Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 50, 2011, Pages 20265-20270

  Thomson, Ty M ^a,d   Benjamin, Kirsten R ^b,e   Bush, Alan ^c   Love, Tonya ^b,f   Pincus, David ^b,g   Resnekov, Orna ^b   Yu, Richard C ^b   Gordon, Andrew ^b,h   Colman Lerner, Alejandro ^b,c   Endy, Drew ^a,i   Brent, Roger ^b,j  

^a Massachusetts Institute of Technology   (United States)

^b The Molecular Sciences Institute   (United States)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^d Selventa   (United States)

^e Amyris Biotechnologies   (United States)

^f Healthy and Active before 5   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h Renaissance Technologies   (United States)

ⁱ Stanford University   (United States)

^j USA   (United States)

more..

Author keywords

Genetic algorithmic model optimization; Quantitative immunoblotting; Single cell fluorescence quantification

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHEROMONE; SCAFFOLD PROTEIN;

ARTICLE; CELL CYCLE; COMPUTER MODEL; ENZYME ACTIVATION; FLUORESCENCE; GENETIC ALGORITHM; IMMUNOBLOTTING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; REPORTER GENE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; YEAST;

FLUORESCENCE; IMMUNOBLOTTING; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; PHEROMONES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 84155179185     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004042108     Document Type: Article

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