Wahlin TB, Small BJ, Backman L. Influences of thyroid stimulating hormone on cognitive functioning in very old age. J Gerontol B Psychol Sci Soc Sci 1998 ; 53: P234-9. (Pubitemid 28340919)
53. Jaeschke R, Guyatt G, Gerstein H, Patterson C, Molloy W, Cook D, et al. Does treatment with L-thyroxine influence health status in middleaged and older adults with subclinical hypothyroidism ? J Gen Intern Med 1996 ; 11: 744-9. (Pubitemid 27009653)
54. Arinzon Z, Zuta A, Peisakh A, Feldman J, Berner Y. Evaluation response and effectiveness of thyroid hormone replacement treatment on lipid profile and function in elderly patients with subclinical hypothyroidism. Arch Gerontol Geriatr 2007 ; 44: 13-9. (Pubitemid 44781117)
55. Nystrom E, Caidahl K, Fager G,Wikkelso C, Lundberg PA, Lindstedt G. A double-blind cross-over 12-month study of L-thyroxine treatment of women with 'subclinical' hypothyroidism. Clin Endocrinol [Oxf] 1988 ; 29: 63-75.
56. Monzani F, Del Guerra P, Caraccio N, Pruneti CA, Pucci E, Luisi M, et al. Subclinical hypothyroidism: neurobehavioral features and beneficial effect of L-thyroxine treatment. Clin Investig 1993 ; 71: 367-71. (Pubitemid 23142835)
57. Baldini IM, Vita A, Mauri MC, Amodei V, Carrisi M, Bravin S, et al. Psychopathological and cognitive features in subclinical hypothyroidism. Prog Neuropsychopharmacol Biol Psychiatry 1997 ; 21: 925-35. (Pubitemid 27410385)
58. Bono G, Fancellu R, Blandini F, Santoro G, Mauri M. Cognitive and affective status in mild hypothyroidism and interactions with L-thyroxine treatment. Acta Neurol Scand 2004 ; 110: 59-66. (Pubitemid 38850557)
59. Samuels MH, Schuff KG, Carlson NE, Carello P, Janowsky JS. Health status, psychological symptoms, mood, and cognition in Lthyroxine- treated hypothyroid subjects. Thyroid 2007 ; 17: 249-58. (Pubitemid 46557374)
60. Walsh JP, Ward LC, Burke V, Bhagat CI, Shiels L, Henley D, et al. Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being, or quality of life: results of a double-blind, randomized clinical trial. J Clin Endocrinol Metab 2006 ; 91: 2624-30. (Pubitemid 44024628)