Evaluation response and effectiveness of thyroid hormone replacement treatment on lipid profile and function in elderly patients with subclinical hypothyroidism

Archives of Gerontology and Geriatrics

Volumn 44, Issue 1, 2007, Pages 13-19

  Arinzon, Zeev ^a,b,c   Zuta, Aneta ^c   Peisakh, Alexander ^c   Feldman, Jacob ^a,d   Berner, Yitshal ^a,d  

^a MEIR MEDICAL CENTER   (Israel)

^b Frieda Schiff Warburg Geriatric Ctr   (Israel)

^c Leumit Research Institue   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cholesterol in elderly; Subclinical hypo thyroidism; Thyroid hormone replacement; Triglycerides in elderly

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEVOTHYROXINE SODIUM; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL;

AGED; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DEMOGRAPHY; EUTHYROIDISM; FEMALE; FUNCTIONAL STATUS; GENDER; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; LIPOPROTEIN BLOOD LEVEL; MALE; MEAN ARTERIAL PRESSURE; MINI MENTAL STATE EXAMINATION; PREVALENCE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOTHYROIDISM; LIPIDS; MALE; RECOVERY OF FUNCTION; THYROXINE; TREATMENT OUTCOME;

EID: 33751238815     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.archger.2006.01.006     Document Type: Article

References (28)

1. Bauer D.C., Ettinger B., and Browner W.S. Thyroid function and serum lipids in older women: a population-based study. Am. J. Med. 104 (1998) 546-551
2. Canaris G.J., Manowitz N.R., Mayor G., and Ridgway E.C. The Colorado thyroid disease prevalence study. Arch. Intern. Med. 160 (2000) 526-534
3. Caraccio N., Ferrannini E., and Monzani F. Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study. J. Clin. Endocrinol. Metab. 87 (2002) 1533-1538
4. Carlsson C.M., Carnes M., McBride P.E., and Stein J.H. Managing dyslipidemia in older adults. J. Am. Geriatr. Soc. 47 (1999) 1458-1465
5. Chu J.W., and Crapo L.M. The treatment of subclinical hypothyroidism is seldom necessary. J. Clin. Endocrinol. Metab. 86 (2001) 4591-4599
6. Danese M.D., Ladenson P.W., Meinert C.L., and Powe N.R. Effect of thyroxine therapy on serum lipoproteins in patients with thyroid failure: a quantitative review of the literature. J. Clin. Endocrinol. Metab. 85 (2000) 2993-3001
7. Dean J.W., and Fowler P.B. Exaggerated responsiveness to thyrotropin releasing hormone: a risk factor in women with coronary artery disease. Br. Med. J. 290 (1985) 15550-15561 (Clin. Res. Ed.)
8. Diekman T., Lansberg P.J., Kastelein J.J., and Wiersinga W.M. Prevalence and correction of hypothyroidism in large cohort of patients referred for dyslipidemia. Arch. Intern. Med. 155 (1995) 1490-1495
9. Feldman J., Peleg L., and Yaretzky A. Comprehensive geriatric assessment it's clinical, social and economic importance and prospects. Harefuah 135 (1999) 933-935
10. Fiedewald W.T., Levy R.I., and Fredrickson D.S. Estimation of concentration of low density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem. 18 (1972) 499-502
11. Folstein M.F., Folstein S.E., and McHugh P.R. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12 (1975) 189-198
12. Franklyn J.A., Daykin J., Betteridge J., Hughes E.A., Holder R., Jones S.R., and Sheppard M.C. Thyroxine replacement therapy and circulating lipid concentrations. Clin. Endocrinol. (Oxf.) 38 (1993) 453-459
13. Geul K.W., Van Sluisveld I.L., Grobbee D.E., Docter R., De Bruyn A.M., Hooykaas H., Van der Merwe J.P., Van Hemert A.M., Krenning E.P., Hennemann G., and Weber R.F.A. The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle-aged women: associations with serum lipids. Clin. Endocrinol. (Oxf.) 39 (1993) 275-280
14. Helfand M., and Redfern C.C. Clinical guideline, part 2. Screening for thyroid disease: an update. American College of Physicians. Ann. Intern. Med. 129 (1998) 144-158
15. Huber G., Mitrache C., Guglielmetti M., Huber P., and Staub J.J. Predictors of overt hypothyroidism and natural course: a long-term follow-up of study in impending thyroid failure. Proceedings of the 71st Annual Meeting of the American Thyroid Association. Portland, OR (1998) (Abstract No. 109)
16. Kagansky N., Levy S., Brener Y., Rimon E., and Knobler H. Cholesterol lowering in the older population: time for reassessment?. Quart. J. Med. 94 (2001) 457-463
17. Katz S., Ford A.B., Moskowitz R.W., Jackson B.A., and Kaffe M.W. Studies of illness in the aged: the index of ADL, a standardized measure of biological and psychological function. J. Am. Med. Assoc. 185 (1963) 914-919
18. Kong W.M., Sheikh M.H., Lumb P.J., Naoumova R.P., Freedman D.B., Crook M., Dore C.J., and Finer N. A randomized controled trial of thyroxine treatment in mild subclinical thyroidism. Proceedings of the 82nd Annual Meeting of the Endocrine Society. Toronto, Canada (2000) 2466-2597
19. Kung A.W.C., Pang R.W.C., and Janus E.D. Elevated serum lipoprotein(a) in subclinical hypothyroidism. Clin. Endocrinol. (Oxf.) 43 (1995) 445-450
20. Meier C., Roth C.B., and Huber G. Clinical and metabolic effects of thyroxine replacement in patients with mild thyroid failure: results from a double-blind placebo-controlled study. Proceedings of the 82nd Annual Meeting Of The Endocrine Society. Toronto, Canada (2000) 2372-2373
21. McDermott M.T., and Ridgway E.C. Subclinical hypothyroidism is mild thyroid failure and should be treated. J. Clin. Endocrinol. Metab. 86 (2001) 4585-4590
22. Miura S., Iitaka M., Yoshimura H., Kitahama S., Fukasawa N., Kawakami Y., Sakurai S., Urabe M., Sakatsume Y., and Ito K. Disturbed lipid metabolism in patients with subclinical hypothyroidism: effect of l-thyroxine therapy. Intern. Med. 33 (1994) 413-417
23. O'Brien T., Dinneen S.F., O'Brien P.C., and Palumbo P.J. Hyperlipidemia in patients with primary and secondary hypothyroidism. Mayo Clin. Proc. 68 (1993) 860-866
24. Parle J.V., Franklin J.A., Cross K.W., Jones S.R., and Sheppard M.C. Circulating lipids and minor abnormalities of thyroid function. Clin. Endocrinol. (Oxf.) 37 (1992) 411-414
25. Tanis B.C., Westendorp R.G.J., and Smelt A.H.M. Effect of thyroid substitution on hypercholesterolemia in patients with subclinical hypothyroidism: a retrospective analysis of intervention studies. Clin. Endocrinol. 44 (1996) 643-649
26. Tièche M., Lupi G.A., Gutzwiller F., Grob P.J., Studer H., and Burgi H. Borderline low thyroid function and thyroid autoimmunity. Risk factors for coronary heart disease?. Br. Heart J. 46 (1981) 202-206
27. Trotzas T., Krassas G.E., Konstantinidis T., and Bougoulia M. Changes in lipo-protein (a) levels in overt and subclinical hypothyroidism before and during treatment. Thyroid 10 (2000) 803-808
28. Vierhapper H., Nardi A., Grosser P., Raber W., and Gessl A. Low-density lipoprotein cholesterol in subclinical hypothyroidism. Thyroid 10 (2000) 981-984